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  1. 3161
    “…Interestingly, the loss of PPP1R15A appeared to promote lung fibroblast senescence. Taken together, our findings demonstrate the major role of PPP1R15A in the regulation of lung mesenchymal cells, and regulation of PPP1R15A may represent a novel therapeutic strategy in IPF.…”
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    Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF
  2. 3162
    “…It has been suggested that senescence might play a role, but the pathophysiological link between senescence and lesion development remains unexplained. …”
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    Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1
  3. 3163
    “…Additionally, DRG2 knockdown significantly abolished oxidative stress-induced premature senescence. Our results provide a possible molecular mechanism for investigation of cellular senescence and aging regulated by DRG2.…”
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    DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts
  4. 3164
    “…In our previous study, we found that high doses of several substances with antioxidant capacities (Tempol, resveratrol, diphenyleneiodonium) can cause genotoxic stress and induce premature senescence in the human mesenchymal stem cells (MSCs). …”
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    Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress
  5. 3165
    “…Overexpression of TFCP2 inhibited cell senescence. Knockdown of TFCP2 promoted cell senescence. …”
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    TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer
  6. 3166
    “…In in vitro experiments, knockdown of UBE2E3 accelerated cellular senescence and inhibited osteogenic differentiation of young BMSCs. …”
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    UBE2E3 regulates cellular senescence and osteogenic differentiation of BMSCs during aging
  7. 3167
    “…Our results indicate that HU inhibits the growth of human BMMSC alongside senescence-like changes in both morphology and replicative potential, provokes cell cycle arrest at the S phase without affecting cellular viability and induces the expression of senescence-associated β-galactosidase and p16INK4. …”
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    Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro
  8. 3168
    “…Escape from senescence eventually leads to hepatocellular carcinoma. …”
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    Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis
  9. 3169
    “…Legume nodule development and senescence directly affect nitrogen fixation efficiency and involve a programmed series of molecular events. …”
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    Identification of the Important Genes of Bradyrhizobium diazoefficiens 113-2 Involved in Soybean Nodule Development and Senescence
  10. 3170
    “…Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. …”
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    Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer
  11. 3171
    “…We showed that UVA induces proteome remodeling and senescence in primary keratinocytes, eliciting potent antioxidant and pro-inflammatory responses. …”
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    A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes
  12. 3172
    “…BACKGROUND: Aging and senescence can alter immune cell fitness and influence the efficacy of lung cancer treatments, especially immunotherapy. …”
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    Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma
  13. 3173
    “…METHODS: In this study, the stemness-associated senescence (SAS) phenotype of PRCC was obtained by a bioinformatics analysis. …”
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    Stemness-associated senescence genes as potential novel risk factors for papillary renal cell carcinoma
  14. 3174
    “…Advances in the in vivo detection of cellular senescence are still crucial to monitor the action of senolytic drugs and to assess the early onset or accumulation of senescent cells. …”
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    A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence
  15. 3175
    “…The senescence of lens epithelial cells (LECs) is a major factor leading to age-related cataract (ARC). …”
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    Metformin protects lens epithelial cells against senescence in a naturally aged mouse model
  16. 3176
    “…This study investigates the catechin composition and protective effect of green tea extract on senescence-mediated redox imbalance in the livers and kidneys of aged mice. …”
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    Senescence-Mediated Redox Imbalance in Liver and Kidney: Antioxidant Rejuvenating Potential of Green Tea Extract
  17. 3177
    “…Finally, we discuss the relevance of biomarkers described for senescence and aging and senolytic therapies as potentially new adjunctive strategies to reduce the burden of NTM PD.…”
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    Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease
  18. 3178
    “…We developed a chemical cocktail to induce senescence of iPSC‐derived neurons to address this challenge. …”
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    Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration
  19. 3179
    “…OBJECTIVE: Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. …”
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    Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions
  20. 3180
    “…Studies have demonstrated the antioxidant and anti-senescence effects of PCA in different cell types. However, the anti-senescence effects of PCA in nucleus pulposus (NP) cells have remained to be determined. …”
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    p-Coumaric acid suppresses reactive oxygen species-induced senescence in nucleus pulposus cells
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