“…We also provide current knowledge related to key pathways and factors such as VEGF and RhoA/ROCK signaling that control lymphatic endothelial cell junctional integrity.…”
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“…All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00262-0) contains supplementary material, which is available to authorized users.…”
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“…To address the aforementioned issues, we apply DCNNs to improve the quality of rock CT images and reduce exposure times by more than 60%, simultaneously. …”
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“…In the harshest environmental conditions of the Antarctic desert, normally incompatible with active life, microbes are adapted to exploit the cryptoendolithic habitat (i.e., pore spaces of rocks) and represent the predominant life-forms. …”
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“…Our results suggested that obesity could inhibit 11 MI promoters, including NPPB, NPPA, IRS1, SMAD3, MIR155, ADRB1, AVP, MAPK14, MC3R, ROCK1, and COL3A1, which were mainly involved in blood pressure-related pathways. …”
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“…We collected a dataset from 101 rock pools along a freshwater to brackish water transition on islands of the Baltic Sea and investigated the patterns and drivers of community composition and species richness of diatoms, cyanobacteria and non-cyanobacteria bacteria among islands. …”
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“…Changes of failure mechanism with increasing confinement, from extensional-to shear-dominated failure, are widely observed in the rupture of intact specimens at the laboratory scale and in rock masses. In the previous analysis conducted in 2018, both unconfined and triaxial compressive tests were conducted to investigate the strength characteristics of some specimens of a Utah coal, including the spalling limits, the ratio of apparent unconfined compressive strength (AUCS) to unconfined compressive strength (UCS), the damage characteristics, and the post-yield dilatancy. …”
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“…The paper presents the basic problem related with practical application of carbonate rocks in construction: are carbonate aggregates produced from such rocks favorable for building engineering, particularly for road design and construction? …”
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“…Six species of Nostolepis have been reported in China, including one species from the Xitun Formation (Lochkovian, Lower Devonian) of Qujing, eastern Yunnan. Acid preparation of rock samples from the Xitun Formation has yielded abundant acanthodian remains. …”
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“…Our coupled hydro-mechanical simulation and poro-mechanical analysis of basement fault stability suggest that the combined aquifer contraction and basement rock expansion act together to modulate the effective stress regime and anthropogenic seismicity on the basement faults in Delhi region.…”
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“…In the course of our research, aimed at improving sugar beets phosphorus nutrition, we isolated and characterized Streptomyces sp. strains, endemic from sugar beet fields of the Beni-Mellal region, which are able to use natural rock phosphate (RP) and tricalcium phosphate (TCP) as sole phosphate sources. …”
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“…The saline water type characteristics are derived from agricultural activities, while the mixed water types occur from water–rock interaction. Multivariate analysis performance suggests that industrial, agricultural, and weathering activities have contributed to groundwater contamination. …”
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“…Interlayers act as a cap rock or carrier bed on gas distribution. Along with the variation of breakthrough pressure of the interlayer and saturation pressure of the reservoir, the single sand body shows different distribution features of gas and water. …”
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“…Our findings led to the first model of E. ruminantium infection in host cells in vitro, and we highlight potential biomarkers of E. ruminantium infection in endothelial cells (such as ROCK1, TMEM16K, Albumin and PTPN1), which may be important to further combat Heartwater, namely by developing non-antibiotic-based strategies.…”
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“…Rock materials show dramatic dynamic weakening in large‐displacement (m), high‐velocity (∼1 m/s) friction experiments, providing a mechanism for the generation of large, natural earthquakes. …”
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“…Plant resulted in a change of earth surface albedo and the hydrological cycle, as well as increased rock weatherability thereby causing a persistent change in atmospheric CO(2) and O(2). …”
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“…Notably, inhibitors of the p38α and mTOR pathways enhanced resolution of the condensates, and inhibitors of the Rho–ROCK pathway induced INAVA’s competing function by recruiting INAVA to newly assembled intercellular junctions in cells where none existed before.…”
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“…Soluble factors that provide supportive cues, including fibroblast growth factors (FGFs) and neurotrophic factors, as well as chemical inhibitors of Rho-associated kinase (ROCK), epidermal growth factor receptor (EGFR), and transforming growth factor β receptor (TGFβR) have shown increases in important markers including aquaporin 5 (Aqp5); muscle, intestine, and stomach expression 1 (Mist1); and keratin (K5). …”
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“…The natural source mechanism of the groundwater chemical components in Chaoyang District includes rock weathering, dissolution and cation exchange, while the human-made sources are mainly residents and industrial activities. …”
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“…In addition, MKI-2 inhibited MASTL kinase rather than other AGC kinases, such as ROCK1, AKT1, PKACα, and p70S6K. Furthermore, MKI-2 exerted various antitumor activities by inducing mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. …”
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