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  1. 2661
    “…Inducing senescence in cancer cells is emerging as a new therapeutic strategy. …”
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    Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
  2. 2662
    “…Purpose: Features of cellular senescence have been described in diabetic retinal vasculature. …”
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    Long term high glucose exposure induces premature senescence in retinal endothelial cells
  3. 2663
    “…BACKGROUND: Cellular senescence (CS) is an alternative procedure that replaces or reinforces inadequate apoptotic responses and is used as an influencing factor for a variety of cancers. …”
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    Subtype Classification and Prognosis Signature Construction of Osteosarcoma Based on Cellular Senescence-Related Genes
  4. 2664
    “…The mechanisms underlying the therapeutic efficacy of PD-L1 targeting have not been well-established. Cellular senescence has been considered a pivotal mechanism to prevent cancer progression, and recently, PD-L1 inhibition was shown to be involved in cancer cell senescence. …”
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    STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells
  5. 2665
    “…METHODS: We first evaluated autophagy level of senescent TCR‐Ts, and then the senescent TCR‐Ts were expanded in vitro for 7 days with and without spermidine treatment, respectively. …”
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    Autophagic flux restoration of senescent T cells improves antitumor activity of TCR‐engineered T cells
  6. 2666
    “…Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated serine/threonine kinase (ATM) and Rad3-related serine/threonine kinase (ATR), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. …”
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    DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology
  7. 2667
    “…They developed a characteristic senescence phenotype and expressed various senescence markers. …”
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    Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts
  8. 2668
    “…In addition, mTOR inhibitors abrogated ERG-dependent senescence resistance. These studies reveal a previously unappreciated function whereby ERG expression primes preneoplastic cells for the accumulation of additional gene mutations by suppression of oncogene-induced senescence.…”
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    TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence
  9. 2669
    por Milardi, Giulia, Di Lorenzo, Biagio, Gerosa, Jolanda, Barzaghi, Federica, Di Matteo, Gigliola, Omrani, Maryam, Jofra, Tatiana, Merelli, Ivan, Barcella, Matteo, Filippini, Matteo, Conti, Anastasia, Ferrua, Francesca, Pozzo Giuffrida, Francesco, Dionisio, Francesca, Rovere‐Querini, Patrizia, Marktel, Sarah, Assanelli, Andrea, Piemontese, Simona, Brigida, Immacolata, Zoccolillo, Matteo, Cirillo, Emilia, Giardino, Giuliana, Danieli, Maria Giovanna, Specchia, Fernando, Pacillo, Lucia, Di Cesare, Silvia, Giancotta, Carmela, Romano, Francesca, Matarese, Alessandro, Chetta, Alfredo Antonio, Trimarchi, Matteo, Laurenzi, Andrea, De Pellegrin, Maurizio, Darin, Silvia, Montin, Davide, Marinoni, Maddalena, Dellepiane, Rosa Maria, Sordi, Valeria, Lougaris, Vassilios, Vacca, Angelo, Melzi, Raffaella, Nano, Rita, Azzari, Chiara, Bongiovanni, Lucia, Pignata, Claudio, Cancrini, Caterina, Plebani, Alessandro, Piemonti, Lorenzo, Petrovas, Constantinos, Di Micco, Raffaella, Ponzoni, Maurilio, Aiuti, Alessandro, Cicalese, Maria Pia, Fousteri, Georgia
    Publicado 2022
    “…A group of patients showed a high frequency of cTfh1 cells and a prominent expression of PD‐1 and ICOS as well as a cTfh mRNA signature consistent with highly activated, but exhausted, senescent, and apoptotic cells. Plasmatic CXCL13 levels were elevated in this group and positively correlated with cTfh1 cell frequency and PD‐1 levels. …”
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    Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency
  10. 2670
    “…In our previous study, endometriotic lesions were implicated in cellular senescence as their inflammatory pattern could potentially compromise surrounding tissue integrity, thereby inducing a senescent state in cells. …”
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    Colocalization of senescent biomarkers in deep, superficial, and ovarian endometriotic lesions: a pilot study
  11. 2671
    “…Is xanthine dehydrogenase involved in regulating leaf senescence? A recessive early senescence mutant with excess sugar accumulation, ossac3, was isolated previously by screening the EMS-induced mutant library. …”
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    Mutation of OsSAC3, Encoding the Xanthine Dehydrogenase, Caused Early Senescence in Rice
  12. 2672
    “…Floral development and senescence are a crucial determinant for economic and ornamental value. …”
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    Identification and Characterization of Circular RNAs Involved in the Flower Development and Senescence of Rhododendron delavayi Franch
  13. 2673
    “…Consequently, extensive cell expansion is necessary, which may eventually lead to replicative senescence. Considering that micro-structured surfaces with anisotropic topography may promote endothelialization, we investigated the impact of gratings on the biomechanical properties and the replicative capacity of senescent ECs. …”
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    Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells
  14. 2674
    “…In addition, patients had lower mitochondrial biogenesis (PGC-1α and PGC-1β) and higher load of a cellular senescence marker in postmortem prefrontal cortex tissue, with DLB showing the highest effect among the patient groups. …”
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    Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson’s disease and Lewy body dementia
  15. 2675
    “…CONCLUSIONS: BZBS improves cognitive deficits via inhibition of cellular senescence and microglia activation. This study provides experimental evidence for the wide application of BZBS in clinical practice for cognitive deficits.…”
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    Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence
  16. 2676
    “…Cell senescence is one of the most important forms of injury induced by cardiovascular and other ischemic diseases. …”
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    Oxygen–Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11
  17. 2677
    “…However, atorvastatin, an HMG-CoA reductase inhibitor, has been reported to exhibit distinct effects on senescent phenotypes. Whether atorvastatin can induce adipose tissue senescence and the mechanisms involved are unknown. …”
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    Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes Ferroptosis-Related Senescence in Adipose Tissue
  18. 2678
    “…Increased reactive oxygen species (ROS) are upstream triggers of the senescence program. The senescence-associated secretory phenotypes (SASPs), containing interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-β1 (TGF-β1), can further exacerbate the progression of senescence. …”
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    Yiqi Huayu decoction alleviates bleomycin-induced pulmonary fibrosis in rats by inhibiting senescence
  19. 2679
    “…While overall immunity suffers from age-related deterioration (immune senescence), the different components of the immune response appear to age differently. …”
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    Senescence of the immune defences and reproductive trade-offs in females of the mealworm beetle, Tenebrio molitor
  20. 2680
    “…As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. …”
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    Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
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