“…Aging leads to a high burden on society, both medically and economically. Cellular senescence plays an essential role in the initiation of aging and age-related diseases. …”
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“…In a recent issue of Cell, Lowe and collaborators(1) have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8(+) T cells.…”
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“…Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). …”
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“…These characteristics of senescent fibroblasts establish a close link between cellular senescence and IPF. …”
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“…Here, we demonstrate that proteostasis decline is intrinsic to human senescence. Using transcriptome-wide characterization of gene expression, splicing, and translation, we found a significant deterioration in the transcriptional activation of the heat shock response in stressed senescent cells. …”
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“…Some viruses are able to exploit the senescence program to improve their replication, while others have developed strategies to subvert senescence. …”
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“…A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. …”
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“…Mammalian development involves an exquisite choreography of cell division, differentiation, locomotion, programmed cell death, and senescence that directs the transformation of a single cell zygote to a mature organism containing on the order of 40 trillion cells in humans. …”
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“…Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. …”
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“…Cellular senescence is a state of stable cell cycle arrest that can be triggered in response to various insults and is characterized by distinct morphological hallmarks, gene expression profiles, and the senescence-associated secretory phenotype (SASP). …”
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“…In recent years, significant progress has been made in the field of leaf senescence to elucidate the role of light in the regulation of nuclear gene expression at the molecular level during the senescence phase. …”
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“…The study also addresses the rationale and potential for therapeutic interventions based on the clearance of senescent cells or suppression of the senescence‐associated secretory phenotype. © 2021 The Authors. …”
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“…Therefore, this review aims at investigating how senescence could lead to changes in the structure and function of the lymphatic vessels. …”
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“…Cellular senescence and aging result in a reduced ability to manage persistent types of inflammation. …”
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“…Senescence is a highly quantitative trait, but in wheat the genetics underpinning senescence regulation remain relatively unknown. …”
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“…Consequently, the literature contains multiple descriptions and categorisations of microglia with neurotoxic phenotypes, including senescence, without any unifying markers. The role of microglia in brain homeostasis, particularly iron storage and metabolism, may provide a key to reliable identification.…”
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“…Leaf senescence, which is the last developmental phase of plant growth, is controlled by multiple genetic and environmental factors. …”
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“…Bacteria have been thought to flee senescence by dividing into two identical daughter cells, but this notion of immortality has changed over the last two decades. …”
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“…Senescent cells secrete a specific set of pro-inflammatory mediators, referred to as a senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure and function. …”
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