“…Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. …”
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“…Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. …”
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“…Here, we describe general triggers and characteristics of senescence. In addition, we describe the influence of senescent cells in ageing and different age-related diseases.…”
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“…The involvement of stress-induced specialized metabolites in senescence and nutrient response pathways is also discussed.…”
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“…Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. …”
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“…Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory, pro-inflammatory phenotype. …”
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“…Cellular senescence plays a paradoxical role in tumorigenesis through the expression of diverse senescence-associated (SA) secretory phenotypes (SASPs). …”
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“…In this review, we discuss the role of basal autophagy in maintaining homeostasis, in part through the maintenance of stem cell populations and the prevention of cellular senescence. We also consider how stress‐induced senescence, for example, during oncogene activation and in premalignant disease, might rely on autophagy, and the possibility that the age‐associated decline in autophagy might promote tumour development through a variety of mechanisms. …”
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“…Senescent cells are cleared in part by the immune system, a process that is diminished in obesity and aging, likely due in part to senescence of immune cells themselves. …”
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“…In addition, LPS enhances the inflammatory properties (senescence-associated secretory phenotype [SASP]) of senescent endothelial cells. …”
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“…Cellular senescence is characterized by irreversible cell cycle arrest in response to different triggers and an inflammatory secretome. …”
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“…As a result of IR injury, senescent cells can accumulate in multiple organs. …”
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“…The occurrence of chronic senescence is inseparable from senescence-associated secretory phenotype (SASP) and senescence-related pathways. …”
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“…Recently, it has been discovered that the senescent cells accumulate in the alveolar bone and promote a senescence-associated secretory phenotype (SASP). …”
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“…This review aims to emphasize the features of immunosenescence and its influence on kidney diseases and immunotherapy, highlighting the future directions of kidney disease treatment using senescence-focused techniques.…”
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