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  1. 3441
    “…BACKGROUND: Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. …”
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    In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium
  2. 3442
    “…A considerable insight has been gained concerning the potential of MG-132 as a gene expression modulator, and overall the data suggest that the proteasome might be an important molecular target for the design of new drugs against schistosomiasis.…”
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    Effects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni
  3. 3443
    “…BACKGROUND: Schistosomiasis is one of the most common parasitic diseases affecting millions of humans and animals worldwide. …”
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    Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum
  4. 3444
    “…According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws. …”
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    Patent landscape of neglected tropical diseases: an analysis of worldwide patent families
  5. 3445
    “…Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. …”
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    Rapid clearance of Schistosoma mansoni circulating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community – Relevance for monitoring treatment efficacy and re-infection
  6. 3446
    “…BACKGROUND: Community drug distributors or neglected tropical disease (NTD) volunteers have played a crucial role in ensuring the success of mass drug administration (MDA) programs using preventive chemotherapy (PC) for lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and soil transmitted helminths. …”
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    Review of the factors influencing the motivation of community drug distributors towards the control and elimination of neglected tropical diseases (NTDs)
  7. 3447
    “…BACKGROUND: Schistosomiasis remains a parasitic infection of public health importance especially in Africa south of the Sahara including Cameroon. …”
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    Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon
  8. 3448
    “…BACKGROUND: Schistosomiasis caused by Schistosoma japonicum is among the most serious endemic zoonoses in China. …”
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    Influence of Schistosoma japonicum programmed cell death protein 10 on the growth and development of schistosomula
  9. 3449
    “…BACKGROUND: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. …”
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    Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review
  10. 3450
    “…BACKGROUND: Schistosomiasis is a neglected tropical disease burdening millions of people. …”
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    Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome
  11. 3451
    “…BACKGROUND: Schistosomes are blood dwelling parasitic worms that cause the debilitating disease schistosomiasis. Here we examined the influence of the parasites on their external environment by monitoring the impact of adult Schistosoma mansoni worms on the murine plasma proteome in vitro and, in particular, on how the worms affect the blood coagulation protein high molecular weight kininogen (HK). …”
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    The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin
  12. 3452
    “…Intestinal schistosomiasis, caused by the parasitic trematode Schistosoma mansoni, is a chronic disease and the prolonged and continuous exposure to S. mansoni antigens results in a deviation of the host's immune response. …”
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    Systemic Cytokine and Chemokine Profiles in Individuals With Schistosoma mansoni Infection and Low Parasite Burden
  13. 3453
    “…BACKGROUND: NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism. …”
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    NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB
  14. 3454
    “…Our data show that the Smp38 MAPK signaling pathway is a critical route for parasite development and may present attractive therapeutic targets for the treatment and control of schistosomiasis.…”
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    Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress
  15. 3455
    “…S. mansoni infection may contribute to impaired vaccine responses in endemic populations; effective schistosomiasis control may be beneficial for vaccine efficacy. …”
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    Effect of Schistosoma mansoni infection and its treatment on antibody responses to measles catch-up immunisation in pre-school children: A randomised trial
  16. 3456
    “…This study concerns with infection of B. glabrata snails from different Brazilian localities with S. mansoni in allopatric and sympatric associations that will partially help in understanding the natural epidemiology of schistosomiasis within natural snail populations in watercourses. …”
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    Compatibility Polymorphism Based on Long-Term Host-Parasite Relationships: Cross Talking Between Biomphalaria glabrata and the Trematode Schistosoma mansoni From Endemic Areas in Brazil
  17. 3457
    “…BACKGROUND: Schistosomiasis is a debilitating neglected tropical disease that affects approximately 190 million people around the world. …”
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    In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum
  18. 3458
    “…Metronidazole has side effects and potential drug resistance is a concern. Schistosomiasis, a chronic and painful infection, is caused by various species of the Schistosoma flatworm. …”
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    Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
  19. 3459
    “…BACKGROUND: Schistosomiasis is a neglected tropical disease caused by Schistosoma parasites. …”
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    Mapping Schistosoma mansoni endemicity in Rwanda: a critical assessment of geographical disparities arising from circulating cathodic antigen versus Kato-Katz diagnostics
  20. 3460
    “…BACKGROUND: Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. …”
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    The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
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