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  1. 2301
    por Bertram, C, Hass, R
    Publicado 2009
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    Cellular senescence in human mammary epithelial cells (HMEC) is accompanied by an increase of elastin formation
  2. 2302
    “…The present study aims to investigate whether gastrokine 1 (GKN1) induces senescence and apoptosis in gastric cancer cells by regulating telomere length and telomerase activity. …”
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    Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer
  3. 2303
    “…We investigated the effect of age on resolution by analyzing hippocampal tissue from 2- and 9-month-old senescence-accelerated mouse prone 8 (SAMP8), as well as age-matched senescence-accelerated mouse resistant 1 (SAMR1). …”
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    Insufficient Resolution Response in the Hippocampus of a Senescence-Accelerated Mouse Model — SAMP8
  4. 2304
    “…Previously, two quantitative trait loci (QTLs) associated with early cataract, AMD-like retinopathy, and some behavioral aberrations in senescence-accelerated OXYS rats were uncovered on chromosome 1 in a cross between OXYS and WAG rats. …”
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    Application of quantitative trait locus mapping and transcriptomics to studies of the senescence-accelerated phenotype in rats
  5. 2305
    “…Here, we made the surprising observation that dark-induced leaf senescence was accelerated by the presence of Peps. …”
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    Perception of Arabidopsis AtPep peptides, but not bacterial elicitors, accelerates starvation-induced senescence
  6. 2306
    “…Flow cytometry analysis, immunofluorescence staining for E-cadherin or Ki-67 and senescence associated beta-galactosidase assays assessed breast cancer cell outgrowth and phenotype. …”
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    Lung Epithelial Cells Induce Both Phenotype Alteration and Senescence in Breast Cancer Cells
  7. 2307
    “…Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). …”
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    SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
  8. 2308
    “…Senescent cells secrete a plethora of factors with potent paracrine signaling capacity. …”
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    Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis
  9. 2309
    “…Unexpectedly, we found that the expression of proto-oncogene PIM-1, which can promote tumorigenesis, is induced at transcriptional level during senescence. Inhibition of PIM-1 alleviated both replicative and oncogene-induced senescence. …”
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    PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation
  10. 2310
    “…BACKGROUND: Leaf senescence is an important developmental programmed degeneration process that dramatically affects crop quality and yield. …”
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    Global analysis of the Gossypium hirsutum L. Transcriptome during leaf senescence by RNA-Seq
  11. 2311
    “…In these experiments, Kang et al. (2011) demonstrate the phenomenon of oncogene-induced cellular senescence and immune-mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and 3E). …”
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    Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
  12. 2312
    “…We identified and quantified the occurrence of senescence in adult rat NP cells using senescence-associated-beta-galactosidase (SA-β-Gal) staining. …”
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    Effect of High Glucose on Stress-Induced Senescence of Nucleus Pulposus Cells of Adult Rats
  13. 2313
    “…BACKGROUND: Approximately 10% of women suffer from premature ovarian senescence (POS), ca. 9% as occult primary ovarian insufficiency (OPOI, also called premature ovarian aging, POA) and ca. 1% as primary ovarian insufficiency (POI, also called premature ovarian failure, POF). …”
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    Prospectively assessing risk for premature ovarian senescence in young females: a new paradigm
  14. 2314
    “…Genes that are differentially regulated during cellular senescence refer to pathways involved in neurodegeneration, focal adhesion, actin cytoskeleton, proteasome, cell cycle, DNA replication, and oxidative phosphorylation. …”
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    Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing
  15. 2315
    “…In accordance with that, the senescence of HSPCs also started from the middle age, since the self-renewal and differentiation ability remarkably decreased, and senescence-associated markers SA-β-GAL increased in the 6-month-old and the older groups. …”
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    Study on the Dynamic Biological Characteristics of Sca-1(+) Hematopoietic Stem and Progenitor Cell Senescence
  16. 2316
    “…This decrease was further found to be attributed to senescence. CONCLUSION: Our findings indicated that under harmful conditions, Lcn2 gene is responsible for the regulation of cell survival through senescence.…”
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    The Lcn2-engineered HEK-293 cells show senescence under stressful condition
  17. 2317
    “…NHS-IL12 induced pronounced cancer cell senescence, as documented by strong expression of senescence-associated p16(INK4a) and nuclear translocation of p-HP1γ, and permanent arrest of cancer cell proliferation. …”
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    Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation
  18. 2318
    “…Furthermore, we uncover a novel form of haploinsufficiency-induced senescence (HIS) specific to epithelial cells, which is triggered by pRb pathway activation rather than p53 induction. …”
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    Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
  19. 2319
    “…Failure to maintain telomeres leads to their progressive erosion and eventually triggers replicative senescence, a pathway that protects against unrestricted cell proliferation. …”
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    Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages
  20. 2320
    “…Premature leaf senescence has a negative influence on the yield and quality of cotton, and several genes have been found to regulate leaf senescence. …”
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    A novel NAP member GhNAP is involved in leaf senescence in Gossypium hirsutum
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