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  1. 2021
    “…Furthermore, NUFIP1 knockdown enhanced the expression of senescence-associated-β-galactosidase (SA-β-gal), the SAHF markers HP1γ and trimethylation (H3k9me3), and the senescence-related protein HMGA2, as well as both p53 and its downstream p21 protein expression. …”
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    Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells
  2. 2022
    “…Cellular senescence acts as a potent tumor-suppression mechanism in mammals; however, it also promotes tumor progression in a non-cell-autonomous manner. …”
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    Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production
  3. 2023
    Publicado 2021
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    Erratum: Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis
  4. 2024
    “…We examined mTOR signaling, tumor cell growth, colony formation, apoptosis, senescence, oxidative stress, p21 accumulation and endoplasmic reticulum (ER) stress levels in cells treated with MHY1485 and radiation, either alone or together. …”
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    MHY1485 enhances X-irradiation-induced apoptosis and senescence in tumor cells
  5. 2025
    “…Senescence of myogenic progenitors impedes skeletal muscle regeneration. …”
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    Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo
  6. 2026
    “…Stem cell senescence contributes to stem cell exhaustion and drives various aging‐associated disorders. …”
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    Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation
  7. 2027
    “…Senescent cells are found to accumulate in aged individuals, as well as in cancer patients that receive chemotherapeutic treatment. …”
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    The Contribution of Physiological and Accelerated Aging to Cancer Progression Through Senescence-Induced Inflammation
  8. 2028
    “…The dormancy state is reversible and not associated with a senescence phenotype. This will aid future research on breast cancer dormancy.…”
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    Breast cancer dormancy is associated with a 4NG1 state and not senescence
  9. 2029
    “…However, it is becoming clear that senescence can also be instigated by cellular stress, so-called stress-induced premature senescence (SIPS). …”
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    Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
  10. 2030
    “…Leaf senescence is the terminal stage of leaf development. …”
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    Arabidopsis FHY3 and FAR1 Function in Age Gating of Leaf Senescence
  11. 2031
    “…Low-dose oridonin induced GC cell cycle arrest at G0/G1 and cell senescence by suppressing the c-Myc-AP4 pathway and enhancing p53-p21 signaling. …”
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    Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells
  12. 2032
    “…When cells approached natural replicative senescence, interphase senescent cells displayed genome instability, whereas near-senescent cells that underwent mitosis despite the presence of uncapped telomeres did not. …”
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    Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
  13. 2033
    “…Tubular cell senescence is a common biologic process and contributes to the progression of chronic kidney disease (CKD); however, the molecular mechanisms regulating tubular cell senescence are poorly understood. …”
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    Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
  14. 2034
    “…The aging of the immune system causes the T cells to express several senescence markers such as CD57 and KLRG1, which produce pro-inflammatory cytokine interferon γ (IFN-γ). …”
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    Association between senescence of T cells and disease activity in patients with systemic lupus erythematosus
  15. 2035
    “…Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging therapy. …”
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    Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides
  16. 2036
    “…Cellular senescence plays a crucial role in tumorigenesis, development and immune modulation in cancers. …”
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    Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Lung Adenocarcinoma
  17. 2037
    “…The dysfunction of adipose tissue with aging and the accumulation of senescent cells has been implicated in the pathophysiology of chronic diseases. …”
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    Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence
  18. 2038
    “…BACKGROUND: Leaf senescence is a highly complex and meticulous regulatory process, and the disruption of any factor involved in leaf senescence might lead to premature or delayed leaf senescence and thus result in reduced or increased crop yields. …”
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    Hexokinase gene OsHXK1 positively regulates leaf senescence in rice
  19. 2039
    “…Most of the senescence-related genes were found to be differentially regulated, perhaps for the fine-tuning of various responses in the senescing R. cantleyi flower. …”
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    Transcriptome analysis of Rafflesia cantleyi flower stages reveals insights into the regulation of senescence
  20. 2040
    “…This indicates that senescence in soybean is linked to the accumulation of coumestrol. …”
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    A Potential Role of Coumestrol in Soybean Leaf Senescence and Its Interaction With Phytohormones
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