“…This study was aimed to investigate whether inhibition of RhoA/ROCK signaling pathway contributes to the cardiac protection by low-intensity ExT in SHRs. …”
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“…The engineering geological problems of soft rock are common in large slope engineering and underground engineering surrounding rock. …”
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“…Here, we investigated morphological differences in recently settled southern rock lobster (Jasus edwardsii) recruits, known as pueruli, along a latitudinal and temporal gradient on the east coast of Tasmania, Australia. …”
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“…To elucidate the additive effects of the ROCK inhibitors (ROCK-i), ripasudil (Rip) and Y27632 on bimatoprost acid (BIM-A), a prostaglandin analog (PG), on adipose tissue, two- and three-dimensional (2D or 3D) cultures of 3T3-L1 cells, the most well characterized cells in the field of lipid research, were used. …”
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“…Targeting SCYL3/ROCK2 signaling cascade may be a novel therapeutic strategy for treatment of HCC patients.…”
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“…In contrast to the previous image-captioning research, generating captions from the geological images of rocks is more focused on the background of the images. …”
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“…The validity of calculating the dynamic tensile strength of rock materials based on dynamic Brazilian tests is problematic. …”
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“…In all experiments, sovesudil and PHP-0961, the novel ROCK inhibitors, were equal or superior to the results of the ROCK inhibitor positive control, Y-27632. …”
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“…To solve these problems of poor supporting effect and serious deformation and failure of surrounding rock of mining roadway under deep mining stress, a FLAC-3D numerical calculation model is established with −800 m level no. 2424 upper roadway in the Suncun Coal Mine as the background to compare the stress, deformation, and failure law of surrounding rock of mining roadway under once support and multi-level support with the same support strength. …”
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“…We constructed a balanced database of Indigenous Australian rock art motifs from both isolated and contact Aboriginal groups (those often in contact with other groups). …”
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“…As a geothermal resource with large reserves, high energy storage, clean and pollution-free, dry hot rocks can effectively contribute to the goals. To promote the utilization of dry hot rock, this paper quantitatively studies the factors affecting the development and utilization of dry hot rock, and first summarizes five major influencing factors, namely, resources, environment, market, exploration and development technology, and effective use of technology. …”
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“…This work presents a new finite-difference continuum damage mechanics approach for assessment of threshold stresses based on the mechanical response of a representative volume element of a sandy-cement rock-like material. An original experimental study allows validating the mathematical model. …”
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“…To unravel the permeability variation mechanism of weakly cemented rocks (WCR), the paper conducted triaxial permeability tests on weakly cemented sandstones (WCS) collected from the Jurassic formation in northwest China. …”
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“…The gene and protein expression levels of Ras homolog gene family, member A (Rho A), ras-related C3 botulinum toxin substrate 1 (Rac 1), Rho-associated kinase 1 (ROCK 1), ROCK 2 in the Rho/ROCK pathway were measured by Real-time PCR (RT-PCR), immunohistochemistry and western blot. …”
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“…It shows unique advantages for rock structure interpretation and has important guiding significance for the research of the shear performances of rock–mortar interface under cyclic load in rock mass engineering. …”
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“…The paper concerns the application a high-pressure abrasive waterjet (AWJ) for cutting the most commonly used rock materials such as granite, limestone, basalt and marble. …”
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“…Phosphate rocks (PRs) play a crucial role in ensuring the availability of phosphorous for the world’s food needs. …”
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“…To investigate the failure effects of critical fissures in rock specimens subjected to plane strain compression (PSC), five types of internal fissures in rock specimens were designed and twelve PSC tests were conducted for two lithologies based on the discrete element method (DEM). …”
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“…In terms of mechanism, we unveil that dasabuvir is a Rho-associated protein kinase 1 (ROCK1) inhibitor. Dasabuvir can bind to ROCK1 and suppress its kinase activity, thus downregulating the phosphorylation of ERK1/2 by ROCK1 and the expression of cyclin-dependent kinase 4 (CDK4) and cyclin D1. …”
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“…To study the influence of fissure angle on the rock damage process and energy evolution characteristics, uniaxial cyclic loading and unloading tests were conducted on fractured rock specimens with different prefabricated fissure angles. …”
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