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  1. 321
    “…Leaf senescence is a developmentally programmed and degenerative process which comprises the last stage of the life cycle of leaves. …”
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    Exogenous Melatonin Delays Dark-Induced Grape Leaf Senescence by Regulation of Antioxidant System and Senescence Associated Genes (SAGs)
  2. 322
    “…Cell senescence is accompanied, and in part mediated, by changes in chromatin, including histone losses, but underlying mechanisms are not well understood. …”
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    Rap1‐mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence
  3. 323
    por Pulakat, Lakshmi, Chen, Howard H.
    Publicado 2020
    “…Cardiovascular aging in humans is characterized by structural pathologic remodeling including cardiac and vascular fibrosis, hypertrophy, stiffness, micro- and macro-circulatory impairment, left ventricular diastolic dysfunction precipitating heart failure with either reduced or preserved ejection fraction, and cardiovascular cell death. Cellular senescence, an important hallmark of aging, is a critical factor that impairs repair and regeneration of damaged cells in cardiovascular tissues whereas autophagy, an intracellular catabolic process is an essential inherent mechanism that removes senescent cells throughout life time in all tissues. …”
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    Pro-Senescence and Anti-Senescence Mechanisms of Cardiovascular Aging: Cardiac MicroRNA Regulation of Longevity Drug-Induced Autophagy
  4. 324
    por Lee, Gung
    Publicado 2022
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    Cellular Senescence: The Villain of Metabolic Disease?: Discovery of a distinct senescent cell population in obesity-induced metabolic dysfunction
  5. 325
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    Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells
  6. 326
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    Senescent Cells Accumulate in Systemic Sclerosis Skin
  7. 327
    “…Evidence is accumulating that the earliest stages of the DNA damage response can direct cells toward senescence instead of other cell fates. In particular, tightly regulated signaling through Mitogen-Activated Protein Kinases (MAPKs) in early senescence can lead to a sustained pro-survival program and suppress a pro-apoptotic program. …”
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    MAPKs in the early steps of senescence implemEMTation
  8. 328
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    Editorial: Cardiovascular cell senescence in aging and disease
  9. 329
    “…BACKGROUND: Cellular senescence is a cell fate in response to diverse forms of age-related damage and stress that has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). …”
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    Biomarkers of cellular senescence in idiopathic pulmonary fibrosis
  10. 330
    “…Cellular senescence induces inflammation and is now considered one of the causes of organismal aging. …”
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    Sesamin Metabolites Suppress the Induction of Cellular Senescence
  11. 331
    “…The accumulation of senescent cells is recognised as a driver of tissue and organismal ageing. …”
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    TFEB‐dependent lysosome biogenesis is required for senescence
  12. 332
    “…Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues. …”
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    Increased cell senescence in human metabolic disorders
  13. 333
    por Wang, Xiaojie, Ramos, Raul, Phan, Anne Q., Yamaga, Kosuke, Flesher, Jessica L., Jiang, Shan, Oh, Ji Won, Jin, Suoqin, Jahid, Sohail, Kuan, Chen-Hsiang, Nguyen, Truman Kt, Liang, Heidi Y., Shettigar, Nitish Udupi, Hou, Renzhi, Tran, Kevin H., Nguyen, Andrew, Vu, Kimberly N., Phung, Jennie L., Ingal, Jonard P., Levitt, Katelyn M., Cao, Xiaoling, Liu, Yingzi, Deng, Zhili, Taguchi, Nobuhiko, Scarfone, Vanessa M., Wang, Guangfang, Paolilli, Kara Nicole, Wang, Xiaoyang, Guerrero-Juarez, Christian F., Davis, Ryan T., Greenberg, Elyse Noelani, Ruiz-Vega, Rolando, Vasudeva, Priya, Murad, Rabi, Widyastuti, Lily Halida Putri, Lee, Hye-Lim, McElwee, Kevin J., Gadeau, Alain-Pierre, Lawson, Devon A., Andersen, Bogi, Mortazavi, Ali, Yu, Zhengquan, Nie, Qing, Kunisada, Takahiro, Karin, Michael, Tuckermann, Jan, Esko, Jeffrey D., Ganesan, Anand K., Li, Ji, Plikus, Maksim V.
    Publicado 2023
    “…This finding identifies senescent cells and their secretome as an attractive therapeutic target in regenerative disorders.…”
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    Signalling by senescent melanocytes hyperactivates hair growth
  14. 334
    “…Background: Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. …”
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    Senescence and senotherapies in biliary atresia and biliary cirrhosis
  15. 335
    “…These diseases are often attributed to cellular senescence, in which cells become disengaged from the cell cycle and inert to cell death. …”
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    Cellular Senescence, Inflammation, and Cancer in the Gastrointestinal Tract
  16. 336
    por Farr, Joshua Nicholas
    Publicado 2023
    “…Accumulating evidence has established that numerous boneresident cell types become susceptible to cellular senescence with old age. Recent work also demonstrates that T2D causes the premature accumulation of senescent osteocytes during young adulthood, at least in mice, although it remains to be seen which other bone-resident cell types become senescent with T2D. …”
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    Skeletal Senescence with Aging and Type 2 Diabetes
  17. 337
    por Nerstedt, Annika, Smith, Ulf
    Publicado 2023
    “…The abundance of senescent cells increases not only with aging but also in hypertrophic obesity independent of age. …”
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    The impact of cellular senescence in human adipose tissue
  18. 338
    por Yang, Kailing, Li, Xiaojia, Xie, Keping
    Publicado 2023
    “…Tumor is a representative of cell immortalization, while senescence irreversibly arrests cell proliferation. …”
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    Senescence program and its reprogramming in pancreatic premalignancy
  19. 339
    “…We have previously found that the expression of spermine oxidase (SMOX) increases with age; however, the relationship between SMOX expression and cellular senescence remains unclear. Therefore, we investigated the relationship between increased SMOX expression and cellular senescence using human-liver-derived HepG2 cells. …”
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    Inhibition of Polyamine Catabolism Reduces Cellular Senescence
  20. 340
    “…The final stage of petal development is associated with flower senescence, which is an irreversible process involving programmed cell death, and premature senescence of cut flowers often results in major losses in quality during postharvest handling. …”
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    Molecular understanding of postharvest flower opening and senescence
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