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8281por Horváth, Ádám I., Gyimesi, Máté, Várkuti, Boglárka H., Képiró, Miklós, Szegvári, Gábor, Lőrincz, István, Hegyi, György, Kovács, Mihály, Málnási-Csizmadia, András“…To unveil mechanisms of NM2 pharmacological control, we determined how the dynamics of NM2 diffusion is affected by NM2′s allosteric inhibitors, i.e. blebbistatin derivatives, as compared to Y-27632 inhibiting ROCK, NM2′s upstream regulator. We found that NM2 diffusion is markedly faster in central fibers than in peripheral stress fibers. …”
Publicado 2020
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8282por Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, Chih‐Yi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura J., Robbins, Paul D., Huard, Johnny“…Expression of constitutively active RhoA promoted, while the inhibition of RhoA/ROCK reduced cytoskeletal stiffness, Sun2 expression, the innate immune response, and cellular senescence. …”
Publicado 2020
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8283“…The probability of dying from illness or non-traumas (e.g., high-altitude illness, hypothermia), relative to dying from falling or from ‘objective hazards’ (avalanche, rock or ice fall), increased marginally with age. …”
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8284por Nagel, Stefan, Pommerenke, Claudia, MacLeod, Roderick A.F., Meyer, Corinna, Kaufmann, Maren, Drexler, Hans G.“…Genomic profiling revealed copy number gains at the loci of HLX and STAT3 in addition to genes encoding both STAT3 regulators (AURKA, BCL3, JAK3, KPNB1, NAMPT, NFAT5, PIM3, ROCK1, SIX1, TPX2, WWOX) and targets (BATF3, IRF4, miR135b, miR21, RORC). …”
Publicado 2020
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8285“…On the one hand, the patient’s demand for antibiotics without valid prescriptions, and pharmacist’s wish to assist based on their role in the pharmacy, the pressure for profits and on the understanding of the larger forces driving the practices of self-medication with antibiotics - rock. On the other hand, pharmacists are aware of the legal status of antibiotics and the public health consequences of their inappropriate dispensing practices and their professional and ethical responsibility for upholding the law - hard place. …”
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8286por Rizzi, M., Hovikoski, J., Schovsbo, N. H., Therkelsen, J., Olivarius, M., Nytoft, H. P., Nga, L. H., Thuy, N. T. T., Toan, D. M., Bojesen-Koefoed, J., Petersen, H. I., Nielsen, L. H., Abatzis, I., Korte, C., Fyhn, M. B. W.“…Understanding of the processes of petroleum source rock (SR) accumulation in lacustrine rift basins and the behavior of lake systems as long-term carbon sinks is fragmentary. …”
Publicado 2020
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8287por Domińska, Kamila, Kowalska, Karolina, Urbanek, Kinga Anna, Habrowska-Górczyńska, Dominika Ewa, Ochędalski, Tomasz, Piastowska Ciesielska, Agnieszka Wanda“…In the both lines, Ang-(3-7) improved ROCK1 gene expression however, increased VEGF and NOS3 mRNA was only seen in the PC3 or LNCaP cells, respectively. …”
Publicado 2020
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8288por Asouti, Eleni, Baird, Douglas, Kabukcu, Ceren, Swinson, Kate, Martin, Louise, García-Suárez, Aroa, Jenkins, Emma, Rasheed, Kamal“…The new Palegawra chronology alongside our detailed studies of its material culture and faunal and botanical assemblages suggest that the prevailing Epipalaeolithic habitation pattern in the NW Zagros (centred on generalised persistent occupations of small caves and rock-shelters alongside task-oriented ephemeral open-air campsites) remained an enduring characteristic of the Zarzian horizon throughout this period. …”
Publicado 2020
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8289por Carrera-Játiva, Patricio D., Morgan, Eric R., Barrows, Michelle, Jiménez-Uzcátegui, Gustavo, Tituaña, Jorky Roosevelt Armijos“…This review summarizes the gastrointestinal parasites found in zoo birds globally and in seven common free-ranging avian species [mallard (Anas platyrhynchos), Eurasian blackbird (Turdus merula), common starling (Sturnus vulgaris), Eurasian jackdaw (Corvus monedula), house sparrow (Passer domesticus), European robin (Erithacus rubecula), and rock dove (Columba livia)] to identify the overlap and discuss the potential for cross-species transmission. …”
Publicado 2020
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8290por Zhang, Mengkai, Han, Yue, Liu, Jing, Liu, Lefeng, Zheng, Longqing, Chen, Yongxiong, Xia, Rongmu, Yao, Dongbo, Cai, Xuemin, Xu, Xiuqin“…Importantly, we demonstrated that Rbm24 regulated AS of Mef2d, Naca, Rock2 and Lrrfip1 which are essential for myogenic differentiation and muscle regeneration. …”
Publicado 2020
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8291por Falcon-Suarez, Ismael Himar, Livo, Kurt, Callow, Ben, Marin-Moreno, Hector, Prasad, Manika, Best, Angus Ian“…Clogging of fluid transport pathways in rocks from CO(2)-induced salt precipitation reduces injectivity and potentially compromises the reservoir storage integrity through pore fluid pressure build-up. …”
Publicado 2020
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8292por Wegwitz, Florian, Prokakis, Evangelos, Pejkovska, Anastasija, Kosinsky, Robyn Laura, Glatzel, Markus, Pantel, Klaus, Wikman, Harriet, Johnsen, Steven A.“…We demonstrate that RNF40-driven H2B monoubiquitination is essential for transcriptional activation of RHO/ROCK/LIMK pathway components and proper actin-cytoskeleton dynamics through a trans-histone crosstalk with histone 3 lysine 4 trimethylation (H3K4me3). …”
Publicado 2020
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8293“…Upon referral to our department, her archived tissue samples were submitted for next-generation sequencing (Burning Rock Biotech) and immunohistochemistry, which identified the presence of a novel AMBRA1-ALK rearrangement and ALK overexpression, respectively. …”
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8294por Ooi, Mei C., Goulden, Evan F., Trotter, Andrew J., Smith, Gregory G., Bridle, Andrew R.“…Outbreaks of white leg disease (WLD) with distinct signs of pereiopod tissue whitening and death have been observed in cultured larvae (phyllosomas) of ornate spiny lobster Panulirus ornatus, eastern rock lobster Sagmariasus verreauxi, and slipper lobster Thenus australiensis. …”
Publicado 2020
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8295“…Inhibitors of transforming growth factor β receptor I (TGFβRI) and Rho-associated protein kinase (ROCK) were effective in preventing and reversing myofibroblast gene expression. …”
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8296por Santomartino, Rosa, Waajen, Annemiek C., de Wit, Wessel, Nicholson, Natasha, Parmitano, Luca, Loudon, Claire-Marie, Moeller, Ralf, Rettberg, Petra, Fuchs, Felix M., Van Houdt, Rob, Finster, Kai, Coninx, Ilse, Krause, Jutta, Koehler, Andrea, Caplin, Nicol, Zuijderduijn, Lobke, Zolesi, Valfredo, Balsamo, Michele, Mariani, Alessandro, Pellari, Stefano S., Carubia, Fabrizio, Luciani, Giacomo, Leys, Natalie, Doswald-Winkler, Jeannine, Herová, Magdalena, Wadsworth, Jennifer, Everroad, R. Craig, Rattenbacher, Bernd, Demets, René, Cockell, Charles S.“…We performed the ESA BioRock experiment on the International Space Station to study microbe-mineral interactions in microgravity, simulated Mars gravity and simulated Earth gravity, as well as in ground gravity controls, with three bacterial species: Sphingomonas desiccabilis, Bacillus subtilis, and Cupriavidus metallidurans. …”
Publicado 2020
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8297por Townshend, Ryan F., Shao, Yue, Wang, Sicong, Cortez, Chari L., Esfahani, Sajedeh Nasr, Spence, Jason R., O’Shea, K. Sue, Fu, Jianping, Gumucio, Deborah L., Taniguchi, Kenichiro“…Further, using chemical, genetic and biomechanical tools, we show that NPC rosette morphogenesis requires this basal spreading activity and that spreading is tightly regulated by Rho/ROCK signaling. This robust and quantitative NPC rosette platform provides a sensitive system for the further investigation of cellular and molecular mechanisms underlying NPC rosette morphogenesis.…”
Publicado 2020
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8298“…[Image: see text] Black shale deposited in the transitional period from the Late Ordovician to Early Silurian is the most important source rock and shale gas reservoir in the Yangtze region of South China. …”
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8299por Altamirano, Tomás A., de Zwaan, Devin R., Ibarra, José Tomás, Wilson, Scott, Martin, Kathy“…Alpine birds were almost exclusively migratory, inhabiting a restricted elevational range, and breeding in rock cavities. We conclude that elevation and habitat heterogeneity structure avian trait distributions and community composition, with a diverse ecotonal sub-alpine and a distinct alpine community.…”
Publicado 2020
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8300“…Low b-values revealed the degree of variation in rock properties, including large stress and strain, a fractured medium, a high deformation rate, and large faults. …”
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