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3241por Ho, Tsung-Jung, Goswami, Debakshee, Kuo, Wei-Wen, Kuo, Chia-Hua, Yen, Shih Cheng, Lin, Pi-Yu, Lin, Shinn-Zong, Hsieh, Dennis Jine-Yuan, Shibu, Marthandam Asokan, Huang, Chih-Yang“…These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health.…”
Publicado 2022
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3242por Maselli del Giudice, Alessandro, La Mantia, Ignazio, Barbara, Francesco, Ciccarone, Silvana, Ragno, Maria Sterpeta, de Robertis, Valentina, Cariti, Francesco, Barbara, Michele, D’Ascanio, Luca, Di Stadio, Arianna“…The use of this supplement should be considered at a low dosage for a prolonged period to reduce inflammation and modulate immune senescence in patients over 60 years old.…”
Publicado 2022
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3243por Roni, Md. Shyduzzaman, Sakil, Md. Arif, Aktar, Most Mohoshena, Takatsuka, Chihiro, Mukae, Kyosuke, Inoue-Aono, Yuko, Moriyasu, Yuji“…Leaf senescence accompanied by yellowing and Rubisco degradation occurs prematurely in response to various stresses. …”
Publicado 2022
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3244por Brickute, Diana, Chen, Cen, Braga, Marta, Barnes, Chris, Wang, Ning, Allott, Louis, Aboagye, Eric O.“…The accumulation of lipofuscin deposits in senescent cells is visualised using the pathology stain Sudan Black B (SBB) which is an emerging biomarker of senescence. …”
Publicado 2022
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3245“…Cellular senescence is a stable state of cell cycle arrest that plays a crucial role in the tumor microenvironment (TME) and cancer progression. …”
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3246por Mao, Yan, Xu, Jinwen, Xu, Xuejiao, Qiu, Jiayun, Hu, Zhengyun, Jiang, Feng, Zhou, Guoping“…In malignancies, cellular senescence is critical for carcinogenesis, development, and immunological regulation. …”
Publicado 2022
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3247por Borkowska, Agata, Olszewska, Aleksandra, Skarzynska, Weronika, Marciniak, Marta, Skrzeszewski, Maciej, Kieda, Claudine, Was, Halina“…The induction of therapy-induced senescence (TIS) might also be induced by oxidative stress. …”
Publicado 2022
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3248por Chan, Lok Chun, Zhang, Yuqi, Kuang, Xiaoqing, Koohi-Moghadam, Mohamad, Wu, Haicui, Lam, Theo Yu Chung, Chiou, Jiachi, Wen, Chunyi“…As such, gut microbiota dysbiosis might emerge as a metabolic link in chondrocyte senescence induced by DOCA-triggered hypertension. The underlying molecular mechanism warrants further investigation.…”
Publicado 2022
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3249por Lei, Ling, Wu, Dan, Cui, Chao, Gao, Xiang, Yao, Yanjie, Dong, Jian, Xu, Liangsheng, Yang, Mingming“…Flag leaf senescence is an important determinant of wheat yield, as leaf senescence occurs in a coordinated manner during grain filling. …”
Publicado 2022
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3250por Millan-Blanquez, Marina, Hartley, Matthew, Bird, Nicholas, Manes, Yann, Uauy, Cristobal, Boden, Scott A.“…In the absence of pollination, female reproductive organs senesce, leading to an irrevocable loss in the reproductive potential of the flower, which directly affects seed set. …”
Publicado 2022
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3251por Sanada, Yohei, Ikuta, Yasunari, Ding, Chenyang, Shinohara, Masahiro, Yimiti, Dilimulati, Ishitobi, Hiroyuki, Nagira, Keita, Lee, Minjung, Akimoto, Takayuki, Shibata, Sachi, Ishikawa, Masakazu, Nakasa, Tomoyuki, Matsubara, Kiminori, Lotz, Martin K., Adachi, Nobuo, Miyaki, Shigeru“…The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 (SAMP8) that displays a phenotype of accelerated aging. …”
Publicado 2022
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3252por Liu, Lei, Yue, Xianlin, Sun, Zewei, Hambright, William S., Feng, Qi, Cui, Yan, Huard, Johnny, Robbins, Paul D., Wang, Zhihui, Mu, Xiaodong“…Our recent study also showed that immune cells in severely dystrophic muscles develop senescence-like phenotypes, including the increased expression of senescence-associated secretory phenotype (SASP) factors and senescence markers. …”
Publicado 2022
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3253“…It has been known that senescence-associated secretory phenotype (SASP) triggers senescence of the surrounding normal cells. …”
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3254“…Leaf senescence, the final stage of leaf development, is one of the adaptive mechanisms formed by plants over a long period of evolution. …”
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3255“…Aging is a multifactorial process involving many steps including senescence. The immune system plays a critical role in aging where chronic inflammation and senescence has been shown to be detrimental. …”
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3256por Serouart, Mario, Madec, Simon, David, Etienne, Velumani, Kaaviya, Lopez Lozano, Raul, Weiss, Marie, Baret, Frédéric“…The green and senescent vegetation pixels are then separated using SVM, a shallow machine learning technique, trained over a selection of pixels extracted from images. …”
Publicado 2022
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3257por Kim, Ji-Sun, Lee, Ha Lim, Jeong, Ji Hyun, Yoon, Ye Eun, Lee, In-Ryeong, Kim, Ji Min, Wu, Chunyan, Lee, Sung-Joon“…Sandalore also inhibited the expression of senescence-associated β-galactosidase and increased p21 expression in senescent HaCaT cells in response to hydrogen peroxide. …”
Publicado 2022
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3258por Voynova, Elizaveta, Kulebyakin, Konstantin, Grigorieva, Olga, Novoseletskaya, Ekaterina, Basalova, Natalia, Alexandrushkina, Natalia, Arbatskiy, Mikhail, Vigovskiy, Maxim, Sorokina, Anna, Zinoveva, Anna, Bakhchinyan, Elizaveta, Kalinina, Natalia, Akopyan, Zhanna, Tkachuk, Vsevolod, Tyurin-Kuzmin, Pyotr, Efimenko, Anastasia“…Age-associated senescent MSCs (isolated from donors older than 65 years) and MSCs in replicative senescence (long-term culture) were treated by insulin to induce adipogenic differentiation, and the efficiency of the process was compared to MSCs from young donors. …”
Publicado 2022
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3259por Boieri, Margherita, Marchese, Emanuela, Pham, Quan Minh, Azin, Marjan, Steidl, Lauren E., Malishkevich, Anna, Demehri, Shadmehr“…In contrast to early breast cancer suppression, the antitumor immunity mediated by TSLP-stimulated CD4(+) T cells in advanced breast cancer is mediated by the induction of a senescent-like phenotype in cancer cells. Inflammatory CD4(+) T cells drive breast cancer cells into senescence by releasing interferon-gamma and tumor necrosis factor-alpha, which directly bind to their receptors on cancer cells. …”
Publicado 2022
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3260“…BACKGROUND: Cellular senescence plays crucial role in the progression of tumors. …”
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