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  1. 1601
    “…As medidas preventivas como cuidados posturais, boa hidratação, maior ingesta de sal, uso de meias e cintas abdominais compressoras, refeições fracionadas, atividade física supervisionada principalmente sentada, deitada ou exercícios na água são etapas importantes no tratamento. 13. …”
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    Disautonomia: Uma Condição Esquecida – Parte 1
  2. 1602
    por Pamphlett, Roger, Rikard-Bell, Anna
    Publicado 2013
    “…The cause of sporadic amyotrophic lateral sclerosis (SALS) remains unknown. We attempted to find out if occupational exposure to toxicants plays a part in the pathogenesis of this disease. …”
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    Different Occupations Associated with Amyotrophic Lateral Sclerosis: Is Diesel Exhaust the Link?
  3. 1603
    “…Most ALS-cases are sporadic (sALS) and patient heterogeneity poses challenges for effective therapies. …”
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    Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients
  4. 1604
    “…Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. …”
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    Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis
  5. 1605
    “…The pathogenesis of sporadic amyotrophic lateral sclerosis (sALS) remains unknown; however, recent research suggests that genetic factors may play an important role. …”
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    The rs2619566, rs10260404, and rs79609816 Polymorphisms Are Associated With Sporadic Amyotrophic Lateral Sclerosis in Individuals of Han Ancestry From Mainland China
  6. 1606
    “…From this cohort, we compared 532 EPIs with sALS to 1064 EPIs without sALS as controls, matching the subjects by GA and birth weight. …”
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    Risk factors and neonatal outcomes of pulmonary air leak syndrome in extremely preterm infants: A nationwide descriptive cohort study
  7. 1607
    “…This phenotype develops with differentiation into motor neurons, the affected cell type in ALS, and does not occur in the parental undifferentiated sALS cells or sALS neural progenitors. Our work demonstrates a developmentally regulated unifying mitochondrial phenotype between patient derived sALS and fALS motor neurons. …”
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    Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated
  8. 1608
    “…Most cases are sporadic (sALS) with unknown causes suggesting that the etiology of sALS may not be limited to the genotype of patients, but may be influenced by exposure to environmental factors. …”
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    Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis
  9. 1609
    “…Both oxidative phosphorylation and glycolysis appear to be upregulated in lymphoblasts from sALS and SOD1-ALS. Our results indicate significant differences in NRF2/ARE pathway between sALS and SOD1-ALS lymphoblasts. …”
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    Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy
  10. 1610
    por Sirikurnpiboon, Siripong
    Publicado 2021
    “…Most reports of SALS for rectal cancer have shown pathologic outcomes comparable to those of conventional laparoscopic surgery (CLS); however, SALS is considered to be superior to CLS in terms of lower levels of discomfort and faster recovery rates. …”
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    Comparison of Survival between Single-Access and Conventional Laparoscopic Surgery in Rectal Cancer
  11. 1611
    “…As PLS and most ALS cases are sporadic (SALS), this limits the availability of cellular models for investigating pathogenic mechanisms and therapeutic targets. …”
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    Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions
  12. 1612
    por Zhang, Fang, Liu, Mei, Li, Qun, Song, Fei-Xue
    Publicado 2019
    “…Sporadic amyotrophic lateral sclerosis (SALS) is a devastating neurodegenerative disorder. …”
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    Exploration of attractor modules for sporadic amyotrophic lateral sclerosis via systemic module inference and attract method
  13. 1613
    “…Synchronous airway lesions (SALs) may influence the severity and course of the disease. …”
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    Characteristics of Patients with Laryngomalacia: A Tertiary Referral Center Experience of 106 Cases
  14. 1614
    “…Our recent study discovered that the single-nucleotide polymorphisms (SNPs) of rs2619566, rs79609816 and rs10260404 are associated with sporadic ALS (sALS). Thus, this study aims to investigate the hypothalamic functional reorganization and its association with the above polymorphisms risk alleles in sALS patients of Chinese Han ancestry. …”
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    Effect of the Minor C Allele of CNTN4 rs2619566 on Medial Hypothalamic Connectivity in Early-Stage Patients of Chinese Han Ancestry with Sporadic Amyotrophic Lateral Sclerosis
  15. 1615
    “…We investigated the expression of nucleoporins that constitute the nuclear pore complex (NPC) in spinal motor neurons that exhibit sALS in relation to TDP-43 pathology, which is a reliable neuropathological hallmark of sALS. …”
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    Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein
  16. 1616
    “…Objectives: This study compared neurofilament light chain (NFL) levels in the cerebrospinal fluid (CSF) of patients with sporadic amyotrophic lateral sclerosis (sALS) with levels in patients with other neurological diseases and healthy controls and assessed correlations between NFL levels and clinical indicators of sALS. …”
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    CSF Neurofilament Light Chain Elevation Predicts ALS Severity and Progression
  17. 1617
    “…METHODS: In this study, 143 sporadic ALS (sALS) patients (83 men, 60 women) and 210 age- and sex-matched healthy subjects were enrolled. …”
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    Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men
  18. 1618
    “…This work aims to investigate mitophagy in PBMCs of sporadic (sALS) patients and how this pathway can be tuned by using small molecules. …”
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    Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients
  19. 1619
    “…CONCLUSIONS: In sALS, neurons with higher expression levels of Pin1 levels had more TDP-43 inclusions. …”
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    Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis
  20. 1620
    “…Previous research has identified CCNF mutations in familial (FALS) and sporadic amyotrophic lateral sclerosis (SALS), as well as in frontotemporal dementia (FTD). …”
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    Screening for CCNF Mutations in a Chinese Amyotrophic Lateral Sclerosis Cohort
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