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  1. 2521
    “…Similarly, salivary gland-derived organoids show increased expression of senescence markers and pro-inflammatory senescence-associated secretory phenotype (SASP) factors after radiation exposure. …”
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    Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
  2. 2522
    “…In the present study, we tested the ability of D-galactose (D-gal), a reducing sugar, to induce senescence in glioblastoma cells. Following pretreatment with D-gal, glioblastoma cell lines (C6 and U87MG) showed typical characteristics of senescence. …”
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    D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway
  3. 2523
    “…Younger patients were more sensitive to warfarin-related AC than older patients, which was possibly due to accumulated warfarin-induced cellular senescence.…”
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    Warfarin Accelerates Aortic Calcification by Upregulating Senescence-Associated Secretory Phenotype Maker Expression
  4. 2524
    “…Extended culture time of MSC increases their senescent levels, leading to a critical loss of cell fitness. …”
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    Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures
  5. 2525
    “…Here, tumor therapy inactivates the cells by inducing senescence. Therefore, study focused whether senescence is a stimulus for non-professional phagocytosis or whether senescent cells themselves phagocytize non-professionally. …”
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    Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
  6. 2526
    “…Leaf senescence, accompanied by chlorophyll breakdown, chloroplast degradation and inhibition of photosynthesis, can be suppressed by an exogenous application of cytokinins. …”
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    The Anti-Senescence Activity of Cytokinin Arabinosides in Wheat and Arabidopsis Is Negatively Correlated with Ethylene Production
  7. 2527
    por Torrance, Jerry B., Goldband, Steve
    Publicado 2020
    “…In this paper, we extend this idea to make an actual calculation of the predicted mortality rate caused by short telomere length induced senescence (STLIS). We derive a simple equation for the mathematical relationship between telomere length and mortality rate. …”
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    Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data
  8. 2528
    por Kim, Da Yeon, Lee, Minyoung, Kim, Eun Ju
    Publicado 2021
    “…In view of the finding that senescence is typically increased post-irradiation, the present study examined whether ionizing radiation may cause kidney injury by enhancing premature senescence. …”
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    Involvement of Klotho, TNF-α and ADAMs in radiation-induced senescence of renal epithelial cells
  9. 2529
    “…Our study provides one of the first examples of functional senescence in song, offering new insights into avian senescence. …”
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    Senescence of song revealed by a long-term study of the Seychelles warbler (Acrocephalus sechellensis)
  10. 2530
    “…The alterations indicate a reduced ability of senescent peritubular cells to contract and secrete proteins, as well as disturbances in nuclear factor (NF)-κB signaling and a reduced capacity to handle reactive oxygen species. …”
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    Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model
  11. 2531
    “…Due to the decreased muscle mass and fiber size, 40-week-old senescence accelerated mouse prone 8 (SAMP8) mice were used as a sarcopenia model, in whose muscles the iron content and markers of ferroptosis were found to increase, compared to 8-week- old SAMP8 controls. …”
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    Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)
  12. 2532
    “…The dihydroethidium (DHE) staining assay was used to measure intracellular levels of reactive oxidative species (ROS), and a senescence β-galactosidase assay kit was used to determine endothelial senescence. …”
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    GPR120 Agonist GW9508 Ameliorated Cellular Senescence Induced by ox-LDL
  13. 2533
    “…Cellular and vascular senescence was assessed by analysis of the senescence‐associated β‐galactosidase (SA‐β‐gal) and expression of senescence markers P16, P21, P53, TERT and TRF1. …”
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    YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR
  14. 2534
    “…Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). …”
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    Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype
  15. 2535
    “…Most of these effects are implicated with cellular senescence. Therefore, the present study aimed to determine the effect of carbofuran on cellular senescence and biological ageing. …”
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    Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish
  16. 2536
    por Gala, Dhir Niren, Fabian, Zsolt
    Publicado 2021
    “…Here, we review current literature data on the effects of hypoxia on bone marrow-derived mesenchymal stromal cells, one of the most popular tools of practical cellular therapy, in the context of their senescence.…”
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    To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence
  17. 2537
    “…As the last step of leaf development, senescence is a molecular process involving cell death mechanism. …”
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    ACCELERATED CELL DEATH 6 Acts on Natural Leaf Senescence and Nitrogen Fluxes in Arabidopsis
  18. 2538
    por Sławińska, Natalia, Krupa, Renata
    Publicado 2021
    “…Cells can become senescent in response to stress. Senescence is a process characterised by a stable proliferative arrest. …”
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    Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin
  19. 2539
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    Senescent Cells: A Potential Target for New Cancer Therapies in Older Oncologic Patients
  20. 2540
    “…Cellular senescence is induced by stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. …”
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    Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
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