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2581
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2582por Kitakaze, Masatoshi, Chijimatsu, Ryota, Vecchione, Andrea, Kitagawa, Toru, Doki, Yuichiro, Eguchi, Hidetoshi, Ishii, Hideshi“…Consequently, age-related cell transformation leads to cancer and cell degeneration (senescence). This article aims to describe current advances in the genomic mechanisms of senescence and its role in the spatiotemporal spread of epithelial clones and cell evolution.…”
Publicado 2021
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2583por Shimazaki, Reiri, Takano, Shigetsugu, Satoh, Mamoru, Takada, Mamoru, Miyahara, Yoji, Sasaki, Kosuke, Yoshitomi, Hideyuki, Kagawa, Shingo, Furukawa, Katsunori, Takayashiki, Tsukasa, Kuboki, Satoshi, Sogawa, Kazuyuki, Motohashi, Shinichiro, Nomura, Fumio, Miyazaki, Masaru, Ohtsuka, Masayuki“…CFB knockdown induced increases in the number of senescence-associated-β-galactosidase (SA-β-gal) positive cells exhibiting p21 expression upregulation, which promotes cellular senescence with cyclinD1 accumulation. …”
Publicado 2021
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2584por Suvakov, Sonja, Ghamrawi, Ranine, Cubro, Hajrunisa, Tu, Haitao, White, Wendy M., Tobah, Yvonne S. Butler, Milic, Natasa M., Grande, Joseph P., Cunningham, Julie M., Chebib, Fouad T., Prata, Larissa G.P. Langhi, Zhu, Yi, Tchkonia, Tamara, Kirkland, James L., Nath, Karl A., Milosavljevic, Aleksandar, Garovic, Vesna D.“…We postulate that accelerated ageing in general, and particularly cellular senescence, play a role in its pathophysiology. METHODS: We compared women with preeclampsia vs. normotensive pregnancies with respect to epigenetic markers of ageing and markers of senescence in tissues/organs affected by preeclampsia (blood, urine, adipose tissue, and kidney). …”
Publicado 2021
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2585por Fooladvand, Farnoosh, Tahouri, Vida, Baeeri, Maryam, Minaei, Tayebeh, Rahimifard, Mahban, Hodjat, Mahshid, Khorasani, Reza, Haghi-Aminjan, Hamed, Abdollahi, MohammadEnlace del recurso
Publicado 2021
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2586
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2587por Chen, Shuai, Gong, Yu, Shen, Yu, Liu, Yu, Fu, Yue, Dai, Yi, Rehman, Adeel ur, Tang, Liming, Liu, Hanyang“…Results showed that Inhibin beta A (INHBA) was sorted out as a senescence-related factor and a prognostic predictor in CRC. …”
Publicado 2021
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2588por Mai, Liping, He, Guodong, Chen, Jing, Zhu, Jiening, Chen, Shaoxian, Hou, Xinghua, Yang, Hui, Zhang, Mengzhen, Wu, Yueheng, Lin, Qiuxiong, Yang, Min, Li, Xiaohong“…METHODS: Hypoxia in hBMSCs was induced for 0, 4, and 12 hours, and cellular senescence was evaluated by senescence-associated β-galactosidase (SA-β-gal) staining. …”
Publicado 2021
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2589por Malerba, Helena Nascimento, Pereira, Arthur Antonio Ruiz, Pierrobon, Marcela Favoretto, Abrao, Guilherme Souza, Toricelli, Mariana, Akamine, Eliana Hiromi, Buck, Hudson Sousa, Viel, Tania Araujo“…To elucidate this relationship better, this study aimed to evaluate whether the chronic combination of these two strategies could increase healthy aging in Senescence Accelerated Mouse-Prone 8 (SAMP8). Animals were submitted to either one or both of these strategies until the age of 10 months when they were anesthetized and killed and their hippocampus was extracted. …”
Publicado 2021
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2590por St-Jean, Stéphanie, De Castro, Ariane Cristina, Lecours, Mia, Jones, Christine, Rivard, Nathalie, Rodier, Francis, Perreault, Nathalie, Boudreau, François“…Thus, NCOR1 plays a novel role in preventing cancer-associated senescence and could represent a target for controlling colon cancer progression. …”
