“…Considering the role of these genes in triggering processes that allow the parasite to quickly adapt, escape the immune response of the host and start maturation into an adult worm after contact with the portal serum, this work may point to unexplored molecular targets for drug discovery and vaccine development against schistosomiasis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Schistosomiasis chemotherapy is largely based on praziquantel (PZQ). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: To detect acute schistosomiasis, low-intensity infections, or to verify the success of treatment with praziquantel, highly sensitive test methods are required. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Schistosomiasis remains a major public health concern in sub-Saharan Africa. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: In Ethiopia, schistosomiasis is caused by Schistosoma mansoni and S. haematobium with the former being widespread and more than 4 million people are estimated to be infected by S. mansoni annually with 35 million at risk of infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Many children experience first infections early in life and this impacts their growth and development; however praziquantel (PZQ), the drug used worldwide for the treatment of schistosomiasis, only has regulatory approval among adults and children over the age of four, although it is frequently used “off label” in endemic settings. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have shown which transcripts oscillate at this temporal scale and this will benefit the development and delivery of treatments against schistosomiasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12915-021-01189-9.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Prevalence of STH was 15.5% for any STH species, 9.47% for Ascaris lumbricoides, 1.78% for Trichuris trichiura, and 7.24% for hookworm. Intestinal schistosomiasis (Schistosoma mansoni) infection prevalence was 0.85% by Kato Katz, 21.6% by POC-CCA trace positive (Tr +), and 13.3% trace negative (Tr-). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This review presents recent developments in AdV-vectored vaccines targeting five major human parasitic diseases: malaria, Chagas disease, schistosomiasis, leishmaniasis, and toxoplasmosis. Many AdV-vectored vaccines have been developed for these diseases, utilizing a wide variety of vectors, antigens, and modes of delivery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] Praziquantel (PZQ) is a chiral class-II drug, and it is used as a racemate for the treatment of schistosomiasis. The knowledge of several cocrystals with dicarboxylic acids has prompted the realization of solid solutions of PZQ with both enantiomers of malic acid and tartaric acid. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sera from individuals seropositive for HIV-1, but without schistosomiasis, that reacted with the vif peptide also recognized a 170-kD S. mansoni protein. …”
Enlace del recurso
Enlace del recurso

“…This study further highlights the importance of malaria and intestinal schistosomiasis as contributors to reduced haemoglobin levels among schoolchildren and helps guide the implementation of integrated school health programmes in areas of differing parasite transmission.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Re-emergence of schistosomiasis in regions of China where control programs have ceased requires development of molecular-genetic tools to track gene flow and assess genetic diversity of Schistosoma populations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Bird schistosomes, besides being responsible for bird schistosomiasis, are known as causative agents of cercarial dermatitis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Some species are causative agents of human schistosomiasis, the second major neglected disease affecting over 230 million people worldwide. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we present the current context of preventive chemotherapy for some NTDs, and discuss the problems faced by programmes as they consider the ‘endgame’, such as difficulties of access to populations in post-conflict settings, limited human and financial resources, and the need to expand access to clean water and improved sanitation for schistosomiasis and soil-transmitted helminthiasis. In the case of onchocerciasis and lymphatic filariasis, ivermectin treatment carries a significant risk owing to serious adverse effects in some patients co-infected with the tropical eye worm Loa loa filariasis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also active against cancer cells, but its precise mechanism of antitumor action is not fully understood. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Schistosomiasis is a parasitic flatworm disease that infects 200 million people worldwide. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso