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7801“…Moreover, we showed the involvement of the cytoskeletal protein profilin2 and its upstream effectors RhoA/ROCK in actin rod assembly in SMA. These findings implicate that the formation of actin rods exerts detrimental effects on motoneuron homeostasis by affecting actin dynamics and disturbing essential cellular pathways.…”
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7802por Vargas-Accarino, Elena, Herrera-Montávez, Carlos, Ramón y Cajal, Santiago, Aasen, Trond“…Inhibition of mTOR or Rho-associated protein kinase (ROCK) significantly increased cell death specifically in the floating and not the adherent cell population. …”
Publicado 2021
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7803por Ashghali-Farahani, Mansoureh, Khachian, Alice, Vakilian, Parya, Mahmoudi, Mokhtar“…Sensitivity and specificity were assessed and analyzed by Rock Chart analysis. Descriptive and analytical statistical tests were used at a significant level of 0.05. …”
Publicado 2021
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7804por Schulze-Makuch, Dirk, Lipus, Daniel, Arens, Felix L., Baqué, Mickael, Bornemann, Till L. V., de Vera, Jean-Pierre, Flury, Markus, Frösler, Jan, Heinz, Jacob, Hwang, Yunha, Kounaves, Samuel P., Mangelsdorf, Kai, Meckenstock, Rainer U., Pannekens, Mark, Probst, Alexander J., Sáenz, Johan S., Schirmack, Janosch, Schloter, Michael, Schmitt-Kopplin, Philippe, Schneider, Beate, Uhl, Jenny, Vestergaard, Gisle, Valenzuela, Bernardita, Zamorano, Pedro, Wagner, Dirk“…Our results show that hypolith colonized rocks are microbial hotspots in the desert environment. …”
Publicado 2021
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7805por He, Yanfeng, Liao, Kaili, Bai, Jinmei, Fu, Lipei, Ma, Qianli, Zhang, Xiang, Ren, Zhangkun, Wang, Weiyang“…Relatively speaking, alkanolamide (CDEA), a nonionic surfactant, has the characteristics of a small adsorption amount on the rock surface, no cloud point, good temperature resistance, and good salt resistance. …”
Publicado 2021
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7806“…Here, our aim was to examine the taxonomic and functional alpha and beta diversities of diatoms in a coastal rock pool system characterized by a naturally high environmental heterogeneity. …”
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7807“…Experimental analyses firstly confirmed that GNA13, GJA1, and ROCK2, a downstream effector of GNA13, were all increased in 5XFAD mice, compared to littermate mice. …”
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7808“…The energy utilization rate decreases continuously, and the overall dispersion of statistical data decreases gradually. In rock fragmentation engineering, the optimum loading condition is low-speed loading regardless of energy utilization efficiency or fracture toughness. …”
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7809por SUN, Shuai, YANO, Shota, NAKANISHI, Momo O, HIROSE, Michiko, NAKABAYASHI, Kazuhiko, HATA, Kenichiro, OGURA, Atsuo, TANAKA, Satoshi“…While the presence of FGF4, heparin, and activin A was not sufficient to support the proliferation of TSCs, the addition of a pan-retinoic acid receptor inverse agonist and a ROCK-inhibitor yielded a proliferation rate comparable to that obtained under the conventional FBS-based conditions. …”
Publicado 2021
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7810“…Rising temperature will cause the changes of pore characteristics and strength property in rock. This research takes the limestone produced in Taihang Mountains as the research object, and performs high-temperature treatment within 25–1000 °C. …”
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7811por Mathur, Ryan, Mahan, Brandon, Spencer, Marissa, Godfrey, Linda, Landman, Neil, Garb, Matthew, Graham Pearson, D., Liu, Sheng-Ao, Oboh-Ikuenobe, Francisca E.“…Here, we present Zn isotope data for sedimentary rock layers of the K-Pg boundary, which display heavier Zn isotope compositions and lower Zn concentrations relative to surrounding sedimentary rocks, the carbonate platform at the impact site, and most carbonaceous chondrites. …”
Publicado 2021
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7812por Yamashita, Futoshi, Fukuyama, Eiichi, Xu, Shiqing, Kawakata, Hironori, Mizoguchi, Kazuo, Takizawa, Shigeru“…Here, we show that foreshock activity can shed light on understanding the earthquake preparation process based on results of meter-scale rock friction experiments. Experiments were conducted under two different fault surface conditions before each run: less heterogeneous fault without pre-existing gouge and more heterogeneous fault with pre-existing gouge. …”
Publicado 2021
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7813por Li, Qifei, Dibus, Michal, Casey, Alicia, Yee, Christina S. K., Vargas, Sara O., Luo, Shiyu, Rosen, Samantha M., Madden, Jill A., Genetti, Casie A., Brabek, Jan, Brownstein, Catherine A., Kazerounian, Shideh, Raby, Benjamin A., Schmitz-Abe, Klaus, Kennedy, John C., Fishman, Martha P., Mullen, Mary P., Taylor, Joan M., Rosel, Daniel, Agrawal, Pankaj B.“…Evidence of smooth muscle hypertrophy on lung biopsy and an increase in RhoA/ROCK signaling in patient cells suggests the potential mechanistic link between ARHGAP42 deficiency and the development of chILD disorder.…”
Publicado 2021
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7814por Huang, Chi-Yue, Wang, Pinxian, Yu, Mengming, You, Chen-Feng, Liu, Char-Shine, Zhao, Xixi, Shao, Lei, Zhong, Guangfa, Yumul, Graciano P“…Radiometric dates of key rock units indicate that a remnant Late Mesozoic ocean of the Huatung Basin is still preserved today east of the South China Sea (SCS). …”
Publicado 2019
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7815“…In the near future, CE-5 will land again on the near-side of the Moon and take lunar rock and soil samples back to Earth, thus completing the three-step plan of CLEP. …”
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7816“…To study the influence of different factors on the cracking effect of the liquid CO(2) phase transition, the mechanics of coal rock crack extension based on liquid CO(2) phase change blast loading were studied. …”
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7817“…A striking observation is that we could reduce this selective advantage by varying the hPSC culture conditions with the addition of ROCK inhibitor (ROCKi). This work is unique in (1) demonstrating a novel gene that confers selective advantage to hPSCs when overexpressed and may help explain a common trisomy dominance, (2) providing a selection model for studying culture conditions that reduce the appearance of genomically altered hPSCs, and (3) aiding in elucidation of a mechanism that may act as a molecular switch during culture adaptation.…”
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7818por De Falco, Natalie, Tal-Berger, Reut, Hjazin, Amgad, Yizhaq, Hezi, Stavi, Ilan, Rachmilevitch, Shimon“…Vegetation surveys were conducted on different hillslopes, either with or without rock covers in order to study the spatial trends of hillslope geodiversity. …”
Publicado 2021
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7819por Nuhu, Habila, Hashim, Suhairul, Aziz Saleh, Muneer, Syazwan Mohd Sanusi, Mohamad, Hussein Alomari, Ahmad, Jamal, Mohamad Hidayat, Abdullah, Rini Asnida, Hassan, Sitti Asmah“…Locations on igneous granite rock geology were characterized by higher soil radon gas activity and higher GRP, making them radon-prone areas according to international standards. …”
Publicado 2021
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7820por Zhao, Rui“…Then, the mechanical and deformation distribution of the feet-reinforcement bolt in the steel frame—foot-reinforcement bolt combined support system is analyzed under different levels of surrounding rock load and different structural parameters of the feet-reinforcement bolt. …”
Publicado 2021
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