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2041por Hu, Kangdi, Peng, Xiangjun, Yao, Gaifang, Zhou, Zhilin, Yang, Feng, Li, Wanjie, Zhao, Yuqi, Li, Yanhong, Han, Zhuo, Chen, Xiaoyan, Zhang, Hua“…Moreover, LCD1 overexpression was found to delay dark-induced senescence in detached tomato leaves, and the lcd1 mutant showed accelerated senescence. …”
Publicado 2021
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2042“…While the function of H19 in primary somatic cells has not been defined, a reduction in the abundance of H19 has been reported during senescence in endothelial cells. Given the critical importance of H19 in cell fate decisions, it is likely that understanding the precise function of H19 in somatic cells in general and why reduced levels occur with cellular senescence will provide novel insights into both somatic cell maintenance and the senescence program. …”
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2043por Quimby, Jessica, Erickson, Andrea, Mcleland, Shannon, Cianciolo, Rachel, Maranon, David, Lunn, Katharine, Elliott, Jonathan, Lawson, Jack, Hess, Ann, Paschall, Rene, Bailey, Susan“…Senescence and nitrosative stress were evaluated utilizing p16 and iNOS immunohistochemistry, respectively. …”
Publicado 2021
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2044por Liao, Chieh Ming, Luo, Tianjiao, von der Ohe, Juliane, de Juan Mora, Blanca, Schmitt, Roland, Hass, Ralf“…Cellular senescence of renal tubular cells is associated with chronic diseases and age-related kidney disorders. …”
Publicado 2021
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2045por Zhao, Yangjing, Liu, Xia, Si, Fusheng, Huang, Lan, Gao, Aiqin, Lin, Wenli, Hoft, Daniel F., Shao, Qixiang, Peng, Guangyong“…Mechanistically, citrate promotes excessive lipid biosynthesis and induces disruption of lipid metabolism in tumor cells, resulting in tumor cell senescence and growth inhibition. Furthermore, ATM‐associated DNA damage response cooperates with MAPK and mTOR signaling pathways to control citrate‐induced tumor cell growth arrest and senescence. …”
Publicado 2021
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2046“…A cascade of molecular and cellular events results in the atherosclerotic plaque formation, evolution, and rupture. Moreover, the senescence of multiple cell types present in the vasculature were reported to contribute to atherosclerotic plaque progression and destabilization. …”
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2047por Zhou, Lulin, Niu, Zubiao, Wang, Yuqi, Zheng, You, Zhu, Yichao, Wang, Chenxi, Gao, Xiaoyan, Gao, Lihua, Zhang, Wen, Zhang, Kaitai, Melino, Gerry, Huang, Hongyan, Wang, Xiaoning, Sun, Qiang“…Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. …”
Publicado 2022
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2048por Sun, Jian, Li, Ying, Yang, Xiao, Dong, Wei, Yang, Jiankun, Hu, Qi, Zhang, Cuntai, Fang, Haoshu, Liu, Anding“…Inhibition of mTORC1 or TFEB overexpression rescues the GDF11‐impaired autophagic flux and cellular senescence. Hepatocyte‐specific deletion of GDF11 does not alter serum GDF11 levels and liver senescence. …”
Publicado 2021
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2049“…Cellular senescence and proliferation are essential for wound healing and tissue remodeling. …”
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2050por Zhu, Feng, Alseekh, Saleh, Koper, Kaan, Tong, Hao, Nikoloski, Zoran, Naake, Thomas, Liu, Haijun, Yan, Jianbing, Brotman, Yariv, Wen, Weiwei, Maeda, Hiroshi, Cheng, Yunjiang, Fernie, Alisdair R“…Dark-induced senescence provokes profound metabolic shifts to recycle nutrients and to guarantee plant survival. …”
Publicado 2021
