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  1. 3281
    “…Additionally, we analyzed a small number of samples from adult fish at various stages of senescence. Results from these samples suggest that microbiome composition associated with gut integrity, and that the microbial communities of corticosteroid treated juveniles shift in composition toward those of senescent adults. …”
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    Gut microbiome composition associates with corticosteroid treatment, morbidity, and senescence in Chinook salmon (Oncorhynchus tshawytscha)
  2. 3282
    “…First, we describe the in vitro reprogramming procedure using conditioned medium derived from senescent cells. Next, to explore the impact of senescence on in vivo reprogramming, we detail the steps to identify senescent and reprogrammed cells in mouse skeletal muscle, followed by semi-automatic quantification. …”
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    Protocol for quantitative evaluation of the impact of paracrine senescence on cellular reprogramming in cultured cells and mouse models
  3. 3283
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    Author Correction: Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
  4. 3284
    “…Together, our data strengthen the importance of senescence and NRF2 pathways as potential therapeutic options to combat VC in CKD.…”
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    Implications of Senescent Cell Burden and NRF2 Pathway in Uremic Calcification: A Translational Study
  5. 3285
    “…Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. Senescence is a natural cellular response to stressors. …”
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    Implication of Cellular Senescence in Osteoarthritis: A Study on Equine Synovial Fluid Mesenchymal Stromal Cells
  6. 3286
    por Yan, Feilong, Yu, Zhenwen, Shi, Yu
    Publicado 2023
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    Optimized border irrigation delays winter wheat flag leaf senescence and promotes grain filling
  7. 3287
    “…Improved understanding of the degree to which latent senescence signalling persists in tumours might identify intervention strategies to provoke "accelerated senescence" responses as a therapeutic outcome. …”
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    Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma
  8. 3288
    “…BACKGROUND: We observed the effects of nuclear factor E2-related factor 2 (Nrf2) downregulation via intrahippocampal injection of a lentiviral vector on cognition in senescence-accelerated mouse prone 8 (SAMP8) to investigate the role of the (Nrf2)/antioxidant response element (ARE) pathway in age-related changes. …”
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    Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence
  9. 3289
    “…Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. …”
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    Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
  10. 3290
    “…Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. …”
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    Chemotherapy‐Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA‐Mediated PKR Activation
  11. 3291
    “…Mechanism studies showed that iPSC-sEVs reversed the loss of Rictor and downstream p-AKT (s473) in senescent microglia, which was involved in the senescence and pro-inflammatory phenotype regulation of microglia. …”
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    iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice
  12. 3292
    “…Interestingly, an enrichment analysis uncovered a TGFβ-pathway activation, together with AKT inactivation, in response to metformin + simvastatin combination, which might be linked to an induction of the senescence-state, the associated secretory-phenotype, and to the dysregulation of spliceosome components. …”
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    Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence
  13. 3293
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    Transcriptomic, metabolomic, and ATAC-seq analysis reveal the regulatory mechanism of senescence of post-harvest tomato fruit
  14. 3294
    “…Recently, cellular senescence emerged as a fundamental characteristic of solid malignancies. …”
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    A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
  15. 3295
    “…MATERIALS AND METHODS: ICR mice with CCl(4)-induced hepatic fibrosis were supplemented with Sch B (40 mg/kg) for 30 d and LX2 cells were treated with Sch B (5, 10 and 20 μM) for 24 h. Cellular senescence was assessed by senescence-related indicators senescence-associated β-galactosidase (SA-β-gal) activity and the expression of p16, p21, p53, γ-H2AX, H3K9me3, TERT, TRF1, and TRF2. …”
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    Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy
  16. 3296
    “…Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. …”
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    Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail
  17. 3297
    “…RESULTS: CSE induced cellular senescence with intracellular accumulation of cellular senescence biomarkers (p16, p21 and p27) and increased secretion of senescence-related secretory phenotypic (SASP) factors (IL-6, IL-8, and CCL3). …”
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    Bufei Yishen Formula Inhibits the Cell Senescence in COPD by Up-Regulating the ZNF263 and Klotho Expression
  18. 3298
    “…Nevertheless, adoptive transfer of macrophages activated ex vivo with VSSP inhibited Pten(pc−/−); Trp53(pc−/−) tumor growth through reduction of angiogenesis and tumor cell proliferation and induction of senescence. Taken together, our results highlight the rationale of exploiting macrophage functional programming as a promising strategy for CRPC therapy, with particular emphasis on ex vivo-activated proinflammatory macrophage adoptive transfer. …”
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    VSSP-activated macrophages mediate senescence and tumor inhibition in a preclinical model of advanced prostate cancer
  19. 3299
    “…BACKGROUND: High expression of immune checkpoints (ICs) and senescence molecules (SMs) contributes to T cell dysfunction, tumor escape, and progression, but systematic evaluation of them in co-expression patterns and prognosis in acute myeloid leukemia (AML) was lacking. …”
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    Optimal combination of immune checkpoint and senescence molecule predicts adverse outcomes in patients with acute myeloid leukemia
  20. 3300
    “…Previous studies have shown that cellular senescence is a promising therapeutic strategy to limit melanoma cell progression. …”
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    Senescence-Related lncRNA Signature Predicts Prognosis, Response to Immunotherapy and Chemotherapy in Skin Cutaneous Melanoma
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