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  1. 3181
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    Trehangelins ameliorate inflammation-induced skin senescence by suppressing the epidermal YAP-CCN1 axis
  2. 3182
    “…Irreparable DNA damage following ionizing radiation (IR) triggers prolonged DNA damage response and induces premature senescence. Cellular senescence is a permanent state of cell-cycle arrest characterized by chromatin restructuring, altered nuclear morphology and acquisition of secretory phenotype, which contributes to senescence-related inflammation. …”
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    Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy
  3. 3183
    “…Accelerated senescence is triggered by key mediators of arrhythmogenic substrates and contributes to atrial fibrillation (AF). …”
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    Atrial Fibrillation Underlies Cardiomyocyte Senescence and Contributes to Deleterious Atrial Remodeling during Disease Progression
  4. 3184
    “…PURPOSE: To explore whether oxidative stress and premature senescence occur in the anterior segment of acute primary angle-closure (APAC) eyes after increased intraocular pressure. …”
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    Occurrence of Oxidative Stress and Premature Senescence in the Anterior Segment of Acute Primary Angle-Closure Eyes
  5. 3185
    “…Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity. …”
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    Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells
  6. 3186
    “…A possible responsible mechanism may be therapy-induced senescence (TIS). TIS cells display increased senescence-associated β-galactosidase (SA-β-gal) activity and irreversible growth arrest. …”
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    Escape From Cisplatin-Induced Senescence of Hypoxic Lung Cancer Cells Can Be Overcome by Hydroxychloroquine
  7. 3187
    “…Senescent cells are responsible, in part, for tissue decline during aging. …”
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    Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche
  8. 3188
    por Jo, Hye-Ram, Jeong, Jae-Hoon
    Publicado 2022
    “…High mobility group box 2 (HMGB2) is a non-histone chromosomal protein involved in various biological processes, including cellular senescence. However, its role in cellular senescence has not been evaluated extensively. …”
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    MicroRNA-Mediated Downregulation of HMGB2 Contributes to Cellular Senescence in Microvascular Endothelial Cells
  9. 3189
    “…In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence. …”
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    Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines
  10. 3190
    “…Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs stemness and osteogenic differentiation, but the key regulators for senescence and the related osteogenesis are not well defined. …”
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    NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation
  11. 3191
    “…The genes potential regulated by PRC2 in neuroblastoma samples exhibited significant enrichment of ECM and senescence associated inflammation, supporting the clinical relevance of our results. …”
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    Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer
  12. 3192
    “…Cellular senescence is implicated in a great number of diseases including cancer. …”
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    TRPC3 shapes the ER-mitochondria Ca(2+) transfer characterizing tumour-promoting senescence
  13. 3193
    “…Finally, the results shown in this work indicate a role for ANAC087 in leaf senescence and also in rosette development.…”
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    The NAC Transcription Factor ANAC087 Induces Aerial Rosette Development and Leaf Senescence in Arabidopsis
  14. 3194
    “…Regarding these properties, it has been reported that the activities of certain enzymes are linked to senescence and fruit softening processes. This study was aimed to assess the effect of salicylic acid (SA) and chitosan (COS) as preharvest treatments on the physiology related to improving fruit conservation and preserving the marketability index of blackberry fruit. …”
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    Delayed Senescence and Marketability Index Preservation of Blackberry Fruit by Preharvest Application of Chitosan and Salicylic Acid
  15. 3195
    “…Cell senescence is critical in diverse aspects of organism life. …”
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    MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence
  16. 3196
    “…In the context of aging and age-associated diseases, Natural Killer (NK) cells have been revealed as a key cell type responsible for the immune clearance of senescent cells. Subsequently, NK cell-based therapies have emerged as promising alternatives to drug-based therapeutic interventions for the prevention and treatment of age-related disease and debility. …”
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    Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells
  17. 3197
    “…The transcriptome in TB in multiple cohorts was enriched for DNA methylation and cellular senescence. Senescence associated proteins CXCL9, CXCL10, and TNF were elevated in TB patients compared to healthy controls. …”
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    Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis
  18. 3198
    “…A methylene blue (MB)-based beta-galactosidase (β-gal) activatable molecule, Gal-MB, was developed for senescence imaging and light-triggered senolysis. When in contact with LacZ β-gal or senescence-associated β-gal (SA-β-gal), the photoinsensitive Gal-MB becomes fluorescent. …”
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    Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation
  19. 3199
    “…Senescence induction and epithelial-mesenchymal transition (EMT) events are the opposite sides of the spectrum of cancer phenotypes. …”
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    Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence
  20. 3200
    “…Exposure to γ-irradiation induced cellular senescence in N2a cells and HuD knockdown facilitated stress-induced cellular senescence. …”
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    Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype
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