“…Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85α, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrophy. …”
Enlace del recurso
Enlace del recurso

“…Collectively, these results suggest that the altered nuclear staining of methylated TRF2 may represent ATM-mediated nuclear structural alteration associated with cellular senescence. Our data further imply that methylated TRF2 can serve as a potential biomarker for cellular senescence.…”
Enlace del recurso
Enlace del recurso

“…Senescence-inducing stimuli are myriad and, recently, we and others have demonstrated the role exerted by microRNAs in the induction and maintenance of senescence, by the identification of a subset of Senescence-Associated microRNAs (SAmiRs) up-regulated during replicative or stress-induced senescence and able to induce a premature senescent phenotype when over-expressed in human primary cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular senescence is a crucial tumor suppressor mechanism. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sequential and monocarpic senescence are observed at vegetative and reproductive stages, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we show that transgenic expression of miR-17 extends lifespan and inhibits cellular senescence. We propose that miR-17 acts as a critical regulator of cellular senescence and tumorigenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PUVA-treated fibroblasts grown in the presence of Octa are partially but significantly rescued from the features of the cellular senescence-like phenotype, such as cytoplasmic enlargement, the expression of senescence-associated-β-galactosidase, matrix-metalloproteinase-1, and cell cycle proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Doxorubicin-induced DDR followed by cell senescence could only be observed in L5 and S4 cells, but not in the S3R ones. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The senescence-accelerated mouse (SAM) was developed by selective breeding of the AKR/J strain, based on a graded score for senescence, which led to the development of both senescence-accelerated prone (SAMP), and senescence-accelerated resistant (SAMR) strains. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Oncogene-induced senescence (OIS) is a robust and sustained antiproliferative response to oncogenic stress and constitutes an efficient barrier to tumour progression. …”
Enlace del recurso
Enlace del recurso

“…Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This is due to repressed expression of p16(INK4a), which, in turn, delays MaSC senescence. Together, our studies support a model in which SLITs restrict the expansion of MaSCs by countering the activity of WNTs and limiting self-renewal.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We hypothesized that lymphocyte senescence and increased Pgp1 are also associated with down-regulation of the GC receptor (GCR). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: During wheat senescence, leaf components are degraded in a coordinated manner, releasing amino acids and micronutrients which are subsequently transported to the developing grain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Taken together, we can report that loss of Tnmd affects significantly the self-renewal and senescence properties, but not the multipotential of TSPC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Primary cells enter replicative senescence after a limited number of cell divisions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: PubMed searches were conducted using separate terms to retrieve articles on (1) the role of microRNAs on aging and tissue degeneration, (2) specific microRNAs that influence cellular and organism senescence, (3) microRNAs in age-related musculoskeletal conditions, and (4) the diagnostic and therapeutic potential of microRNAs in age-related musculoskeletal conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These novel findings would point to a deleterious role of oxidatively modified molecules in early cell senescence of T21F, thereby linking replicative and stress-induced senescence in cultured cells to premature aging in DS.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here for the first time, we report that in addition to apoptosis, rWmhsp60 antigen in filarial pathogenesis also induces molecular senescence in monocytes. Targeting TLR-4, therefore, presents a promising candidate for treating rWmhsp60-induced apoptosis and senescence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso