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2181por Zonari, Alessandra, Brace, Lear E., Al-Katib, Kallie, Porto, William F., Foyt, Daniel, Guiang, Mylieneth, Cruz, Edgar Andres Ochoa, Marshall, Bailey, Gentz, Melissa, Guimarães, Gabriela Rapozo, Franco, Octavio L., Oliveira, Carolina R., Boroni, Mariana, Carvalho, Juliana L.“…Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. …”
Publicado 2023
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2182por Feng, Xu, Wang, Liwen, Zhou, Ruoyu, Zhou, Rui, Chen, Linyun, Peng, Hui, Huang, Yan, Guo, Qi, Luo, Xianghang, Zhou, Haiyan“…Mechanistically, these senescent immune cells secrete abundant S100A8 to inhibit adipose RNA-binding motif protein 3 expression. …”
Publicado 2023
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2183por Morsli, Samir, Henriques, Catarina M., Ellis, Pamela S., Mortiboys, Heather, Baxendale, Sarah, Loynes, Catherine A., Renshaw, Stephen A., Bellantuono, Ilaria“…Senescence drives the onset and severity of multiple ageing‐associated diseases and frailty. …”
Publicado 2023
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2184por D’Incà, Erica, Foresti, Chiara, Orduña, Luis, Amato, Alessandra, Vandelle, Elodie, Santiago, Antonio, Botton, Alessandro, Cazzaniga, Stefano, Bertini, Edoardo, Pezzotti, Mario, Giovannoni, James J, Vrebalov, Julia T, Matus, José Tomás, Tornielli, Giovanni Battista, Zenoni, Sara“…Despite sharing a closer phylogenetic relationship with senescence-related homologs to the NAC transcription factor AtNAP, VviNAC60 complemented the nonripening(nor) mutant phenotype in tomato (Solanum lycopersicum), suggesting a dual role as an orchestrator of both ripening- and senescence-related processes. …”
Publicado 2023
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2185por Ding, Yang-Nan, Wang, Ting-Ting, Lv, Shuang-Jie, Tang, Xiaoqiang, Wei, Zi-Yu, Yao, Fang, Xu, Han-Shi, Chen, Yi-Nan, Wang, Xiao-Man, Wang, Hui-Yu, Wang, He-Ping, Zhang, Zhu-Qin, Zhao, Xiang, Hao, De-Long, Sun, Li-Hong, Zhou, Zhou, Wang, Li, Chen, Hou-Zao, Liu, De-Pei“…Genetic knockout of Sirt6 in mouse vascular smooth muscle cells accelerated TAA formation and rupture, reduced survival, and increased vascular inflammation and senescence after angiotensin II infusion. Transcriptome analysis identified interleukin (IL)-1β as a pivotal target of SIRT6, and increased IL-1β levels correlated with vascular inflammation and senescence in human and mouse TAA samples. …”
Publicado 2023
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2186por chaomurilege, Miyagi, Atsuko, Ishikawa, Toshiki, Yamaguchi, Masatoshi, Murayama, Hideki, Kawai-Yamada, Maki“…The NADK2-deficient mutant (nadk2) was used to analyze the effect of NAD(P)(H) unbalance in the dark-induced leaf senescence. During senescence, WT plants and nadk2 mutants showed a similar reduction in chlorophyll content. …”
Publicado 2023
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2187por Iwasaki, Kanako, Lalani, Benjamin, Kahng, Jiho, Carapeto, Priscila, Sanjines, Stephanie, Hela, Francesko, Abarca, Cristian, Tsuji, Tadataka, Darcy, Justin, Bartke, Andrzej, Tseng, Yu-Hua, Kulkarni, Rohit N., Aguayo-Mazzucato, Cristina“…INTRODUCTION: The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). …”
Publicado 2023
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2188por Storozynsky, Quinn T., Han, Xuefei, Komant, Shae, Agopsowicz, Kate C., Potts, Kyle G., Gamper, Armin M., Godbout, Roseline, Evans, David H., Hitt, Mary M.“…However, following radiotherapy cellular senescence is induced in a portion of GBM cells and it is unknown how the radiation-induced senescent state may impact the therapeutic potential of OVs. …”
Publicado 2023
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2189por Attig, Jan, Pape, Judith, Doglio, Laura, Kazachenka, Anastasiya, Ottina, Eleonora, Young, George R., Enfield, Katey S.S., Aramburu, Iker Valle, Ng, Kevin W., Faulkner, Nikhil, Bolland, William, Papayannopoulos, Venizelos, Swanton, Charles, Kassiotis, George“…Calbindin loss in LUSC cell lines impaired in vitro and in vivo growth and triggered senescence, consistent with a protumor effect. However, calbindin also directly controlled the senescence-associated secretory phenotype (SASP), marked by secretion of CXCL8 and other neutrophil chemoattractants. …”
Publicado 2023
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2190por Lv, Min‐Yi, Cai, Du, Li, Cheng‐Hang, Chen, Junguo, Li, Guanman, Hu, Chuling, Gai, Baowen, Lei, Jiaxin, Lan, Ping, Wu, Xiaojian, He, Xiaosheng, Gao, Feng“…Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer (CRC) remains unclear. …”
Publicado 2023
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2191“…Excessive oxidative stress can induce ovarian senescence and follicular atresia, thereby reducing the reproductive performance. …”
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2192por Grigorian Shamagian, Lilian, Rogers, Russell G., Luther, Kristin, Angert, David, Echavez, Antonio, Liu, Weixin, Middleton, Ryan, Antes, Travis, Valle, Jackelyn, Fourier, Mario, Sanchez, Liz, Jaghatspanyan, Eva, Mariscal, Javier, Zhang, Rui, Marbán, Eduardo“…EVs secreted by young CDCs exert broad-ranging anti-aging effects in aged rodents and in cellular models of human senescence. Our work not only identifies CDC-EVs as possible therapeutic candidates for a wide range of age-related pathologies, but also raises the question of whether EVs function as endogenous modulators of senescence.…”
Publicado 2023
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2193por Sun, Xinpei, Li, Qian, Tang, Yunyi, Hu, Wanjin, Chen, Gengyao, An, Hongguang, Huang, Daoyuan, Tong, Tanjun, Zhang, Yu“…Although metabolic reprogramming is characterized as a hallmark of aging, implications of the crucial glutamate dehydrogenase (GDH) in human senescence remain poorly understood. Here, we report that GDH activity is significantly increased in aged mice and senescent human diploid fibroblasts. …”
Publicado 2023
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2194Influenza Virus-Induced Paracrine Cellular Senescence of the Lung Contributes to Enhanced Viral Loadpor Schulz, Luise, Hornung, Franziska, Häder, Antje, Radosa, Lukáš, Brakhage, Axel A, Löffler, Bettina, Deinhardt-Emmer, Stefanie“…Our study provides new insights into pathomechanisms of virus-induced cellular senescence. Hence, IAV infection induces premature senescence and subsequent infections in senescent cells lead to an increased viral replication.…”
Publicado 2023
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2195por Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep“…Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. …”
Publicado 2023
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2196por Yue, Caifeng, Qian, Yuanmin, Wang, Chang, Chen, Jiewei, Wang, Jing, Wang, Zifeng, Wan, Xiangbo, Cao, Sumei, Zhu, Jingde, Tao, Qian, Yan, Min, Liu, Quentin“…TRIM29 silencing not only limited the growth of NPC cells in vitro and in vivo, but also induced cellular senescence, along with reactive oxygen species (ROS) accumulation. …”
Publicado 2023
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2197“…Cellular senescence is accelerated by hyperglycemia through multiple pathways. …”
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2198por Miyata, Kenichi, Zhou, Xiangyu, Nishio, Mika, Hanyu, Aki, Chiba, Masatomo, Kawasaki, Hiroko, Osako, Tomo, Takeuchi, Kengo, Ohno, Shinji, Ueno, Takayuki, Maruyama, Reo, Takahashi, Akiko“…Cellular senescence and senescence-associated secretory phenotype (SASP) in stromal cells within the tumor microenvironment promote cancer progression. …”
Publicado 2023
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2199por Wörthmüller, Janine, Disler, Simona, Pradervand, Sylvain, Richard, François, Haerri, Lisa, Ruiz Buendía, Gustavo A., Fournier, Nadine, Desmedt, Christine, Rüegg, Curzio“…Upon exposure to TNF-α/IFN-γ, MCF7 MAGI1 KO cells entered a deeper level of quiescence/senescence compared with MCF7 control cells and activated the AKT and MAPK signaling pathways. …”
Publicado 2023
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2200por Du, Jingyi, Cheng, Nan, Deng, Yifan, Xiang, Ping, Liang, Jianfen, Zhang, Zhenye, Hei, Ziqing, Li, Xiang“…Lipopolysaccharide (LPS) was administered to induce senescence of spinal astrocytes in primary cultures in vitro, to explore the potential impacts of senescence on the secretion of proinflammatory factors. …”
Publicado 2023
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