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1661por Kim, Joonghee, Kim, Yu Jin, Han, Sangsoo, Choi, Han Joo, Moon, Hyungjun, Kim, Giwoon“…RESULTS: Among 4324 patients, SALS was applied to 2351 (54.4%) and epinephrine was administered in 1644 (38.0%). …”
Publicado 2020
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1662por Zhang, Kang, Liu, Qing, Liu, Keqiang, Shen, Dongchao, Tai, Hongfei, Shu, Shi, Ding, Qingyun, Fu, Hanhui, Liu, Shuangwu, Wang, Zhili, Li, Xiaoguang, Liu, Mingsheng, Zhang, Xue, Cui, Liying“…The rest missense mutations including p.D40G, p.V128M, p.S229R, p.R302C and p.G491R were found in 6 unrelated patients with SALS. CONCLUSIONS: The ANXA11 gene is one of the most frequently mutated genes in Chinese patients with SALS. …”
Publicado 2018
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1663por Theunissen, Frances, Anderton, Ryan S., Mastaglia, Frank L., Flynn, Loren L., Winter, Samantha J., James, Ian, Bedlack, Richard, Hodgetts, Stuart, Fletcher, Sue, Wilton, Steve D., Laing, Nigel G., MacShane, Mandi, Needham, Merrilee, Saunders, Ann, Mackay-Sim, Alan, Melamed, Ze’ev, Ravits, John, Cleveland, Don W., Akkari, P. Anthony“…This study identified a polymorphism in the Stathmin-2 gene and investigated its association with sporadic ALS (sALS) disease risk, age-of onset and survival duration. …”
Publicado 2021
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1664por Wang, Jianwei, Zhang, Ya, Chen, Xiaole, Feng, Yu, Ren, Xiaoyong, Yang, Minjuan, Ding, Ting“…Simulation results show that particles with different diameters have similar release maps for targeted delivery to SALS. Point-source aerosol release (PSAR) method can significantly enhance the DE into the SALS. …”
Publicado 2022
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1665“…BACKGROUND: Epigenetics, and especially DNA methylation, contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). This study aimed to investigate the role of DNA methylation in SALS using whole blood of SALS patients. …”
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1666por Tokuda, Eiichi, Takei, Yo-ichi, Ohara, Shinji, Fujiwara, Noriko, Hozumi, Isao, Furukawa, Yoshiaki“…RESULTS: We found that wild-type SOD1 was misfolded in CSF from all sALS cases examined in this study. The misfolded SOD1 was also detected in CSF from a subset of Parkinson’s disease and progressive supranuclear palsy, albeit with smaller amounts than those in sALS. …”
Publicado 2019
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1667por Prudencio, Mercedes, Belzil, Veronique V., Batra, Ranjan, Ross, Christian A., Gendron, Tania F., Pregent, Luc J., Murray, Melissa E., Overstreet, Karen K., Piazza-Johnston, Amelia E., Desaro, Pamela, Bieniek, Kevin F., DeTure, Michael, Lee, Wing C., Biendarra, Sherri M., Davis, Mary D., Baker, Matthew C., Perkerson, Ralph B., van Blitterswijk, Marka, Stetler, Caroline T., Rademakers, Rosa, Link, Christopher D., Dickson, Dennis W., Boylan, Kevin B., Li, Hu, Petrucelli, Leonard“…ATXN2 and FUS), and cases of sporadic ALS (sALS; 2,229 AS, 716 APA). Furthermore, hnRNPH and other RNA-binding proteins are predicted as potential regulators of cassette exon AS events for both c9ALS and sALS. …”
Publicado 2015
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1668por Canosa, Antonio, Calvo, Andrea, Moglia, Cristina, Vasta, Rosario, Palumbo, Francesca, Solero, Luca, Di Pede, Francesca, Cabras, Sara, Arena, Vincenzo, Zocco, Grazia, Casale, Federico, Brunetti, Maura, Sbaiz, Luca, Gallone, Salvatore, Grassano, Maurizio, Manera, Umberto, Pagani, Marco, Chiò, Adriano“…We evaluated brain metabolic changes characterizing SOD1-ALS as compared to sporadic ALS (sALS), employing (18)fluorodeoxyglucose-positron-emission tomography ((18)F-FDG-PET). …”
Publicado 2022
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1669por Campos-Melo, Danae, Droppelmann, Cristian A, He, Zhongping, Volkening, Kathryn, Strong, Michael J“…RESULTS: Using TaqMan arrays we analyzed 664 miRNAs and found that a large number of miRNAs are differentially expressed in ventral lumbar SC in sALS compared to controls. We observed that the majority of dysregulated miRNAs are down-regulated in sALS SC tissues. …”
Publicado 2013
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1670“…We analyzed mutations in the UBQLN2 gene in a Chinese cohort of 515 patients with sporadic ALS (sALS). A novel missense mutation (p.M392V) was detected in one sALS patient. …”
