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  1. 2841
    “…We examined the effect of senescent cells on erectile function after injection of senescent cells into the penises of mice. …”
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    Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice
  2. 2842
    “…We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. …”
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    In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
  3. 2843
    “…Our findings demonstrate that TRF2 is a specific target of miR-23a, and uncover a previously unknown role for miR-23a in telomere regulation and cellular senescence.…”
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    Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression
  4. 2844
    “…Hyperglycemia was reported to cause bone marrow hematopoietic niche dysfunction, and high glucose (HG) in the cultured medium induces MSC senescence. The underlying mechanism is unclear. Here, we investigated the role of HG-induced autophagy in bone-marrow-derived mesenchymal stem cell (BMSC) senescence. …”
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    High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy
  5. 2845
    “…Decreased Myc expression was observed and atrophy of the adult SDS pancreas could be explained by the senescence of acinar cells, characterized by induction of Tgfβ, p15(Ink4b) and components of the senescence-associated secretory program. …”
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    In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency
  6. 2846
    “…The main outcome of low radiation exposure, besides reduction of cell cycling, is the triggering of senescence, while the contribution to apoptosis is minimal. …”
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    Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process
  7. 2847
    “…Several animal species are considered to exhibit what is called negligible senescence, i.e. they do not show signs of functional decline or any increase of mortality with age. …”
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    Stability analysis of a model gene network links aging, stress resistance, and negligible senescence
  8. 2848
    “…Consequently, targeting senescent cells offers the potential of being a promising therapeutic approach.…”
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    Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients
  9. 2849
    “…However, the characterizaton of PAO during leaf senescence induced by environmental factors is not well understood. …”
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    Cloning and characterization of the pepper CaPAO gene for defense responses to salt-induced leaf senescence
  10. 2850
    “…We have shown that COPD patients have increased steroid resistant CD28null (senescent) pro-inflammatory T and NKT-like peripheral blood cells (particularly CD8+ subsets) and we hypothesized that these changes would be associated with a loss of HDAC2 from these senescent pro-inflammatory lymphocytes. …”
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    Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes
  11. 2851
    “…Phorbol myristate acetate (PMA), as a potent tumor promoter, may induce microglial senescence. The present study investigated the effect of PMA infection on microglial senescence. …”
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    Repeated intra-nigrostriatal injection of phorbol myristate acetate induces microglial senescence in adult rats
  12. 2852
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    Cellular Senescence and Inflammatory Burden as Determinants of Mortality in Elderly People Until the Extreme old age
  13. 2853
    “…Sarcopenia is an age-related systemic syndrome with progressive deterioration in skeletal muscle functions and loss in mass. Although the senescence-accelerated mouse P8 (SAMP8) was reported valid for muscular ageing research, there was no report on the details such as sarcopenia onset time. …”
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    Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)
  14. 2854
    “…Insulin signaling, which regulates important functions of ECs, is impaired in senescent and aged ECs. Actually, by down-regulating GM1 on senescent ECs and overloading exogenous GM1 onto non-senescent ECs, we showed that an increased abundance of GM1 functionally contributes to the impairment of insulin signaling in ECs. …”
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    Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells
  15. 2855
    “…Introduction. Senescence of peritoneal mesothelial cells represents a biological program defined by arrested cell growth and altered cell secretory phenotype with potential impact in peritoneal dialysis. …”
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    Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells
  16. 2856
    “…Thus, aging‐induced infection susceptibility and immune senescence are replicated in accelerated aging Lmna (Dhe) mice.…”
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    Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna (Dhe) mice
  17. 2857
    “…The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. …”
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    Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo
  18. 2858
    “…Interestingly, the inactivation of p53 after senescence resulted in reentry into the cell cycle and rapid tumor progression. …”
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    p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells
  19. 2859
    “…The main characteristic of senescence is its stability which relies on the persistence of DNA damage. …”
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    Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
  20. 2860
    “…Senescent cells secrete several molecules that help to prevent the progression of cancer. …”
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    Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
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