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2701“…METHODS: Grouping experiment, Normal control (NC) group: conventional culture with complete medium; Senescence group: MSCs were cultured for 48 h with complete medium containing 10 g/L d-gal; HSYA group: on the basis of senescence induction, HSYA with the suitable concentration was used to protect MSCs. …”
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2702por Badaro-Garcia, Stephanie, Hohmann, Miriam S., Coelho, Ana Lucia, Verri, Waldiceu A., Hogaboam, Cory M.“…Nintedanib increased caspase-3 activity in the presence of Fas Ligand in normal but not in IPF senescent fibroblasts. Conversely, nintedanib enhanced B cell lymphoma 2 expression in senescent IPF lung fibroblasts. …”
Publicado 2023
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2703“…BACKGROUND: Doctors have always been overwhelmed by tumor drug resistance because it is a major challenge in the clinical treatment of tumors. Cellular senescence has a strong relationship with the development of tumor drug resistance. …”
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2704por Boulet, Nathalie, Briot, Anaïs, Jargaud, Valentin, Estève, David, Rémaury, Anne, Belles, Chloé, Viana, Pénélope, Fontaine, Jessica, Murphy, Lucie, Déon, Catherine, Guillemot, Marie, Pech, Catherine, Veeranagouda, Yaligara, Didier, Michel, Decaunes, Pauline, Mouisel, Etienne, Carpéné, Christian, Iacovoni, Jason S., Zakaroff‐Girard, Alexia, Grolleau, Jean‐Louis, Galitzky, Jean, Ledoux, Séverine, Guillemot, Jean‐Claude, Bouloumié, Anne“…We have found distinct profiles of senescent progenitors based on AT location between stroma from visceral versus subcutaneous AT. …”
Publicado 2023
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2705“…BACKGROUND: This study aimed to investigate the potential mechanism of YAP1 in the senescence and degeneration of endplate chondrocytes induced by intermittent cyclic mechanical tension (ICMT). …”
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2706“…In this perspective, we hypothesize that aging first drives AD pathology burden, whereafter AD pathology putatively induces glial senescence in LOAD. We hypothesize that increasing glial senescence, particularly local senescent microglia accumulation, sustains and drives perpetuating buildup and spread of AD pathologies, glial aging, and further senescence. …”
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2707por Chin, Chiahsuan, Ravichandran, Ranjithkumar, Sanborn, Kristina, Fleming, Timothy, Wheatcroft, Stephen B., Kearney, Mark T., Tokman, Sofya, Walia, Rajat, Smith, Michael A., Flint, David J., Mohanakumar, Thalachallour, Bremner, Ross M., Sureshbabu, Angara“…Accumulation of senescent cells contributes to age-related diseases including idiopathic pulmonary fibrosis (IPF). …”
Publicado 2023
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2708“…We particularly emphasize the roles and observations of cellular senescence in neurodegenerative diseases. Finally, we discuss the observations for heavy metals inducing cellular senescence. …”
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2709“…METHODS: The stress‐induced premature senescence (SIPS) model was constructed via repeated treatment of MDFs with UVB. …”
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2710por Frei, E. R., Gossner, M. M., Vitasse, Y., Queloz, V., Dubach, V., Gessler, A., Ginzler, C., Hagedorn, F., Meusburger, K., Moor, M., Samblás Vives, E., Rigling, A., Uitentuis, I., von Arx, G., Wohlgemuth, T.“…During the particularly severe hot summer drought in 2018, widespread premature leaf senescence was observed in several broadleaved tree species in Central Europe, particularly in European beech (Fagus sylvatica L.). …”
Publicado 2022
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2711por De Rosa, Mariarosaria, Barnes, Ryan P., Nyalapatla, Prasanth R., Wipf, Peter, Opresko, Patricia L.“…Here, we show OGG1 loss or inhibition, or MUTYH loss, partially rescues telomeric 8oxoG-induced senescence, and loss of both glycosylases results in a near complete rescue. …”
Publicado 2023
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2712“…Its potential pathogenic genes and effective treatment methods are still unclear. Cell senescence has been confirmed in mental diseases. A link exists between cellular senescence and immunity, and immune-related problems affect suicide rates in individuals suffering from schizophrenia. …”
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2713por Guo, Shaolei, Ma, Ruijuan, Xu, Jianlan, Zhang, Binbin, Yu, Mingliang, Gao, Zhihong“…Thus, peach fruit softening and senescence after harvest urgently need to be addressed. …”
Publicado 2023
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2714“…The cdc13-2 allele disrupts telomerase association with telomeres, resulting in progressive telomere shortening and replicative senescence. The Mec1/ATR kinase is both a positive and a negative regulator of telomerase activity and is required for the cell cycle arrest in telomerase-deficient senescent cells. …”
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2715“…We retrieved data on cellular senescence-related genes (CSRGs) from the “CellAge” Database. …”
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2716por Angela De Stefano, Maria, Porcelli, Tommaso, Ambrosio, Raffaele, Luongo, Cristina, Raia, Maddalena, Schlumberger, Martin, Salvatore, Domenico“…D2 inhibition is associated with G1 growth arrest and induction of cell senescence, together with reduced cell migration and invasive potential. …”
Publicado 2023
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2717por Pala, Renzo, Cruciani, Sara, Manca, Alessia, Garroni, Giuseppe, EL Faqir, Mohammed Amine, Lentini, Veronica, Capobianco, Giampiero, Pantaleo, Antonella, Maioli, Margherita“…Here, we analyzed molecular programs of stemness (Oct-4; SOX2; Nanog), cell senescence, p19, p21 (WAF1/CIP1), p53, and stress response in WJ-MSCs exposed to microgravity. …”
Publicado 2023
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2718por Fettucciari, Katia, Fruganti, Alessandro, Stracci, Fabrizio, Spaterna, Andrea, Marconi, Pierfrancesco, Bassotti, Gabrio“…The ability of C. difficile toxin B to induce senescent cells and the direct correlation between CDI, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD) could cause an accumulation of senescent cells with important functional consequences. …”
Publicado 2023
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2719por Yan, Jia, Zhang, Ming Yang, Lin, Jing, Li, Ke Xin, Zhao, Zhi Min, Gao, Yu Min, Deng, Xiu Ling, Wang, Chang Shan, Wang, Hai Sheng“…Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. …”
Publicado 2023
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2720por Thamarath, Smitha Surendran, Tee, Ching Ann, Neo, Shu Hui, Yang, Dahou, Othman, Rashidah, Boyer, Laurie A, Han, Jongyoon“…Detection of cellular senescence is important quality analytics of cell therapy products, including mesenchymal stromal cells (MSCs). …”
Publicado 2023
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