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  1. 3321
    “…Similarly, blocking autophagy in stem cell-like GBM tumor subpopulations induced senescence-associated growth arrest without hampering stemness capacity or inducing apoptosis while reciprocally upregulating glycolytic activity. …”
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    Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations
  2. 3322
    “…Senescence is a driving mechanism for MSC dysfunction with advancing age. …”
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    Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells
  3. 3323
    “…Here, we test the hypothesis that PTX induces endothelial senescence, which impairs microvascular function and contributes to the genesis of cognitive decline. …”
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    Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain
  4. 3324
    “…Interestingly, ATF7 expression was gradually reduced during cellular senescence. Loss of ATF7 induced cellular senescence, while overexpression delayed senescence progress and senescence-associated secretory phenotype (SASP) secretion. …”
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    Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation
  5. 3325
    por Doll, Nicolas M
    Publicado 2023
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    Eternal nodules to fix the nitrogen issue: Promotion of soybean nodule senescence by a NAC/CYP module
  6. 3326
    “…Senescence-associated (SA) CD4(+) T cells, which increase with age, may underlie the development of autoimmunity and chronic inflammation, but their pathological function remains understudied. …”
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    Protocol for the isolation of mouse senescence-associated CD4(+) T cells using flow cytometry and functional assays
  7. 3327
    “…In our study, we demonstrated that cGAS-STING signaling pathway-mediated cellular senescence played a critical role in the inflammatory reaction and provided a therapeutic solution for HFS. …”
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    DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug
  8. 3328
    “…BACKGROUND: Cellular senescence plays an essential role in the development and progression of end-stage renal disease (ESRD). …”
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    Identifying cellular senescence associated genes involved in the progression of end-stage renal disease as new biomarkers
  9. 3329
    “…CONCLUSIONS: Our data demonstrated that melatonin significantly prevented the M2 polarization of senescent macrophage/microglia by inhibiting the IL-10/STAT3 pathway, and eventually attenuated senescence-associated CNV. …”
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    Therapeutic Benefit of Melatonin in Choroidal Neovascularization During Aging Through the Regulation of Senescent Macrophage/Microglia Polarization
  10. 3330
    “…However, the prognostic roles of senescence and oxidative stress remain obscure in breast cancer. …”
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    Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma
  11. 3331
    “…Protein expression was assessed by western blotting and immunofluorescence, oxidative stress was evaluated using dihydroethidium, nitric oxide was evaluated using the Griess reaction, and cellular senescence was assessed based on senescence-associated beta-galactosidase (SA‐β‐gal) activity and the expression of senescence markers. …”
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    Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes
  12. 3332
    “…BACKGROUND: Cellular senescence occurs throughout life and can play beneficial roles in a variety of physiological processes, including embryonic development, tissue repair, and tumor suppression. …”
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    Prognosis signature for predicting the survival and immunotherapy response in esophageal carcinoma based on cellular senescence-related genes
  13. 3333
    “…BACKGROUND: Cellular senescence, a state of stable growth arrest, is intertwined with human cancers. …”
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    Cellular senescence throws new insights into patient classification and pharmacological interventions for clinical management of hepatocellular carcinoma
  14. 3334
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    Global Gene Expression of Post-Senescent Telomerase-Negative ter1Δ Strain of Ustilago maydis
  15. 3335
    “…This finding was validated in kidney biopsy specimens collected from patients with DKD, associated with renal tubular senescence and degenerative changes. In vitro in renal tubular epithelial cells, exposure to a diabetic milieu, stimulated with high ambient glucose and TGFβ1, elicited premature senescence, as evidenced by staining for senescence-associated β-galactosidase activity and increased expression of p16(INK4A), and p53. …”
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    Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult
  16. 3336
    “…Flower senescence is commonly enhanced by the endogenous hormone ethylene and suppressed by the gibberellins (GAs) in plants. …”
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    A petunia transcription factor, PhOBF1, regulates flower senescence by modulating gibberellin biosynthesis
  17. 3337
    “…As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. …”
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    MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
  18. 3338
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    Retracted: The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8
  19. 3339
    “…Plasmalemma-vesicle-associated protein (PLVAP) has been characterized as a marker of LSEC in CLD; notably we found that PLVAP upregulation strongly correlated with markers of tissue senescence. Furthermore, exposure of human LSEC to the senescence-associated secretory phenotype (SASP) led to a significant upregulation of PLVAP. …”
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    The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration
  20. 3340
    “…Background: An increasing number of studies are shown how crucial a role cellular senescence plays in tumor development. In this study, we developed a senescence-related lncRNA prognostic index (SRLPI) to forecast radiosensitivity and the probability of biochemical recurrence (BCR) in patients with prostate cancer (PCa). …”
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    Identification of senescence-related lncRNA prognostic index correlating with prognosis and radiosensitivity in prostate cancer patients
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