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  1. 2101
    “…Chronic kidney disease (CKD) is an increasingly serious public health problem in the world, but the effective therapeutic approach is quite limited at present. Cellular senescence is characterized by the irreversible cell cycle arrest, senescence-associated secretory phenotype (SASP) and senescent cell anti-apoptotic pathways (SCAPs). …”
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    The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity
  2. 2102
    “…BACKGROUND: Cure and long-term survival for non-small cell lung cancer (NSCLC) remains hard to achieve. Cellular senescence, an emerging hallmark of cancer, is considered as an endogenous tumor suppressor mechanism. …”
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    Prognostic implications of cellular senescence in resected non-small cell lung cancer
  3. 2103
    “…Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, and lack of immune system response contribute to the accumulation of senescent cells and their adverse effects in tissues. …”
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    Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
  4. 2104
    “…In addition, FBXW7 deletion induced the senescence-associated secretory phenotype to trigger secondary senescence. …”
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    FBXW7 inactivation induces cellular senescence via accumulation of p53
  5. 2105
    “…In addition, we found that HCP1 could promote the interaction between Grp94 and lysosomes, which led to an increase in the activity of lysosomes and inhibited the senescence of HDFs. At the same time, we found that HCP1 decreased the concentration of Ca(2+) in mitochondria, inhibiting the senescence of HCP1. …”
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    Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence
  6. 2106
    “…However, mechanisms linking fibroblast senescence with CAF activation remain poorly understood. …”
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    Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway
  7. 2107
    “…Up to date, no study has ever connected E2F2 to vascular endothelial cell senescence. Here, we demonstrate that E2F2 is involved in endothelial cellular senescence. …”
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    Alteration of E2F2 Expression in Governing Endothelial Cell Senescence
  8. 2108
    “…Based on this fact, p16 is considered as a specific biomarker for detecting senescent cells and aging. Other studies have found that p16 is not only a senescence marker, but also a protein with many functions outside of senescence and aging. …”
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    P16INK4A—More Than a Senescence Marker
  9. 2109
    por Zhang, Qiang, Zhou, Dong, Liang, Yu
    Publicado 2022
    “…INTRODUCTION: Injury-related cellular senescence may be involved in heterotopic ossification, and no research has been performed about this before. …”
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    Single-Cell Analyses of Heterotopic Ossification: Characteristics of Injury-Related Senescent Fibroblasts
  10. 2110
    “…Prolonged or excessive stimulation from inhaled toxins may cause oxidative stress and DNA damage that can lead to stress-induced senescence in epithelial cells, which can contribute to several airway diseases. …”
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    Role of Carbon Monoxide in Oxidative Stress-Induced Senescence in Human Bronchial Epithelium
  11. 2111
    “…However, the mechanism by which cellular senescence controls vascular remodeling in PH is not fully understood. …”
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    Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
  12. 2112
    “…The selected endogenous control was then validated for its stability in mice and human bone tissues, and in bone marrow stromal cells (BMSCs) following induction of senescence and senolytic treatment. Finally, the utility of selected endogenous control versus U6 was tested by using each as a normalizer to measure the expression of miR-34a, a miRNA known to increase with age and senescence. …”
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    Identification of a suitable endogenous control miRNA in bone aging and senescence
  13. 2113
    “…Therefore, a better understanding of the molecular mechanism responsible for T cell senescence in the TME and development of novel strategies to prevent effector T cell senescence are urgently needed for cancer immunotherapy. …”
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    Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
  14. 2114
    “…Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogenesis. …”
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    The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence
  15. 2115
    “…Cell senescence is a state of limited cell proliferation during a stress response or as part of a programmed process. …”
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    Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence
  16. 2116
    “…Our evaluations revealed that the number of bone marrow hematopoietic cells (BMHCs) started to decrease significantly after 45 years of age, and the number of senescent BMHCs, as determined by senescence-associated beta-galactosidase staining, gradually increased with age. …”
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    Dynamic biological characteristics of human bone marrow hematopoietic stem cell senescence
  17. 2117
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    Retraction Note: Senescence impairs direct conversion of human somatic cells to neurons
  18. 2118
    “…This study investigated the role of aging-/senescence-induced genes (ASIGs) in contributing to osteosarcoma diagnosis, prognosis, and therapeutic agent prediction. …”
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    Identification and characterization of aging/senescence-induced genes in osteosarcoma and predicting clinical prognosis
  19. 2119
    “…Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells secrete pro-inflammatory and tissue-remodeling factors. …”
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    A BDNF-TrkB autocrine loop enhances senescent cell viability
  20. 2120
    “…While the majority of β cells are destroyed in T1D, some β cells escape this fate and become senescent but whether α cell dysfunction involves a senescence program has not been explored. …”
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    Alpha cell dysfunction in type 1 diabetes is independent of a senescence program
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