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  1. 2201
    “…In this study, we aimed to investigate how senescence and the senescence-associated secretory phenotype (SASP) affect chondrogenic differentiation of MSCs. …”
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    Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells
  2. 2202
    “…Conversely, restoring PKP2 in inflamed adipocytes rewires E2F signaling towards the re-activation of cell cycle and decreased senescence. Our findings connect the expression of PKP2 in fat cells to the physiopathology of obesity, as well as uncover a previously unknown defect in cell cycle and adipocyte senescence due to impaired PKP2.…”
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    Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence
  3. 2203
    por Schäfer, Daniel
    Publicado 2002
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    'That senescence itself is an illness': a transitional medical concept of age and ageing in the eighteenth century.
  4. 2204
    “…Bazi Bushen, a Chinese‐patented drug with the function of relieving fatigue and delaying ageing, has been proven effective for extenuating skin senescence. To investigate the potential mechanism, senescence‐accelerated mouse prone 6 (SAMP6) was intragastrically administered with Bazi Bushen for 9 weeks to induce skin homeostasis. …”
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    Bazi Bushen alleviates skin senescence by orchestrating skin homeostasis in SAMP6 mice
  5. 2205
    “…Several senescence types have been identified based on the initiating stimulus, such as replicative (RS), stress‐induced (SIS) and oncogene‐induced senescence (OIS). …”
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    Decoding of translation‐regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence
  6. 2206
    “…However, the impacts of soil salinization on senesced leaf stoichiometry are not fully understood. …”
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    Decoupling of nutrient stoichiometry in Suaeda glauca (Bunge) senesced leaves under salt treatment
  7. 2207
    por Gan, Su-Sheng
    Publicado 2022
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    Hypothesis: the subcellular senescence sequence of a mesophyll cell mirrors the cell origin and evolution
  8. 2208
    “…These questions concern i) the exact molecular causes triggering replicative senescence, ii) the role of DNA repair mechanisms and iii) the importance of R-loops at telomeres in regulating senescence onset, and iv) the mechanisms underlying the bypass of replicative senescence. …”
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    The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA
  9. 2209
    “…Stress-induced premature senescence (SIPS) has been implicated in regulating these pathophysiological processes, but whether SIPS contributes to AAA formation remains unknown. …”
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    Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms
  10. 2210
    “…Moreover, senescent MSCs (sMSCs) are characterized by the senescence-messaging secretome (SMS), which is typically manifested by the release of molecules with an adverse effect. …”
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    Rejuvenation of Senescent Mesenchymal Stem Cells to Prevent Age-Related Changes in Synovial Joints
  11. 2211
    “…EPA was applied in stress conditions. The degree of senescence was measured by senescence-associated beta-galactosidase staining and p16 staining using immunofluorescence. …”
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    The Protective Effects of Eicosapentaenoic Acid for Stress-induced Accelerated Senescence in Vascular Endothelial Cells
  12. 2212
    “…Histone acetyltransferase p300 is a transcriptional activator, and its changes can lead to cell senescence. The present study investigated whether CSE can induce the senescence of EPCs by upregulating p300. …”
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    Cigarette smoke extract induces the senescence of endothelial progenitor cells by upregulating p300
  13. 2213
    por Nakashima, Satoru, Yamakita, Eri
    Publicado 2023
    “…Therefore, the leaf senescence started through a slow decrease in chlorophyll a (20–30 days), followed by a rapid increase in anthocyanins (~20 days), followed by a rapid decrease in chlorophyll a (10–20 days). …”
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    In Situ Visible Spectroscopic Daily Monitoring of Senescence of Japanese Maple (Acer palmatum) Leaves
  14. 2214
    “…The senescence-associated secretory phenotype (SASP) is closely associated with the tumorigenesis and progression of intrahepatic cholangiocarcinoma (ICC). …”
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    HELLS modulates the stemness of intrahepatic cholangiocarcinoma through promoting senescence-associated secretory phenotype
  15. 2215
    “…It is a key event leading to senescence, which is characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype (SASP) that includes the expression of inflammatory cytokines. …”
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    DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
  16. 2216
    “…Aging is accompanied by impaired mitochondrial function and accumulation of senescent cells. Mitochondrial dysfunction contributes to senescence by increasing the levels of reactive oxygen species and compromising energy metabolism. …”
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    Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction‐induced cellular senescence in dermal fibroblasts
  17. 2217
    “…Senescent cells exhibit distinct features, including mitochondrial dysfunction and the excessive accumulation and release of reactive oxygen species (ROS), which are highly correlated and lead to a vicious cycle of increasing senescent cells. …”
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    Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
  18. 2218
    “…In vitro GDF11 deletion causes cellular senescence in Neuro-2a cells. Mechanistically, GDF11 deletion induces neuronal senescence via Smad2-induced transcription of the pro-senescence factor p21. …”
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    GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
  19. 2219
    “…Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. …”
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    PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy
  20. 2220
    “…The cardiovascular risk factors, including smoking, ethanol, and oxidative stress, can induce cellular senescence. The senescent cells increase the expression and release of pro-inflammatory molecules and matrix metalloproteinase (MMPs). …”
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    mTOR Inhibitor Rapalink-1 Prevents Ethanol-Induced Senescence in Endothelial Cells
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