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“…We reveal that BCBM senescent cells, induced by doxorubicin, trigger the recruitment of PD1-expressing T cells to the brain. …”
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“…In recent years, induction of cellular senescence has been shown to be important for antitumor therapy, and the link between cellular senescence and clinical prognosis and immunotherapy of hepatocellular carcinoma is still unknown. …”
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“…Loss of protein homeostasis (‘proteostasis’) and onset of cellular senescence are two conserved hallmarks of ageing. Healthy proteostasis relies on tightly-regulated intracellular quality control circuits that co-ordinate clearance of potentially toxic misfolded proteins arising from various internal or external stresses throughout an organism’s lifespan. …”
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“…In addition, senescent cells accumulate in premalignant lesions, in part, as a product of oncogene hyperactivation, reflecting one element of the tumor suppressive function of senescence. …”
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“…We also identified a small population of nuclei that express CDKN1A, present only in aged samples, consistent with p21(cip1)-driven senescence in this subpopulation. Overall, our findings identify unique cellular subpopulations in aged and sarcopenic skeletal muscle, which will facilitate the development of new therapeutic strategies to combat age-related frailty.…”
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“…The overlapping DEGs and SRGs constituted 14 DESRGs, including 4 senescence suppressor genes and 10 senescence inducible genes. …”
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“…However, the mechanism by which SO(2) regulates the senescence of vascular endothelial cells induced by HG has not yet been clarified, so it is necessary to find effective tools to elucidate the effect of SO(2) on senescence of HUVECs. …”
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“…Thus, in addition to classical ligand and tyrosine kinase-dependent (LYK-D) signaling, the IR regulates a second, ligand and tyrosine kinase-independent (LYK-I) pathway, which regulates the cellular machinery involved in senescence, matrix interaction and response to extrinsic challenges.…”
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“…DNA damage is the major cause of senescence and apoptosis; however, the manner by which DNA-damaged cells become senescent remains unclear. …”
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“…However, functions and mechanisms of RNA binding proteins in regulating senescence remain elusive. Here we reported that the RNA binding protein RBM4 contributed to cellular senescence. …”
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“…MATERIALS AND METHODS: Cellular senescence was assessed using senescence‐associated β‐galactosidase staining. …”
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“…Mechanisms regulating flower senescence are not fully understood in any species and are particularly complex in composite flowers. …”
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“…METHODS: The goal of this research was to investigate how AP (at 0.5% and 1.0%) influences senescence-related physiological parameters and antioxidant capacity of ‘Jinshayou’ pummelo fruits stored at 20°C for 90 d. …”
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“…INTRODUCTION: Cellular senescence is a hallmark of tumors and has potential for cancer therapy. …”
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“…Cell apoptosis was evaluated by TUNEL assay and western blot analysis. Cell senescence was assessed by senescence-associated β-galactosidase staining and western blot analysis. …”
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“…Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes. …”
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“…Accumulation of evidence has suggested that chondrocyte senescence plays a significant role in OA development. …”
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“…Simultaneously, the number of senescent cells increased in IPF. Epithelial cell senescence, an important component of epithelial cell dysfunction, plays a key role in IPF pathogenesis. …”
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“…This prevents aberrant and irreversible cell cycle re‐entry and senescence events of neurons. Together, our findings offer a direct connection between binge‐drinking behaviour and its irreversible impact on the brain, which makes it a potential risk factor for dementia.…”
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