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“…Cellular senescence (CS) is increasingly implicated in the etiology of age-related diseases. …”
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“…Cellular senescence is a phenomenon by which oncogene-activated, stressed or damaged cells undergo a stable cell cycle arrest. …”
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“…A growing number of studies have convincingly demonstrated a paradoxical role for spontaneous senescence and therapy-induced senescence (TIS), that senescence may involve both cancer prevention and cancer aggressiveness. …”
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“…Chronic latent CMV infection was associated with increased senescent CD8(+) lymphocytes in healthy controls, but this shift was less apparent in PD patients. …”
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“…Senescence reduced both basal TR and TR stimulated by aminoglycosides. …”
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“…Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. …”
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“…Many databases have shown MSC-based treatment can be beneficial in the reduction of osteogenesis induced by senescence. In this article, we will discuss the potential effect of MSCs in senescence cells related to osteogenesis.…”
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“…Nonetheless, although accumulated evidence supports the role of cellular senescence in aging and AD, the mechanisms that promote cell senescence and how senescent cells contribute to AD neuropathophysiology remain largely unknown. …”
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“…In particular, several senescence inducers including telomere shortening, mitochondrial dysfunction, and oxidative stress and senescence biomarkers such as cell cycle inhibitors, senescence-associated secretory phenotype, chromatin reorganization, and microRNA have been implicated in DM pathogenesis. …”
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“…Ageing, death, and potential immortality lie at the heart of biology, but two seemingly incompatible paradigms coexist in different research communities and have done since the nineteenth century. The universal senescence paradigm sees senescence as inevitable in all cells. …”
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“…Our review reveals important mechanisms of organelle interactions in cellular senescence and provides important clues for intervention strategies from a new perspective.…”
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“…Although the role of senescence in many physiological and pathological processes is becoming more identifiable, many aspects of senescence are still enigmatic. …”
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“…Cellular senescence is a potent tumor suppressor mechanism. However, the untoward effect is that the accumulation of senescent cells promotes loss of resilience, aging and age-related diseases. …”
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“…In plants senescence is the final stage of plant growth and development that ultimately leads to death. …”
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“…Stress-induced premature senescence can contribute to the accelerated metabolic aging process in diabetes. …”
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“…Indeed, Lamin B1, a key NE protein that is consistently downregulated in senescence, has become a marker for senescence. Other NE proteins have also been shown to play a role in senescence, including LINC (linker of nucleoskeleton and cytoskeleton) complex proteins. …”
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