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  1. 3041
    “…Furthermore, TAZ knockdown induced cellular senescence in a p53-dependent manner. These results suggest that TAZ negatively regulates the tumor suppressor functions of p53 and attenuates p53-mediated cellular senescence.…”
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    Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence
  2. 3042
    “…More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.…”
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    Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
  3. 3043
    “…The gel effect on the senescence maker secretory associated-β-galactosidase (SA-β-gal) activity was measured by a histochemical staining. …”
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    3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing
  4. 3044
    “…Based on the study of a long-lasting senescence-like growth arrest (10-12 weeks) of human dermal fibroblasts induced by psoralen plus UVA (PUVA) treatment, we here revealed that slowly repaired bulky DNA damages can serve as a “molecular scar” leading to reduced cell proliferation through persistent endogenous production of reactive oxygen species (ROS) that caused accelerated telomere erosion. …”
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    Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence
  5. 3045
    “…METHODS: AAP endothelial cells were isolated and cultured in physiologic (5% O(2)) or hyperoxic condition (40% O(2)) for 14 days to induce cell senescence. miRNA and protein expression profiles of control and senescent cells were analyzed with miRNA microarray and isobaric tags for relative and absolute quantification (iTRAQ), respectively. …”
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    Cell senescence altered the miRNA expression profile in porcine angular aqueous plexus cells
  6. 3046
    “…Specifically, if immunity is worm-directed, then treatment of long-standing infections comprised of old senescent worms could enable infection with new, highly fecund worms. …”
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    Concomitant Immunity and Worm Senescence May Drive Schistosomiasis Epidemiological Patterns: An Eco-Evolutionary Perspective
  7. 3047
    “…In the skin, senescent cells have been found to markedly accumulate with age, and thus might impact directly on skin characteristics. …”
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    Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging
  8. 3048
    “…The present study investigated XDH’s role in regulating rice leaf senescence. We measured physical characteristics, chlorophyll content and fluorescence parameters, active oxygen metabolism, and purine metabolism in wild-type Kitaake rice (Oryza sativa L.), an OsXDH over-expression transgenic line (OE9), and an OsXDH RNA interference line (Ri3) during different growth stages. …”
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    Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield
  9. 3049
    “…We and others previously demonstrated that Axitinib triggers cellular senescence. In particular, Axitinib-dependent senescence of HUVECs (human umbilical vein endothelial cells) is accompanied by intracellular reactive oxygen species(ROS) increase and early ataxia telangiectasia mutated(ATM) activation. …”
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    Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model
  10. 3050
    “…Understanding the processes and factors involved in accelerated senescence and other abnormal intercellular signaling will identify new therapeutic targets and lead to improved methods of diagnosis and monitoring for patients with CKD-associated CVDs.…”
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    Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence
  11. 3051
    “…Thus, NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1.…”
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    High-affinity Na(+)-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
  12. 3052
    “…Plant senescence is a highly regulated process that allows nutrients to be mobilized from dying tissues to other organs. …”
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    Abscisic Acid and Jasmonate Metabolisms Are Jointly Regulated During Senescence in Roots and Leaves of Populus trichocarpa
  13. 3053
    “…In vivo efficacy of the RL-208, a new NMDA receptor blocker described recently, with favourable pharmacokinetic properties was evaluated in Senescence accelerated mice prone 8 (SAMP8), a mice model of late-onset AD (LOAD). …”
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    A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
  14. 3054
    “…Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. …”
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    A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
  15. 3055
    “…We found that DNAJB9 inhibits p53-dependent oncogene-induced senescence (OIS) and induces neoplastic transformation under oncogenic RAS activation in mouse primary fibroblasts. …”
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    DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation
  16. 3056
    “…They also display an enhanced stress resistance phenotype, negligible senescence and very rarely are they burdened with chronic age-related diseases. …”
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    Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation
  17. 3057
    “…CONCLUSION: Our findings suggested that miR-214 plays a role in the modulation of VSMC angiogenesis, proliferation, and senescence with its plasma level being increased in CAS patients with elevated LDL-C value, implying that it may be a vascular senescence marker and a potential therapeutic target for vascular diseases.…”
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    MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis
  18. 3058
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    Comment in Response to “Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy etc. by B. Kaina”
  19. 3059
    “…Leaf senescence is an essential physiological process that is accompanied by the remobilization of nutrients from senescent leaves to young leaves or other developing organs. …”
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    Genetic Network between Leaf Senescence and Plant Immunity: Crucial Regulatory Nodes and New Insights
  20. 3060
    “…AngII stimulation in ECs resulted in cellular senescence assessed by senescence-associated β galactosidase activity. …”
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    Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II
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