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  1. 2621
  2. 2622
    “…The presence of specific cytokines in the tumor microenvironment has been shown to induce senescence in tumor cells. Subsequently, tumor cells acquire a senescence-associated secretory phenotype that strongly modulates anti-tumor responses. …”
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  3. 2623
    “…Moreover, the persistent stimulation by several antigens throughout life favors the switching of CD8(+) T cells towards a senescent phenotype contributing to a low-grade inflammation that is a major component of several ageing-related diseases. …”
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  4. 2624
    “…The recent finding of the genetic interaction of WRKY53, a key senescence-related gene with REVOLUTA, a master regulator of early leaf patterning, raises the question of how early and late developmental events are connected. …”
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  5. 2625
    “…Polo-like kinase 1 (PLK1) plays numerous roles in the cell cycle, including in cell proliferation and senescence. To investigate the involvement of PLK1 in IVDD, we used patient tissues and an animal model of IVDD. …”
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  6. 2626
    “…Several processes during leaf senescence require coordinated regulation by senescence regulatory genes. …”
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  7. 2627
    “…Unexpectedly, this phenotype was mainly attributed to a transcription-independent role of BMAL1 in stabilizing heterochromatin and thus preventing activation of the LINE1-cGAS-STING pathway. In senescent primate MPCs, we observed decreased capacity of BMAL1 to bind to LINE1 and synergistic activation of LINE1 expression. …”
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  8. 2628
    “…Although the involvement of cellular senescence, a critical component of aging, was suggested in studies of DM1 patient-derived cells, the detailed mechanism of cellular senescence caused by CUG(exp) RNA remains unelucidated. …”
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  9. 2629
  10. 2630
    “…Leaf senescence is a developmentally programmed cell death process that is influenced by a variety of endogenous signals and environmental factors. …”
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  11. 2631
    “…As anticipated, markers of cellular senescence were elevated in old isochronically-paired mice relative to young controls. …”
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  12. 2632
    “…Current methods in measuring maize (Zea mays L.) southern rust (Puccinia polyspora Underw.) and subsequent crop senescence require expert observation and are resource-intensive and prone to subjectivity. …”
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  13. 2633
    “…GSEA indicated that the RAGE‐related differential genes were mainly enriched in senescence‐related pathways. Besides, the RAGE expression was significantly associated with senescence‐related genes. …”
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  14. 2634
    “…In forage crops, age-dependent and stress-induced senescence reduces forage yield and quality. Therefore, delaying leaf senescence may be a way to improve forage yield and quality as well as plant resilience to stresses. …”
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  15. 2635
    “…These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes an important response to injury in the liver. …”
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  16. 2636
    “…We conclude that while elevated temperatures directly cause mitochondrial damage, senescence is induced by elevated ROS levels. We suggest that heat shock alters cell and tissue homeostasis by several independent mechanisms; however, reducing tissue senescence will reduce damage and provide a pathway to overcome physiological challenges in animals.…”
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  17. 2637
    “…The SD ecotype has dark green leaves, short and flat leaves, and more conspicuous taproots, and the XJ ecotype had greater biomass and showed clear signs of senescence or leaf shedding with age. After 2-DE separation and ESI-MS/MS identification, between 25 and 28 differentially expressed protein spots were identified in shoots and roots, respectively. …”
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  18. 2638
    “…It is well established that endogenous hormones regulate the senescence process, but their molecular mechanism in flower senescence remains unclear. …”
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  19. 2639
  20. 2640
    “…According to the carbon sink limitation hypothesis, senescence is regulated by the interplay between plant carbon source and sink dynamics, so that senescence occurs later upon low carbon inputs (source) and earlier upon low carbon demand (sink). …”
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