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2051por Rivellini, Cristina, Porrello, Emanuela, Dina, Giorgia, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Bacigaluppi, Marco, Gullotta, Giorgia Serena, Chaabane, Linda, Leocani, Letizia, Marenna, Silvia, Colombo, Emanuela, Farina, Cinthia, Newcombe, Jia, Nave, Klaus-Armin, Pardi, Ruggero, Quattrini, Angelo, Previtali, Stefano C.“…Interestingly, oligodendrocytes lacking JAB1 expression underwent a senescence-like phenotype that fostered chronic inflammation and oxidative stress. …”
Publicado 2022
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2052por Paffenholz, Stella V., Salvagno, Camilla, Ho, Yu-Jui, Limjoco, Matthew, Baslan, Timour, Tian, Sha, Kulick, Amanda, de Stanchina, Elisa, Wilkinson, John E., Barriga, Francisco M., Zamarin, Dmitriy, Cubillos-Ruiz, Juan R., Leibold, Josef, Lowe, Scott W.“…By leveraging these models, we show that the ability to undergo senescence underlies the clinically observed increase in sensitivity of homologous recombination (HR)–deficient HGSOC tumors to platinum-based chemotherapy. …”
Publicado 2022
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2053por Lee, Yun Haeng, Choi, Doyoung, Jang, Geonhee, Park, Ji Yun, Song, Eun Seon, Lee, Haneur, Kuk, Myeong Uk, Joo, Junghyun, Ahn, Soon Kil, Byun, Youngjoo, Park, Joon Tae“…Senescence is a distinct set of changes in the senescence-associated secretory phenotype (SASP) and leads to aging and age-related diseases. …”
Publicado 2022
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2054por Chen, Yanjia, Liu, Zhuanhua, Chen, Hongyu, Huang, Xingfu, Huang, Xiaoxia, Lei, Yang, Liang, Qing, Wei, Jiayi, Zhang, Qin, Guo, Xiaohua, Huang, Qiaobing“…The AOPP-induced senescence was regulated by the state of autophagy in HUVECs. …”
Publicado 2022
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2055
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2056“…BACKGROUND: In Alzheimer’s disease (AD), the neuroinflammatory response mediated by the activation of senescent microglia is closely related to energy dysmetabolism. …”
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2057Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralizationpor Romaniello, Donatella, Gelfo, Valerio, Pagano, Federica, Ferlizza, Enea, Sgarzi, Michela, Mazzeschi, Martina, Morselli, Alessandra, Miano, Carmen, D’Uva, Gabriele, Lauriola, Mattia“…By establishing senescence and regulating EGFR activity and expression, IL-1 exposure ultimately bestows resistance. …”
Publicado 2022
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2058por Wan, Yiqi, Liu, Zhirui, Wu, Andong, Khan, Abdul Haseeb, Zhu, Ying, Ding, Shuangjin, Li, Xueer, Zhao, Ya, Dai, Ximo, Zhou, Jin, Liu, Jiankun, Li, Yuanyuan, Gong, Xueting, Liu, Man, Tian, Xiao-Li“…Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to diabetic complications. …”
Publicado 2022
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2059por Le, Anh-Nhung, Park, Seong-Soon, Le, Minh-Xuan, Lee, Unn Hwa, Ko, Byung Kyun, Lim, Hye Ryeong, Yu, Ri, Choi, Seong Hee, Lee, Byung Ju, Ham, Soo-Youn, Ha, Chang Man, Park, Jeong Woo“…Endothelial cell senescence is involved in endothelial dysfunction and vascular diseases. …”
Publicado 2022
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2060por Zareen, Shah, Ali, Akhtar, Lim, Chae Jin, Khan, Haris Ali, Park, Junghoon, Xu, Zheng-Yi, Yun, Dae-Jin“…Multiple endogenous and environmental signals regulate the intricate and highly complex processes driving leaf senescence in plants. A number of genes have been identified in a variety of plant species, including Arabidopsis, which influence leaf senescence. …”
Publicado 2022
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