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  1. 3141
    “…Severe early and late complications with lungs can increase the risk of morbidity in cancer patients after RT. Herein, senescence of lung epithelial cells following RT-induced cellular stress, or more precisely the respective altered secretory profile, the senescence-associated secretory phenotype (SASP), was suggested as a central process for the initiation and progression of pneumonitis and pulmonary fibrosis. …”
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    Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells
  2. 3142
    “…Cerebroprotein hydrolysate‐I (CH‐I)，a mixture of peptides extracted from porcine brain tissue，has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain senescence via JAK2/STAT3 pathway. …”
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    Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice
  3. 3143
    “…The correlation between aging and cellular senescence has been established. Cellular senescence is correlated with the dysregulation of the proteolytic pathway and mitochondrial dysfunction, which are also associated with the aggregation of α-synuclein (α-syn). …”
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    LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells
  4. 3144
    “…At the basis of this aggressive phenotype, we uncover the engagement of a senescence program, characterized by DNA damage response activation and a senescence-associated secretory phenotype, which affects also non-mutated bystander cells. …”
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    Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
  5. 3145
    “…Senescent markers p21, γH2AX, and β-gal, and some senescence-associated secretory proteins (SASP) increased with aging, as shown by staining and biochemical analyses. …”
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    Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle
  6. 3146
    “…Aneuploidy is a hallmark of cancer, and we previously found that untransformed cells that had undergone senescence due to highly abnormal karyotypes are eliminated by natural killer (NK) cells in vitro. …”
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    Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells
  7. 3147
    “…Cellular senescence has been considered an important driver of many chronic lung diseases. …”
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    OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis
  8. 3148
    por Wen, Yahui, Shen, Feiyan, Wu, Haibin
    Publicado 2021
    “…Complement component 5a (C5a) and the C5a receptor (C5aR) have been reported to play a key role in the process of cellular senescence. However, to the best of our knowledge, the exact role of C5a and C5aR in cellular senescence in the heart remains largely unknown. …”
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    Role of C5a and C5aR in doxorubicin-induced cardiomyocyte senescence
  9. 3149
    “…WRKY transcription factors play essential roles during leaf senescence. However, the mechanisms by which they regulate this process remains largely unknown. …”
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    AtWRKY75 positively regulates age-triggered leaf senescence through gibberellin pathway
  10. 3150
    “…As T2DM has been reported to cause T cell senescence in both prediabetic and diabetic patients, there is a possibility that poor prognosis in EOC patients with T2DM is partly due to the accumulation of senescent T cells in the omentum. …”
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    Potential Role of Diabetes Mellitus-Associated T Cell Senescence in Epithelial Ovarian Cancer Omental Metastasis
  11. 3151
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    Expression of cellular senescence and neural stem cell markers in a case of advanced retinal fibrosis
  12. 3152
    “…Here, we show that aging OA-MSC plays an important role in cell senescence, fibrosis, and inflammation in cartilage. …”
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    Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage
  13. 3153
    “…SIMPLE SUMMARY: Recent scientific discoveries identify cell senescence as pivotal in hepatocellular cancer (HCC) biology. …”
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    Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective
  14. 3154
    por Zhu, Na, Liu, Xinran, Xu, Meihong, Li, Yong
    Publicado 2021
    “…Several lines of evidence suggest an inhibitory role of dietary nucleotides (NTs) against oxidative stress and inflammation, which promote senescence in age-associated cardiovascular diseases. …”
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    Dietary Nucleotides Retard Oxidative Stress-Induced Senescence of Human Umbilical Vein Endothelial Cells
  15. 3155
    “…The plasmonic nanoprobe-based high-spatial hyperspectral imaging provides an advanced way to study the dynamics of histone modifications for predicting the progression of diseases or senescence.…”
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    High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes
  16. 3156
    “…This process called replicative senescence is associated with genomic instability and participates in tissue and organismal ageing. …”
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    Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae
  17. 3157
    “…The senescence‐associated secretory phenotype (SASP) is a striking characteristic of senescence. …”
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    Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence
  18. 3158
    por Henson, Sian M., Aksentijevic, Dunja
    Publicado 2021
    “…Recent findings have unequivocally identified type 2 diabetes (T2D) as a chronic inflammatory disease characterized by inflammation and immune senescence. Immunosenescence is a hallmark of the prolonged low-grade systemic inflammation, in particular associated with metabolic syndrome and can be a cause as well as a consequence of T2D. …”
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    Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of Old Age?
  19. 3159
    “…Expansion of the CD28(null) senescent T-cell populations, a common phenomenon in aging and several chronic inflammatory conditions, is associated with higher morbidity and mortality rates in COVID-19. …”
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    Accumulation of CD28(null) Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients
  20. 3160
    “…Cellular senescence causes a dramatic alteration of chromatin organization and changes the gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies through the senescence-associated secretory phenotype (SASP). …”
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    Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer
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