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  1. 2341
    “…CONCLUSIONS: We explored proteomic profile changes in cell culture-induced senescent cells and built senescence-associated molecular networks, which will help to elucidate the mechanisms of senescence in human proximal tubule epithelial cells.…”
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    Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells
  2. 2342
    “…After proton irradiation, a subset of SIR genes (Troy, Sox17, Opg, Faim2, Lpo, Tlr2 and Ptges) and a gene known to be involved in invasiveness (Plat), along with the senescence associated gene (P19Arf) are markedly increased. …”
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    Radiation Promotes Colorectal Cancer Initiation and Progression by Inducing Senescence-Associated Inflammatory Responses
  3. 2343
    “…The aging heart was reported to show greater cardiac damage after I/R injury than that observed in young hearts. Senescence marker protein 30 (SMP30), whose expression decreases with age, plays a role in reducing oxidative stress and apoptosis. …”
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    Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion
  4. 2344
    “…Cellular senescence correlates with changes in the transcriptome. …”
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    Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq
  5. 2345
    “…In agreement with these findings, treatment with metformin decreased cellular senescence in several senescence models in a DICER1‐dependent manner. …”
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    Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence
  6. 2346
    “…Persistent DNA damage is considered as a main cause of cellular senescence induced by ionizing radiation. However, the molecular bases of the DNA damage and their contribution to cellular senescence are not completely clear. …”
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    Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation
  7. 2347
    “…The mechanism underlying senescence of non-climacteric fruit is poorly understood. …”
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    Proteomic Analysis of Differentially Expressed Proteins Involved in Peel Senescence in Harvested Mandarin Fruit
  8. 2348
    por Yanai, Shuichi, Endo, Shogo
    Publicado 2016
    “…This data article contains the supporting information for the research article entitled “Early onset of behavioral alterations in senescence-accelerated mouse prone 8 (SAMP8)” [1]. Senescence-accelerated mouse prone 8 (SAMP8), which originally developed from AKR/J mice, shows learning and memory impairments at the age of 8–12 months. …”
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    Data on the optimization of behavioral tasks for senescence-accelerated mouse prone 8 (SAMP8)
  9. 2349
    “…Manual inspection of senescence, however, is time consuming, inaccurate and subjective. …”
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    Quantifying the Onset and Progression of Plant Senescence by Color Image Analysis for High Throughput Applications
  10. 2350
    “…WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203580. …”
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    Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts
  11. 2351
    por Kim, Hye Kyung
    Publicado 2016
    “…Ultraviolet (UV) irradiation generates reactive oxygen species (ROS) in the cells, which induces the cellular senescence and photoaging. The present study investigated the protective effects of garlic on photo-damage and cellular senescence in UVB-exposed human keratinocytes, HaCaT cells. …”
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    Protective Effect of Garlic on Cellular Senescence in UVB-Exposed HaCaT Human Keratinocytes
  12. 2352
    “…In addition, we have found that NS1643 produced a strong inhibition of cell proliferation by activating a cellular senescence program. Furthermore, inhibition of autophagy via siRNA targeting AMPK or treatment with hydroxychloroquine an autophagy inhibitor activates apoptosis in NS1643-treated cells. …”
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    Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma
  13. 2353
    “…Senescence, a persistent form of cell cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. …”
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    NOTCH1 mediates a switch between two distinct secretomes during senescence
  14. 2354
    “…For bread wheat (Triticum aestivum), the transition from vegetative to reproductive growth, the start and rate of leaf senescence and the relative timing of different stages of flowering and grain filling all contribute to plant performance. …”
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    Determining Phenological Patterns Associated with the Onset of Senescence in a Wheat MAGIC Mapping Population
  15. 2355
    “…Polyploidy was detected by propidium iodide staining and metaphase spread. Cellular senescence was determined by β-galactosidase staining and senescence-associated secretory cytokine analysis. …”
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    MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
  16. 2356
    “…Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. …”
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    SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer
  17. 2357
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    The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma
  18. 2358
    “…Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF). …”
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    HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci
  19. 2359
    “…The G1-arrested cells showed increase in cytosolic senescence-associated-β-galactosidase (SA-β-Gal) activity, a biomarker of cellular senescence. …”
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    Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells
  20. 2360
    “…BACKGROUND: Augmented arginase-II (Arg-II) is implicated in endothelial senescence and inflammation through a mutual positive regulatory circuit with S6K1. …”
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    Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling
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