Publicado 2021
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2591por Baek, Kyung-Wan, Jung, Youn-Kwan, Park, Jin Sung, Kim, Ji-Seok, Hah, Young-Sool, Kim, So-Jeong, Yoo, Jun-Il“…Though it is less frequently used, the senescence-accelerated mouse can also be useful for sarcopenia research. …”
Publicado 2021
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2592“…RESULTS: The application of H(2)O(2) significantly increased (p<0.05) the degree of senescence and apoptosis of cultured INS-1 β-cells. …”
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2593por Lee, Yeonghyeon, Kim, Jaejin, Jeon, Taerang, Roh, Kyeonghwan, Kim, Mi-Sung, Kang, Chanhee“…Senescent cells constantly experience stressful conditions and restrain their protein translation to cope with it. …”
Publicado 2021
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2594por Chen, Dan-Dan, Peng, Xuyan, Wang, Yuxuan, Jiang, Mingjun, Xue, Mengjiao, Shang, Guohui, Liu, Xuhui, Jia, Xiaolin, Liu, Baixue, Lu, Yingwei, Mu, Hongmei, Zhang, Fengyan, Hu, Yanzhong“…Here, we reported that HSP90 acts as a senomorphic target of senescent RPE cells in vitro. Using H(2)O(2)-induced senescent ARPE-19 cells and replicative senescent primary RPE cells from rhesus monkey, we found that HSP90 upregulates the expression of IKKα, and HIF1α in senescent ARPE-19 cells and subsequently controls the induction of distinct senescence-associated inflammatory factors. …”
Publicado 2021
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2595por Giordani, Chiara, Silvestrini, Andrea, Giuliani, Angelica, Olivieri, Fabiola, Rippo, Maria Rita“…Disruption at any stage in their metabolism, dynamics and bioenergetics could lead to the production of considerable amounts of reactive oxygen species and increased mitochondrial permeability, which are among the hallmarks of cellular senescence. Extensive changes in mitomiR expression and distribution have been demonstrated in senescent cells, those could possibly lead to an alteration in mitochondrial homeostasis. …”
Publicado 2021
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2596por Rivas-Chacón, Luz del Mar, Martínez-Rodríguez, Sofía, Madrid-García, Raquel, Yanes-Díaz, Joaquín, Riestra-Ayora, Juan Ignacio, Sanz-Fernández, Ricardo, Sánchez-Rodríguez, Carolina“…Oxidative stress is an essential factor in developing ARHL; additionally, premature senescence of auditory cells induced by oxidative stress can produce hearing loss. …”
Publicado 2021
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2597por Herrmann, Anja L., Kuhn, Bianca J., Holzer, Angela, Krijgsveld, Jeroen, Hoppe-Seyler, Karin, Hoppe-Seyler, Felix“…In these cells, CPX can induce apoptosis, a form of cell death, or senescence, an irreversible cellular growth arrest. …”
Publicado 2021
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2598por Chen, Minhao, Li, Yingjuan, Xiao, Longfei, Dai, Guangchun, Lu, Panpan, Rui, Yunfeng“…Although studies have demonstrated that tendon aging is closely associated with the altered TSPCs function on senescence, the cellular and molecular mechanisms of TSPCs senescence remain largely unknown. …”
Publicado 2021
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2599por Saleh, Tareq, El-Sadoni, Mohammed, Alhesa, Ahmad, Awad, Heyam, Jaradat, Mahmoud, Al-Hazaimeh, Mohammad, Dawoud, Rand, Mryyian, Amel, Azab, Bilal“…Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.…”
Publicado 2021
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2600“…TMZ enhanced the autophagic response and senescence, which was mediated via the p53 and p21 pathways. …”
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