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  1. 2141
    “…The complex leaf senescence process is governed by various levels of transcriptional and translational regulation. …”
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    A cross-species co-functional gene network underlying leaf senescence
  2. 2142
    “…Modulation of autophagy and targeting senescence pathways are emerging as potential treatment strategies. …”
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    Intra‐articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis
  3. 2143
    “…ABSTRACT: An escape from cellular senescence through the development of unlimited growth potential is one of the hallmarks of cancer, which is thought to be an early event in carcinogenesis. …”
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    Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy
  4. 2144
    por Sun, Yu, Li, Qingfeng, Kirkland, James L
    Publicado 2022
    “…Senescent cells cease to proliferate, while remaining metabolically active and secreting numerous extracellular factors, a feature known as the senescence-associated secretory phenotype. …”
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    Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
  5. 2145
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    Does symmetry preclude the evolution of senescence? A comment on Pen and Flatt 2021
  6. 2146
    “…Here, we show that T cell–specific RIPK1 deficiency in mice leads to the premature senescence of T cells and induces various age-related diseases, resulting in premature death. …”
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    RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
  7. 2147
    “…Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. …”
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    Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma
  8. 2148
    “…Oncogene-induced senescence (OIS) was triggered in a subset of mouse hepatocytes, which under normal conditions, are eliminated by immunosurveillance. …”
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    A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes
  9. 2149
    “…Increasing evidence suggests that multiple lines of antitumor therapy can induce a senescent-like phenotype in cancer cells, which may participate in treatment resistance. …”
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    Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy
  10. 2150
    “…Depletion of Mili and piRNAs in the adult hippocampus impairs aNPC differentiation toward a neural fate, induces senescence, and generates reactive glia. Transcripts modulated upon Mili depletion bear sequences complementary or homologous to piRNAs and include repetitive elements and mRNAs encoding essential proteins for proper neurogenesis. …”
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    Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus
  11. 2151
    “…Highly immunogenic tumors showed lesser senescence burden suggesting immune-mediated elimination of senescent cancer cells, likely targeted as a consequence of their senescence-associated secretory phenotype. …”
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    Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis
  12. 2152
    “…Cellular senescence—the irreversible cell cycle arrest driven by a variety of mechanisms and, more specifically, the senescence-associated secretory phenotype (SASP)—is an important area of research in the context of different age-related diseases, such as cardiovascular disease and cancer. …”
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    Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis
  13. 2153
    “…Recent studies showed that surviving cancer cells with an initially senescent phenotype following chemoradiation could escape senescence over time, giving rise to tumor cells that were more aggressive and resilient. …”
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    P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma
  14. 2154
    “…Interestingly, C-terminal lamin A mutations trigger cellular senescence. Recently, we showed that the C-terminal region of lamin A interacts with casein kinase II (CK2). …”
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    Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence
  15. 2155
    “…More surprisingly, 27 (79.4%) of the 34 homologous genes in Arabidopsis were found to be senescence-associated genes (SAGs), further suggesting a close relationship between human diseases and cellular senescence. …”
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    Orthologs of Human-Disease-Associated Genes in Plants Are Involved in Regulating Leaf Senescence
  16. 2156
    “…This study aims to investigate the favorable action of H (2)S on endothelial function in senescence by inhibiting the production of inflammatory molecules. …”
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    Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway: Hydrogen sulfide ameliorates endothelial senescence
  17. 2157
    “…Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attracted much attention. …”
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    Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line
  18. 2158
    “…Altered H4K20me3 in senescence is coupled to H4K16ac and DNA methylation changes in senescence. …”
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    Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
  19. 2159
    “…Recently, lncRNAs have also been implicated to play essential roles in the onset of cellular senescence. Herein, using human primary astrocytes (HPAs), we investigated the role of lncRNA TUG1 in HIV-1 Tat-mediated onset of astrocyte senescence. …”
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    Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence
  20. 2160
    “…Aging, which is characterized by enhanced cell senescence and functional decline of tissues, is a major risk factor for many chronic diseases. …”
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    Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon
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