“…The observation of senescence-like features led to the investigation of a drug-initiated phenotype switch. …”
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“…Cellular senescence has proved to be a strong contributor to ageing and age-related diseases, such as cancer and atherosclerosis. …”
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“…We utilized a co-culture system consisting of senescent or non-senescent macrophages directly cultured with fibroblasts, and infected with SARS-CoV-2. …”
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“…In cell cultures, in addition to myoblast proliferation and myotube differentiation, senescence induction into differentiated myotubes is also promising. …”
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“…BACKGROUND: Senescence is thought to be an imperative effect on the development of cancer. …”
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“…There are no circulating markers exclusive to cell senescence for clinical trials in middle-aged/older adults. …”
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“…Cellular senescence, a hallmark of aging, is defined as irreversible cell cycle arrest in response to various stimuli. …”
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“…Stabilized p53 increased the cell cycle inhibitor p21, resulting in cell cycle arrest and increasing the cellular senescence marker beta-galactosidase (GLB-1). RPTECs under high glucose acquired a senescence-associated secretory phenotype, which was detected by the production of IL-1β, IL-8, and TGF-β1. …”
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“…The half-maximal inhibitory concentration was determined to be 1.315 μM and the selectivity index of pterostilbene was calculated as 26.73. Moreover, cell senescence induced by HCMV infection was suppressed by pterostilbene supplementation, as shown by a decline in senescence-associated β-galactosidase activity, decreased production of reactive oxygen species and reduced expression of p16, p21 and p53, which are considered biomarkers of cellular senescence. …”
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“…A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. …”
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“…Testosterone is synthesized and secreted by Leydig cells (LCs), and the serum testosterone level decreases after aging due to the LCs senescence. However, the effect of LIPUS on human senescent LCs has not been reported. …”
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“…We observe that survivors undergo cycles of senescence, in a similar manner to non-survivors following telomerase loss, which we refer to as survivor associated senescence (SAS). …”
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“…We hypothesized that senescent cells increase following treatment with certain HIV therapies. …”
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“…However, the role of autophagy in senescence has both a “dark” and a “bright” side. This review is an attempt to reveal the mechanistic aspects of this dual role. …”
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“…We first analyzed 274 cellular senescence-associated genes by the NMF algorithm and identified two cellular senescence-associated clusters. …”
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“…However, the association between cellular senescence, caused by reduced autophagy, and atherosclerosis remains unclear. …”
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“…This study demonstrated that there is a nonlinear relationship between chronological age with HGS from infancy to senescence. Furthermore, the proposed percentiles can serve as a guide to assess and monitor upper extremity muscle strength levels at all stages of life.…”
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“…Meanwhile, DEN inhibited senescence-associated secretory phenotype (SASP) factors expression and senescence phenotype in IL-1β-treated chondrocytes. …”
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“…Recently, stress-induced senescent cells have been reported to be involved in various inflammatory diseases. …”
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“…As both RT and CDK4/6 inhibitors elicit cellular senescence, we hypothesized that a differential accumulation of senescent cells in the tumor microenvironment could explain such an observation, i.e., the inferiority of CDK4/6 inhibition with palbociclib (P) followed by RT (P→RT) as compared to RT followed by palbociclib (RT→P). …”
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