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  1. 2321
    “…Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). …”
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    mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
  2. 2322
    “…Autophagy and senescence have been described as central features of cell biology, but the interplay between these mechanisms remains obscure. …”
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    Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage
  3. 2323
    “…Furthermore, IGF-I-treated cells showed increased senescence-associated β-galactosidase activity and expression of p53 and p21 protein. …”
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    Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence
  4. 2324
    “…Cellular senescence, the stable cell cycle arrest elicited by various forms of stress, is an important facet of tumor suppression. …”
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    Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence
  5. 2325
    por Walen, Kirsten H.
    Publicado 2008
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    Meiotic-Like Division to a Aneuploidy: Chromosomal Instability (CIN), Cell-Senescence and Cancer
  6. 2326
    “…In this study, we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis. The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.…”
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    DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis
  7. 2327
    por Yang, Yafan, Li, Shuangshuang
    Publicado 2015
    “…In addition, dandelion extracts significantly protected HDFs from H(2)O(2)-induced cellular senescence. In conclusion, dandelion extracts especially leaf and flower extracts are potent protective agents against UVB damage and H(2)O(2)-induced cellular senescence in HDFs by suppressing ROS generation and MMP activities and helping UVB absorption.…”
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    Dandelion Extracts Protect Human Skin Fibroblasts from UVB Damage and Cellular Senescence
  8. 2328
    “…This pathway plays an important role in KA progression by promoting proliferation and activation of oncogenic-induced senescence.…”
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    Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
  9. 2329
    “…We observe two types of senescence in regenerating muscle; a transient senescence in non-myogenic cells of control and Numb mutant mice that partly depends on INK4a/ARF activity, and a persistent senescence in myogenic cells lacking Numb. …”
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    Numb is required to prevent p53-dependent senescence following skeletal muscle injury
  10. 2330
    “…Thus, the consideration of stay-green or senescence phenotypes is still an ongoing debate and has not been comprehensively addressed. …”
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    Staying Alive or Going to Die During Terminal Senescence—An Enigma Surrounding Yield Stability
  11. 2331
    “…To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick’s limit. …”
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    Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy
  12. 2332
    “…However, the escape from senescence and cancer cell repopulation give rise to some doubts concerning the effectiveness of the senescence-induced anticancer therapy. …”
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    Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence()
  13. 2333
    “…Senescence associated beta-galactosidase (SA-beta-Gal) staining was used to evaluate premature senescence in the endothelium of corneal allografts. …”
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    Oxidative stress and premature senescence in corneal endothelium following penetrating keratoplasty in an animal model
  14. 2334
    “…Since replicative senescence and SIPS occur over many days and many population doublings of the mass cultures of primary cells used to study senescence, the sequence of events that occur downstream of senescence signaling can be challenging to define. …”
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    Aging with ING: a comparative study of different forms of stress induced premature senescence
  15. 2335
    “…RESULTS: We observed that BubR1(+/−)SGO(+/−) MEFs had an accelerated cellular senescence characterized by morphological changes and expressed senescence-associated β-galactosidase. …”
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    Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
  16. 2336
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    The reproductive advantages of a long life: longevity and senescence in wild female African elephants
  17. 2337
    “…The phytohormone cytokinin (CK) is known to delay senescence in plants. We studied the effect of a CK analog, 6-benzyl adenine (BA), on rice leaves to understand the possible mechanism by which CK delays senescence in a drought- and heat-tolerant rice cultivar Nagina22 (N22) using dark-induced senescence (DIS) as a surrogate for natural senescence of leaves. …”
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    Cytokinin delays dark-induced senescence in rice by maintaining the chlorophyll cycle and photosynthetic complexes
  18. 2338
    “…Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility and cell proliferation and that their loss leads to cell-cycle arrest and cellular senescence. This phenotype arises from down-regulation of the essential cell-cycle proteins CyclinA, CKS1 and CDK1. …”
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    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis
  19. 2339
    “…Taken together, our results demonstrate a role for BRE in both replicative senescence and DNA damage-induced premature senescence. …”
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    BRE plays an essential role in preventing replicative and DNA damage-induced premature senescence
  20. 2340
    “…Nanog transduction into primary fibroblasts results in suppression of senescence-associated β-galactosidase activity. Investigation of cell cycle factors revealed that transient activation of Nanog correlates with consistent downregulation of the cell cycle inhibitor p27(KIP1) (also known as CDKN1B). …”
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    Nanog induces suppression of senescence through downregulation of p27(KIP1) expression
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