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2921por He, Xiaoyuan, Yang, Aimin, McDonald, Daniel G., Riemer, Ellen C., Vanek, Kenneth N., Schulte, Bradley A., Wang, Gavin Y.“…However, the role of miR-34a in ionizing radiation (IR)-induced senescence in NSCLC cells remains poorly understood. …”
Publicado 2017
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2922“…At their proliferative limit, normal cells arrest and undergo replicative senescence, displaying large cell size, flat morphology, and senescence-associated beta-galactosidase (SA-β-Gal) activity. …”
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2923por Ding, Yanxia, Zheng, Yuan, Liu, Tao, Chen, Ting, Wang, Changhua, Sun, Qiushuang, Hua, Mutian, Hua, Tianmiao“…Here, we compared the neuronal response properties and markers of GABAergic inhibition in the primary visual cortex (V1) of young adult and senescent rats. Compared with those of young adult rats, old rats’ V1 neurons exhibited significantly increased visually evoked responses and spontaneous activity, a decreased signal-to-noise ratio and reduced response selectivity for the stimulus orientation and motion direction. …”
Publicado 2017
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2924por Otgaar, Tyrone C., Ferreira, Eloise, Malindisa, Sibusiso, Bernert, Martin, Letsolo, Boitelo T., Weiss, Stefan F.T.“…Here we show that overexpression of LRP::FLAG resulted in significantly elevated hTERT levels, telomerase activity and telomere length, respectively, with concomitantly reduced levels of senescence markers. These data suggest a novel function of LRP/LR hampering the onset of senescence through elevating hTERT levels and telomerase activity, respectively. …”
Publicado 2017
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2925por Hall, Hana, Medina, Patrick, Cooper, Daphne A., Escobedo, Spencer E., Rounds, Jeremiah, Brennan, Kaelan J., Vincent, Christopher, Miura, Pedro, Doerge, Rebecca, Weake, Vikki M.“…Here, we sought to identify gene expression changes and the genomic features of differentially regulated genes in photoreceptors that contribute to visual senescence. RESULTS: To identify gene expression changes that could lead to visual senescence, we characterized the aging transcriptome of Drosophila sensory neurons highly enriched for photoreceptors. …”
Publicado 2017
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2926“…Calcitriol also induced cell apoptosis and senescence of 786-O and ACHN (P<0.05). Calcitriol can increase the expression of histone demethylase JMJD3 and cell senescence marker p16INK4A (P<0.05). …”
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2927“…Here we studied UVA-induced senescence in human fibroblasts in vitro. It is known that senescence occurs, when cell cycle is arrested, but mTOR is still active, thus converting arrest to senescence (geroconversion). …”
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2929“…More interestingly, Gbp1 Kd macrophages undergo senescence as evidenced by increased activation of AMPK-p53 pathway and positive staining of β-galactosidase. …”
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2930por He, Li, Wu, Wenwu, Zinta, Gaurav, Yang, Lan, Wang, Dong, Liu, Renyi, Zhang, Huiming, Zheng, Zhimin, Huang, Huan, Zhang, Qingzhu, Zhu, Jian-Kang“…We classify NMR19 as NMR19-4 and NMR19-16 based on its location, and uncover NMR19-4 as an epiallele that controls leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH). …”
Publicado 2018
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2931“…The results showed that bleomycin induced cellular senescence in AFSCs as evidenced by senescence-associated secretory phenotype. …”
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2932por Wang, Jing, Feng, Yiji, Han, Peng, Wang, Fenghua, Luo, Xueting, Liang, Jian, Sun, Xiangjun, Ye, Jing, Lu, Yiming, Sun, Xiaodong“…Telomerase overexpression rescued A2E-mediated RPE cell senescence, indicating that telomere dysfunction plays an important role in A2E-based senescence. …”
Publicado 2018
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2933“…Compared with the dynamic compression, static compression significantly promoted disc NP cell senescence, reflected by the increased senescence-associated β-galactosidase (SA-β-Gal) activity, senescence-associated heterochromatic foci (SAHF) formation and senescence markers expression, and the decreased telomerase (TE) activity and NP matrix biosynthesis. …”
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2934“…Cellular senescence is a damage response aimed to orchestrate tissue repair. …”
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2935“…Leaf senescence is an important agronomic trait that affects both crop yield and quality. …”
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2936por Liang, Dong, Shen, Yanqiu, Ni, Zhiyou, Wang, Qin, Lei, Zhi, Xu, Nengqin, Deng, Qunxian, Lin, Lijin, Wang, Jin, Lv, Xiulan, Xia, Hui“…All of these results can provide clear proof that melatonin plays a key roles in delaying leaf senescence.…”
Publicado 2018
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2937por Haddad, Cylia, Arkoun, Mustapha, Jamois, Franck, Schwarzenberg, Adrian, Yvin, Jean-Claude, Etienne, Philippe, Laîné, Philippe“…The aim of this work was to study the effect of a short Si supply duration (7 days) on growth, N uptake, photosynthetic activity, and leaf senescence progression in rapeseed subjected (or not) to N starvation. …”
Publicado 2018
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2938por Hou, Xue-Qin, Song, Hou-Pan, Chen, Yun-Bo, Cheng, Shu-Yi, Fang, Shu-Huan, Zhang, Ji-Guo, Wang, Qi“…The present study aimed to investigate the possible effects and underlying molecular mechanism of Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine, on age-related degeneration of brain physiology in senescence-accelerated mouse prone 8 (SAMP8) mice. SAMP8 mice (age, 6 months) were administered BSYZ (1.46, 2.92 and 5.84 g/kg/day) for 30 days. …”
Publicado 2018
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2939por Li, Li, van Breugel, Pieter C, Loayza-Puch, Fabricio, Ugalde, Alejandro Pineiro, Korkmaz, Gozde, Messika-Gold, Naama, Han, Ruiqi, Lopes, Rui, Barbera, Eric P, Teunissen, Hans, de Wit, Elzo, Soares, Ricardo J, Nielsen, Boye S, Holmstrøm, Kim, Martínez-Herrera, Dannys J, Huarte, Maite, Louloupi, Annita, Drost, Jarno, Elkon, Ran, Agami, Reuven“…Here, we first identified lncRNAs that were differentially expressed between senescent and non-senescent human fibroblast cells. …”
Publicado 2018
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2940por Kim, Hyun-Kyung, Kang, Mi Ae, Kim, Mi-Sook, Shin, Young-Joo, Chi, Sung-Gil, Jeong, Jae-Hoon“…Recently, the HMGB2 gene was found to be significantly downregulated during senescence and shown to regulate the expression of senescent-associated secretory proteins. …”
Publicado 2018
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