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  1. 2541
    “…Although the senescent cells are growth arrested, they still demonstrate high metabolic rate and altered gene expressions, indicating that senescent cells are still active. …”
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    Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
  2. 2542
    “…Aging can render tendon stem/progenitor cells (TSCs) into premature senescence. We investigated the effects of rapamycin, a specific mTOR inhibitor, on the senescence of TSCs. …”
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    Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
  3. 2543
    “…A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP). …”
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    Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype
  4. 2544
    “…The inhibition of mitophagy can promote bone marrow mesenchymal stem cells (BMSCs) senescence, and increasing studies have shown that interventions targeting BMSCs senescence can ameliorate osteoporosis, exhibiting their potential for use as therapeutic strategies. …”
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    Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis
  5. 2545
    “…Senescent cells produce chronic inflammation that contributes to the diseases and debilities of aging. …”
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    Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes
  6. 2546
    “…Senescence, a state of stable growth arrest, plays an important role in ageing and age‐related diseases in vivo. …”
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    Early growth response 2 (EGR2) is a novel regulator of the senescence programme
  7. 2547
    “…Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation.…”
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    Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
  8. 2548
    “…Therefore, our data suggest that overexpression of H2A.Z isoforms enables cells to overcome the oncoprotective barrier associated with senescence, favoring PDAC tumor grow and chemoresistance. …”
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    H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma
  9. 2549
    “…Instead, a zone with defence responses and premature senescence occurred and symbiosome development gets arrested. …”
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    NIN is essential for development of symbiosomes, suppression of defence and premature senescence in Medicago truncatula nodules
  10. 2550
    “…This study shows the distribution patterns of apoptotic cells and biomarkers of cellular senescence during the ontogeny of the retina in the zebra finch (T. guttata). …”
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    Analysis of Programmed Cell Death and Senescence Markers in the Developing Retina of an Altricial Bird Species
  11. 2551
    “…Solar ultraviolet A (UV-A) radiation promotes a huge variety of damages on connective tissues and dermal fibroblasts, including cellular senescence, a major contributor of skin photoaging. …”
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    4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation
  12. 2552
    “…Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of pro‐inflammatory cytokines and molecules. …”
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    The struggle of a good friend getting old: cellular senescence in viral responses and therapy
  13. 2553
    “…BACKGROUND & AIMS: Cholangiocyte senescence is important in the pathogenesis of primary sclerosing cholangitis (PSC). …”
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    Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2(-/-) mouse
  14. 2554
    “…BMP5 knockdown also decreased chondrocyte apoptosis and senescence by suppressing the activation of p38 and ERK MAP kinases. …”
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    BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice
  15. 2555
    “…The mechanisms and clinical significance of the cellular senescence of tumor cells are a matter of ongoing debate. …”
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    Patient-Specific Variables Determine the Extent of Cellular Senescence Biomarkers in Ovarian Tumors In Vivo
  16. 2556
    por Osiewacz, Heinz D., Schürmanns, Lea
    Publicado 2021
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    A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence in Podospora anserina
  17. 2557
    “…COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). …”
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    COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
  18. 2558
    “…A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to assess the viability of treated cells, while senescence was assessed by senescence-associated-β-galactosidase staining. …”
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    Triphala extract negates arecoline-induced senescence in oral mucosal epithelial cells in vitro
  19. 2559
    “…Abnormally accelerated, premature placental senescence plays a crucial role in the genesis of pregnancy pathologies. …”
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    Molecular Pathways of Cellular Senescence and Placental Aging in Late Fetal Growth Restriction and Stillbirth
  20. 2560
    “…Pathways involved in senescence may represent viable treatment targets of post-concussive syndrome. …”
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    Early onset senescence and cognitive impairment in a murine model of repeated mTBI
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