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  1. 3001
    “…Declines in survival and performance with advancing age (senescence) have been widely documented in natural populations, but whether patterns of senescence across traits reflect a common underlying process of biological ageing remains unclear. …”
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    Comparing individual and population measures of senescence across 10 years in a wild insect population
  2. 3002
    “…Cell cycle arrest in SETD1A knockdown senescent cells is independent of mutations in p53, RB and p16, known senescence mediators; instead, it is sustained through transcriptional suppression of SKP2, which degrades p27 and p21. …”
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    SETD1A protects from senescence through regulation of the mitotic gene expression program
  3. 3003
    “…Stem cells undergo senescence both in vivo, contributing to the progressive decline in self-healing mechanisms, and in vitro during prolonged expansion. …”
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    Early Developmental Zebrafish Embryo Extract to Modulate Senescence in Multisource Human Mesenchymal Stem Cells
  4. 3004
    “…Furthermore, HMGB1 upregulated Caveolin-1, which also was related RPE cell senescence. To investigate whether changes in HMGB1 and Caveolin-1 expression under A2E exposure contribute to RPE cell senescence, human ARPE-19 cells were stimulated with A2E; expression of HMGB1, Caveolin-1, tight junction proteins and senescent phenotypes were verified. …”
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    HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration
  5. 3005
    “…Lamin-B1 may serve as a tissue-based biomarker for new therapeutic agents targeting therapy-induced senescence.…”
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    Lamin-B1 is a senescence-associated biomarker in clear-cell renal cell carcinoma
  6. 3006
    “…Hundreds of senescence‐associated genes were identified in leaves and stems. …”
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    Nitrogen remobilization and conservation, and underlying senescence‐associated gene expression in the perennial switchgrass Panicum virgatum
  7. 3007
    “…These results demonstrate that DHA might inhibit HepG2.2.15 cells proliferation through inducing cellular senescence and autophagy.…”
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    Dihydroartemisinin inhibits HepG2.2.15 proliferation by inducing cellular senescence and autophagy
  8. 3008
    “…Senescence is transmitted to non-intoxicated bystander cells by an unidentified senescence-associated secreted factor that enhances Salmonella infections. …”
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    Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
  9. 3009
    “…Intracellular calcium (Ca(2+)(i)) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are critical factors that contribute to senescence-related processes. Ceramides, a pleiotropic class of sphingolipids, are important mediators of cellular senescence, but their role in neuronal aging is still largely unexplored. …”
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    Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence
  10. 3010
    “…Similarly, staining for senescence-associated beta galactosidase (SABG) and qPCR for gene expression of senescence markers, p16 and p21, as well as senescence-associated secretory phenotype (SASP) components, IL-6, IL-8, MCP-1, and PAI-1, were studied before and after treatment with dasatinib and compared between PE and NP. …”
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    Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
  11. 3011
    “…Here, we demonstrated the critical role of C/EBPα in podocyte senescence and kidney aging by generating a genetically modified mouse model of chronological aging in which C/EBPα was selectively deleted in podocytes and by overexpressing C/EBPα in cultured podocytes, in which premature senescence was induced by treatment with adriamycin. …”
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    C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice
  12. 3012
    “…The aim of the present study is to explore the potential anti-dementia effects of Mangiferin in a senescence-accelerated mouse prone 8 (SAMP8) mouse model. …”
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    Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model
  13. 3013
    “…The present study demonstrated that treatment with TGF-β1 induced PDLSC senescence, characterized by increases in senescence-associated beta-galactosidase activity and elevation of both p16 and p21 expression. …”
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    TGF-β induces periodontal ligament stem cell senescence through increase of ROS production
  14. 3014
    “…Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). …”
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    mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
  15. 3015
    “…Here we isolate and culture connective tissue fibroblasts from highly regenerative mammals (Acomys and Oryctolagus) to determine how these cells interpret signals that normally induce cellular senescence in non-regenerating mammals (Mus and Rattus). …”
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    Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
  16. 3016
    “…The molecular mechanism study on ptsd1 showed that the senescence-associated genes (SAGs) were highly expressed, and spike differentiation related homeotic genes were depressed. …”
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    Enhanced Senescence Process is the Major Factor Stopping Spike Differentiation of Wheat Mutant ptsd1
  17. 3017
    “…The senescence of vascular endothelial cells (ECs) plays a critical role in aging-related cardiovascular diseases. …”
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    Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging-related coronary atherosclerosis
  18. 3018
    “…The mechanisms underlying the role of alveolar epithelial cell (AEC) senescence in IPF remain poorly understood. We aimed to investigate if PTEN/Akt activates AEC senescence to induce pulmonary fibrosis. …”
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    PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation
  19. 3019
    “…We found that D-galactose treatment significantly suppressed cell viability and induced cellular senescence. In addition, as of the accumulation of senescent cells, we proposed that the senescence-associated secretory phenotype (SASP) can stimulate age-related pathologies and chemoresistance in brain. …”
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    D-galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence
  20. 3020
    “…We recently reported that during the natural history of T1D in humans and the female nonobese diabetic (NOD) mouse model, beta cells acquire a senescence-associated secretory phenotype (SASP) that is a major driver of disease onset and progression, but the mechanisms that activate SASP in beta cells were not explored. …”
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    BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes
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