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  1. 2741
    “…Cellular senescence contributes importantly to aging and aging-related diseases, including idiopathic pulmonary fibrosis (IPF). …”
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    PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells
  2. 2742
    “…Interestingly, the exo84c mutant showed a prolonged effective pollination period with higher seed sets, possibly because of the delayed stigmatic senescence when Exo84c regulated autophagy is blocked. …”
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    Exo84c interacts with VAP27 to regulate exocytotic compartment degradation and stigma senescence
  3. 2743
    “…These sex DEGs identified at old age were primarily female-biased and enriched in senescent and disease-associated microglial signatures. …”
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    Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease
  4. 2744
    “…Leaf samples of Q. mongolica were collected when they were still green (at maturity) (stage 1), during early senescence (stage 2), and during late senescence (stage 3). …”
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    Integrated physiological and metabolomic analyses reveal changes during the natural senescence of Quercus mongolica leaves
  5. 2745
    “…METHODS: Herein, we constructed 55 gastric organoids from 35 individuals, serially passaged the organoids, and captured microscopic images for phenotypic evaluation. Senescence-associated β-galactosidase (SA-β-Gal), cell diameter in suspension, and gene expression reflecting cell cycle regulation were examined. …”
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    A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids
  6. 2746
    “…Finally, we demonstrate that overexpressing MC1 delays senescence and this phenotype is dependent on the presence of the 360 loop and an intact catalytic domain. …”
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    Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence
  7. 2747
    “…Although nucleus pulposus (NP) cell senescence is a major contributor to IDD, the underlying mechanisms remain unclear. …”
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    TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration
  8. 2748
    “…There is an urgent need to discover new compounds that can boost MSCs’ stemness and delay senescence. Therefore, this study aimed to investigate the impact of walnut kernel oil (WKO) and defatted (WKD) extracts on bone marrow (BM)-MSC stemness and senescence. …”
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    Walnut Kernel Oil and Defatted Extracts Enhance Mesenchymal Stem Cell Stemness and Delay Senescence
  9. 2749
    “…BACKGROUND: Senescence have emerged as potential factors of lung cancer risk based on findings from many studies. …”
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    Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method
  10. 2750
    “…The most apparent “zinc ion transport” BP was stronger than that of normal senescence, possibly due to Zn-deficient leaves mobilizing large amounts of BP related to lipid metabolism during senescence. …”
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    ZIP Genes Are Involved in the Retransfer of Zinc Ions during the Senescence of Zinc-Deficient Rice Leaves
  11. 2751
    “…We revealed that the expression of the mutant HRAS(G12V) leads to EnSC senescence. We experimentally confirmed the inability of HRAS(G12V)-expressing EnSCs to bypass senescence and resume proliferation, even upon estrogen stimulation. …”
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    Oncogene-Induced Senescence Is a Crucial Antitumor Defense Mechanism of Human Endometrial Stromal Cells
  12. 2752
    “…NF-κB p65 expression was high in the AC group but was strongly suppressed in the AE group. We induced senescence in cultured human gingival fibroblasts using H(2)O(2) and lipopolysaccharide before erythritol treatment, which reduced elevated senescence-related marker (p16, p21, SA-β-gal, IL-1β, and TNFα) expression levels. …”
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    Erythritol Can Inhibit the Expression of Senescence Molecules in Mouse Gingival Tissues and Human Gingival Fibroblasts
  13. 2753
    “…PURPOSE: Wet AMD (wAMD) is associated with cellular senescence. However, senescent cell–targeted therapies for wAMD have rarely been comprehensively studied. …”
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    Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid
  14. 2754
    “…The concept of reversibility of cellular senescence is critical as is the timing to take actions against this “dormant” senescent state. …”
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    Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes
  15. 2755
    “…BACKGROUND: Cellular senescence is an age-related physiological process that contributes to tissue dysfunction and accelerated onset of chronic metabolic diseases including hypertension. …”
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    Tissue-specific expression of senescence biomarkers in spontaneously hypertensive rats: evidence of premature aging in hypertension
  16. 2756
    “…Further analysis demonstrated differential nucleosomal occupancies in self-renewal and senescence-related genes for pMSCs grown in XM and FM, respectively. …”
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    Regulation of self-renewal and senescence in primitive mesenchymal stem cells by Wnt and TGFβ signaling
  17. 2757
    “…This study examined the effects of different storage temperatures on leaf senescence, nitrogen assimilation, and remobilization in Pak Choi (Brassica rapa subsp. chinensis). …”
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    Effects of Storage Temperatures on Nitrogen Assimilation and Remobilization during Post-Harvest Senescence of Pak Choi
  18. 2758
    “…Poplar leaf development occurs in stages, from young to mature and then from mature to senescent; these are accompanied by various phenotypic and physiological changes. …”
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    Spatiotemporal miRNA and transcriptomic network dynamically regulate the developmental and senescence processes of poplar leaves
  19. 2759
    “…In conclusion, this study revealed that summer leaf senescence is delayed in herbaceous peony through shading and growth regulators. …”
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    Effects of slight shading in summer on the leaf senescence and endogenous hormone and polyamine contents in herbaceous peony
  20. 2760
    por Shen, Cheng
    Publicado 2023
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    ID1 and IGFBP3: roles in cellular senescence, cardiac development, angiogenesis and cancer diagnosis
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