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1671por Picher-Martel, Vincent, Boutej, Hejer, Vézina, Alexandre, Cordeau, Pierre, Kaneb, Hannah, Julien, Jean-Pierre, Genge, Angela, Dupré, Nicolas, Kriz, Jasna“…Here, we measured 62 different immune/metabolic mediators in plasma of sporadic ALS (sALS) patients. We show that, at the protein level, the majority of immune mediators including a metabolic sensor, leptin, were significantly decreased in the plasma of sALS patients and in two animal models of the disease. …”
Publicado 2023
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1672por Takahashi, Yuji, Uchino, Akiko, Shioya, Ayako, Sano, Terunori, Matsumoto, Chihiro, Numata‐Uematsu, Yurika, Nagano, Seiichi, Araki, Toshiyuki, Murayama, Shigeo, Saito, Yuko“…We used immunohistochemistry to study ErbB4 in the spinal cord of patients with sporadic ALS (SALS) to test the hypothesis that ErbB4 may be involved in the pathogenesis of SALS. …”
Publicado 2019
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1673por Zhang, Fan, Zeng, Dan, Zhang, Cong-Shun, Lu, Jia-Ling, Chen, Teng-Jun, Xie, Jun-Ping, Zhou, Yong-Li“…More than 44% of detected RLH-SALs harboured multiple QTLs/genes associated with ShB resistance, while the other RLH-SALs were putative novel ShB resistance loci. …”
Publicado 2019
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1674por Morello, Giovanna, La Cognata, Valentina, Guarnaccia, Maria, La Bella, Vincenzo, Conforti, Francesca Luisa, Cavallaro, Sebastiano“…A support vector machine classifier based on this 277-gene signature was developed to discriminate patients with sALS from controls, showing significant predictive power in both the discovery dataset and in six independent publicly available gene expression datasets obtained from different sALS tissue/cell samples. …”
Publicado 2023
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1675por Yang, Meimei, Liu, Min, Sánchez, Yajaira Feller, Avazzadeh, Sahar, Quinlan, Leo R., Liu, Gang, Lu, Yin, Yang, Guangming, O'Brien, Timothy, Henshall, David C., Hardiman, Orla, Shen, Sanbing“…Sporadic amyotrophic lateral sclerosis (sALS) is the majority of ALS, and the lack of appropriate disease models has hindered its research. …”
Publicado 2023
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1676por Sangare, Modibo, Dicko, Ilo, Guinto, Cheick Oumar, Sissoko, Adama, Dembele, Kekouta, Coulibaly, Youlouza, Coulibaly, Siaka Y., Landoure, Guida, Diallo, Abdallah, Dolo, Mamadou, Dolo, Housseini, Maiga, Boubacar, Traore, Moussa, Karembe, Mamadou, Traore, Kadiatou, Toure, Amadou, Sylla, Mariam, Togora, Arouna, Coulibaly, Souleymane, Traore, Sékou Fantamady, Hendrickson, Brant, Bricceno, Katherine, Schindler, Alice B., Kokkinis, Angela, Meilleur, Katherine G., Sangho, Hammadoun Ali, Diakite, Brehima, Kassogue, Yaya, Coulibaly, Yaya Ibrahim, Burnett, Barrington, Maiga, Youssoufa, Doumbia, Seydou, Fischbeck, Kenneth H.“…High or low SMN1 copy number and the absence of SMN2 have been reported as risk factors for the development or severity of SALS. OBJECTIVE: To investigate the role of SMN gene copy number in the onset and severity of SALS in Malians. …”
Publicado 2016
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1677por Daneshafrooz, Narges, Joghataei, Mohammad Taghi, Mehdizadeh, Mehdi, Alavi, Afagh, Barati, Mahmood, Panahi, Bahman, Teimourian, Shahram, Zamani, Babak“…Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that in most cases occurs sporadic (sALS). The disease is not curable, and its pathogenesis mechanisms are not well understood yet. …”
Publicado 2022
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1678por Gagliardi, Stella, Zucca, Susanna, Pandini, Cecilia, Diamanti, Luca, Bordoni, Matteo, Sproviero, Daisy, Arigoni, Maddalena, Olivero, Martina, Pansarasa, Orietta, Ceroni, Mauro, Calogero, Raffaele, Cereda, Cristina“…A total of 293 differentially expressed (DE) lncRNAs was found in SALS patients, whereas a limited amount of lncRNAs was deregulated in mutated patients. …”
Publicado 2018
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1679“…Our research group recently described genome-wide characterization of motor cortex samples from sporadic ALS (SALS) patients, revealing the existence of molecular and functional heterogeneity in SALS. …”
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1680por Montibeller, Luigi, Tan, Li Yi, Kim, Joo Kyung, Paul, Praveen, de Belleroche, Jacqueline“…Our results indicate that proteostasis is strongly and selectively activated in SALS motor cortex and spinal cord where subsets of these genes are associated with specific cell type. …”
Publicado 2020
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