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  1. 3301
    “…Recently, we showed that cellular senescence markers can be tracked in PBMCs of aMCI patients, so we here investigated whether these senescence markers are dependent on having a history of cancer. …”
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    Cancer History Avoids the Increase of Senescence Markers in Peripheral Cells of Amnestic Mild Cognitive Impaired Patients
  2. 3302
    “…Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging. …”
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    Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells
  3. 3303
    “…Current theories cannot explain the progression of radiation ulcers. Cellular senescence refers to as irreversible growth arrest that occurs after exposure to stress, which contributes to tissue dysfunction by inducing paracrine senescence, stem cell dysfunction and chronic inflammation. …”
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    Characterization of cellular senescence in radiation ulcers and therapeutic effects of mesenchymal stem cell-derived conditioned medium
  4. 3304
    “…Finally, indoxyl sulfate signaling contributes to the senescence of tubular epithelial cells during injury.…”
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    Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence
  5. 3305
    “…Here, we demonstrate that endothelial cell (EC) senescence plays a negative role in pulmonary hypertension via juxtacrine interaction with smooth muscle cells (SMCs). …”
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    Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
  6. 3306
    “…Extensive literature has raised many concerns about its possible involvement in the pathogenesis of kidney diseases, but its contribution has not been extensively studied. During cellular senescence, the interference of lipofuscin with cellular functions promotes further senescence, causing cellular malfunction. …”
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    Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney
  7. 3307
    “…Kidneys and hearts were screened for a suite of cellular senescence markers (senescence-associated β-galactosidase, p16(INK4a), p21, γH2AX). …”
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    Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
  8. 3308
    “…Our findings reveal that spermidine supplementation improved the declined angiogenic capacity of senescent ECs, including migration and tube-formation, without affecting the senescence phenotypes. …”
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    Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice
  9. 3309
    “…This study investigated metabolite changes in three pomelo cultivars during postharvest senescence using (1)H NMR-based metabolic profiling. …”
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    (1)H NMR-Based Metabolic Profiling to Follow Changes in Pomelo Cultivars during Postharvest Senescence
  10. 3310
    “…In patients, we found an increase in EMT markers, AGE/RAGE, and senescence signaling activation compared to controls. …”
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    PPAR-Gamma Orchestrates EMT, AGE, and Cellular Senescence Pathways in Colonic Epithelium and Restrains the Progression of IBDs
  11. 3311
    “…Aging is a major risk factor for most chronic diseases, including osteoporosis, and is characterized by an accumulation of senescent cells in various tissues. MicroRNAs (miRNAs) are critical regulators of bone aging and cellular senescence. …”
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    MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence
  12. 3312
    “…OBJECTIVES: Cellular senescence has been proposed as a pathophysiologic driver in the development of pelvic organ prolapse (POP), especially during aging. …”
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    Quantification of senescence‐associated secretory phenotype proteins in the vaginal secretions of pre‐ and postmenopausal women with and without prolapse
  13. 3313
    “…In vitro, RLDC also induced senescence in mouse proximal tubular (BUMPT) cells. …”
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    Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity
  14. 3314
    “…Bone marrow stem cells (BMSCs) are a promising source of seed cells in bone tissue engineering, which needs a great quantity of cells. Cell senescence occurs as they are passaged, which could affect the therapeutic effects of cells. …”
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    ZIM1 Combined with Hydrogel Inhibits Senescence of Primary PαS Cells during In Vitro Expansion
  15. 3315
    “…Using S-phase synchronized RPE1-hTERT cells exposed to the DNA damaging agent, methyl methanesulfonate, we show the existence of a redox state associated with replication stress-induced senescence termed senescence-associated redox state (SA-redox state). …”
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    A superoxide-driven redox state promotes geroconversion and resistance to senolysis in replication-stress associated senescence
  16. 3316
    “…These results indicate that local clearance of senescent brain cells is a potential therapy on AIS, and demonstrate the correlation between neuronal senescence and pathogenesis of AIS.…”
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    Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice
  17. 3317
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    Corrigendum: Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy
  18. 3318
    “…Tightly regulated age-related physiological senescence and various biotic and abiotic stressors drive overall greenness decay dynamics under field conditions. …”
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    Combining High-Resolution Imaging, Deep Learning, and Dynamic Modeling to Separate Disease and Senescence in Wheat Canopies
  19. 3319
    “…However, there are few reports on cellular senescence-associated lncRNAs in lung adenocarcinoma (LUAD). …”
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    A predictive molecular signature consisting of lncRNAs associated with cellular senescence for the prognosis of lung adenocarcinoma
  20. 3320
    “…Therefore, the role of senescent CD8(+) T cells in tumor immunity remains to be elucidated. …”
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    Senescent CD8 (+) T cells acquire NK cell‐like innate functions to promote antitumor immunity
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