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  1. 2061
    “…Blockage of senescence mitigates the fibrotic lesion caused by legumain deficiency. …”
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    Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis
  2. 2062
    “…Senescence being pharmacologically targetable, they open the avenue for second primary cancer prevention.…”
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    The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion
  3. 2063
    “…Senescence is a major response to cancer chemotherapy and has been linked to unfavorable therapy outcomes. …”
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    The Expression of the Senescence-Associated Biomarker Lamin B1 in Human Breast Cancer
  4. 2064
    “…INTRODUCTION: Evidence suggests that the role of senescence in the development of cancer is context-dependent. …”
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    Prp19 Facilitated p21-Dependent Senescence of Hepatocellular Carcinoma Cells
  5. 2065
    por Ohtani, Naoko
    Publicado 2022
    “…Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage. …”
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    The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
  6. 2066
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    Corrigendum: Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
  7. 2067
    “…Accumulation of senescent chondrocytes is thought to drive inflammatory processes and subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis (OA). …”
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    In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes
  8. 2068
    “…Recent mouse model experiments support an instrumental role for senescent cells in age-related diseases and senescent cells may be causal to certain age-related pathologies. …”
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    Metabolic Alterations in Cellular Senescence: The Role of Citrate in Ageing and Age-Related Disease
  9. 2069
    “…Senescence analysis was performed by β-galactosidase staining after 24 and 48 h. …”
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    Senescence State in Mesenchymal Stem Cells at Low Passages: Implications in Clinical Use
  10. 2070
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    Editorial: Cellular Senescence and Cellular Communications Within Tissue Microenvironments During Aging
  11. 2071
    “…Currently, the exploration of senescent cells' impact on the tumor microenvironment and the evaluation of senescence as possible target in colorectal cancer (CRC) therapy demand reliable detection of cellular senescence in vivo. …”
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    Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal Cancer
  12. 2072
    “…Alkaline stress can severely damage leaf cells and, consequently, cause leaf senescence. To understand the molecular regulatory mechanisms and identify vital senescence-associated genes under alkaline stress, we used high-throughput sequencing to study transcriptional changes in Medicago truncatula, a model plant for forage crops. …”
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    Transcriptome Analysis of Leaf Senescence Regulation Under Alkaline Stress in Medicago truncatula
  13. 2073
    “…Detection and quantification of senescent cells remain difficult due to variable phenotypes and the absence of highly specific and reliable biomarkers. …”
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    Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro
  14. 2074
    “…Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonary disease (COPD) and cardiovascular disease. …”
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    Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD
  15. 2075
    “…Regardless of the organism, there are some features common to aging, namely, the loss of proteostasis and cell senescence. Mammalian cell lines have been used as models to study the aging process, in particular, cell senescence. …”
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    The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence
  16. 2076
    “…The finding provides new insights into the beneficial role of G. lemaneiformis polysaccharide (GP) on retarding senescence process.…”
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    Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence
  17. 2077
    “…Over time, BBBD-associated astrocyte dysfunction results in hippocampal and cortical neural hyperexcitability and cognitive deficits. Second, senescent astrocytes accumulate in the brain with age and exhibit a decreased functional capacity and the secretion of senescent-associated secretory phenotype (SASP) factors, which contribute to neuroinflammation and neurotoxicity. …”
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    Blood–Brain Barrier Dysfunction and Astrocyte Senescence as Reciprocal Drivers of Neuropathology in Aging
  18. 2078
    “…Here, we report that aged aryl hydrocarbon receptor-null mice (AhR−/−) had exacerbated cellular senescence and more liver progenitor cells. Senescence-associated markers β-galactosidase (SA-β-Gal), p16(Ink4a) and p21(Cip1) and genes encoding senescence-associated secretory phenotype (SASP) factors TNF and IL1 were overexpressed in aged AhR−/− livers. …”
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    Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells
  19. 2079
    por Diwan, Bhawna, Sharma, Rohit
    Publicado 2022
    “…The process of cellular senescence is rapidly emerging as a modulator of organismal aging and disease. …”
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    Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review
  20. 2080
    “…Cell senescence is a crucial process in cell fate determination and is involved in an extensive array of aging-associated diseases. …”
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    Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
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