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  1. 2121
    “…Further, the sensitivity of primary AECII to senescence after coculture with M2 macrophages was strain dependent and correlated to observations of sensitivity to fibrosis and senescence in vivo. …”
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    Natural variation in macrophage polarization and function impact pneumocyte senescence and susceptibility to fibrosis
  2. 2122
    “…Cancer cells survive chemotherapy and cause lethal relapse by entering a senescent state that facilitates expression of many phagocytosis/macrophage-related genes that engender a novel cannibalism phenotype. …”
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    Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells
  3. 2123
    “…When inhibited the autophagy level with 3-MA, the senescent HEI-OC1 cells were alleviated. The autophagy activity in senescent HEI-OC1 cells also could be reduced by overexpressing PIN1 protein. …”
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    PIN1 protects auditory hair cells from senescence via autophagy
  4. 2124
    “…Cellular and vascular senescence were assessed by measuring the amounts of senescence-associated β-galactosidase and senescence markers, including p21 and p53. …”
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    Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
  5. 2125
    “…Recent studies indicate the critical role of AT2 cell senescence during the onset and progression of RIPF. …”
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    Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
  6. 2126
    “…Obtained results suggest that WRKY53 and CRK5 are antagonistic regulators of chlorophyll synthesis/degradation, senescence, and stomatal conductance.…”
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    The CRK5 and WRKY53 Are Conditional Regulators of Senescence and Stomatal Conductance in Arabidopsis
  7. 2127
    “…Aged blood vessels display an increased number of senescent endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). …”
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    A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF
  8. 2128
    “…Mechanical microenvironment and cellular senescence of trabecular meshwork cells (TMCs) are suspected to play a vital role in primary open-angle glaucoma pathogenesis. …”
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    Cell senescence alters responses of porcine trabecular meshwork cells to shear stress
  9. 2129
    “…Based on our previous transcriptomic studies, NC growth arrest was inferred to be accompanied by cellular senescence. In the current study, NC was proven to display the following markers of senescence: high senescence-associated β-galactosidase activity, lipid deposition, DNA damage, and cell cycle inhibition. …”
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    Novel Role of Mammalian Cell Senescence-Sustenance of Muscle Larvae of Trichinella spp
  10. 2130
    “…In this study, we analyzed the protective effects of calorie restriction (CR) against ischemic AKI in senescence-accelerated OXYS rats. We observed that CR afforded OXYS rats with significant nephroprotection. …”
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    Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats
  11. 2131
    “…Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which senescence influences repair are poorly understood. …”
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    Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis
  12. 2132
    “…Also we identified key genes related to cell senescence characteristics using least absolute shrinkage and selection operator (Lasso) regression and univariate COX regression analysis models. …”
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    Establishment of a cell senescence related prognostic model for predicting prognosis in glioblastoma
  13. 2133
    “…We confirmed senescent brain myeloid cells promote peripheral immune cell chemotaxis in vitro. …”
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    CELL SENESCENCE IS A FEATURE AND MODULATOR OF THE AGED INFLAMMATORY BRAIN CELL LANDSCAPE
  14. 2134
    por Carver, Chase, Schafer, Marissa
    Publicado 2022
    “…Tissue microenvironment, induction mechanism, and duration since senescence onset contribute to senescent cell heterogeneity, making identification challenging. …”
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    SPATIALLY RESOLVED MAPPING OF CELL-SPECIFIC SENESCENT PROFILES IN AGING MOUSE BRAIN
  15. 2135
    por Sung, Mi Jeong, Lee, Ae Sin
    Publicado 2022
    “…The senescence of vascular endothelial cells (EC) leads to vascular dysfunction. …”
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    Chrysanthemum coronarium L. Protects against Premature Senescence in Human Endothelial Cells
  16. 2136
    “…Cellular senescence is conditioned through two interrelated processes, i.e., a reduction in adenosine triphosphate (ATP) and the enhancement of reactive oxygen species (ROS) production levels in mitochondria. …”
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    Therapeutic Stimulation of Glycolytic ATP Production for Treating ROS-Mediated Cellular Senescence
  17. 2137
    “…As a cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter a senescent state of stable cell cycle arrest. Senescent melanocytes can persist for months in mice and years in humans with a risk to escape the senescent state and progress to melanoma. …”
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    Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression
  18. 2138
    “…Background: Hepatocellular carcinoma (HCC) is a prevalent malignancy with a high mortality rate. Cellular senescence, an irreversible state of cell cycle arrest, plays a paradoxical role in cancer progression. …”
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    Characterization of cellular senescence patterns predicts the prognosis and therapeutic response of hepatocellular carcinoma
  19. 2139
    “…Upregulation of p53 suppressed the transcription of VLA-4 in senescent dCLN T cells and consequently inhibited their migration to the leptomeningeal compartment. …”
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    VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
  20. 2140
    “…The technical limitation of senescent-cell scarcity(3) was overcome by combining single-cell transcriptomics and a senescent-cell enrichment sorting protocol. …”
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    Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
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