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  1. 3381
    “…Lysosomal transfer is associated with the preservation of lysosomal pH gradient, functionally reconstituting lysosomal pool of stressed cells and improving endothelial cell viability, reducing premature senescence and apoptosis. In vivo, adoptive transfer of EPC to streptozotocin-diabetic mice results in a TNT-dependent reduction of senescent endothelial cells and correction of endothelium-dependent vasorelaxation. …”
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    Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool
  2. 3382
    “…METHODOLOGY/PRINCIPAL FINDINGS: Cultured HLECs (SRA01/04) were subjected to prolonged exposure to low dose of H(2)O(2) to simulate senescence. After being exposed to 50 µM H(2)O(2) for 2 weeks, HLECs senescent-morphological changes appeared, cell viability decreased dramatically, cell proliferation reduced from 37.4% to 16.1%, and senescence-associated β-galactosidase activity increased from 0 to 90.3%. …”
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    Up-Regulation of NDRG2 in Senescent Lens Epithelial Cells Contributes to Age-Related Cataract in Human
  3. 3383
    “…In conclusion, CD4+ NKG2D+ represent a subset of highly differentiated T cells which characterizes the senescence of the immune system.…”
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    NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system
  4. 3384
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    Differing Pattern of Ambulatory Blood Pressure in Very Elderly Men Expresses Dynamics in Atherosclerotic Load in the Senescence
  5. 3385
    “…The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging topic in aging research. …”
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    Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective
  6. 3386
    “…This study determined the molecular mechanism of γ-tocotrienol, a vitamin E homolog, in the prevention of cellular aging in human diploid fibroblasts using the expression of senescence-associated genes. METHODS: Primary cultures of young, pre-senescent, and senescent fibroblast cells were incubated with γ-tocotrienol for 24 h. …”
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    Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
  7. 3387
    “…Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observed. …”
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    A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations
  8. 3388
    “…Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. …”
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    Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
  9. 3389
    “…Previously we showed that senescence-accelerated OXYS rats develop retinopathy and cataract, which are comparable to human AMD and senile cataract. …”
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    Quantitative trait loci on chromosome 1 for cataract and AMD-like retinopathy in senescence-accelerated OXYS rats
  10. 3390
    “…Then, the EPCs senescence would be detected by senescence associated β-galactosides (SA-β-gal) staining. …”
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    The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus
  11. 3391
    “…We recently identified senescence marker protein-30 as the lactone-hydrolyzing enzyme gluconolactonase, which is involved in vitamin C biosynthesis. …”
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    Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice
  12. 3392
    “…Ectopic expression of some of these induced microRNAs increased the expression of senescence markers and induced growth arrest and senescence in primary melanocytes. …”
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    A Micro-RNA Connection in BRaf (V600E)-Mediated Premature Senescence of Human Melanocytes
  13. 3393
    “…The suppression of TWIST1 in human lung cancer cells also induced cellular senescence. Hence, TWIST1 is a critical regulator of cellular senescence programs, and the suppression of TWIST1 in human tumors may be an effective example of pro-senescence therapy.…”
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    Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis
  14. 3394
    “…p16(Ink4a) is a tumor suppressor and a marker for cellular senescence. Previous studies have shown that p16(Ink4a) plays an important role in the response to DNA damage signals caused by telomere dysfunction. …”
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    Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction
  15. 3395
    por Quitschke, Wolfgang W.
    Publicado 2012
    “…Continual exposure of NT2/D1 cells for 4–6 days to either preparation in cell culture media reduced cell division (1–5 µM), induced senescence (6–7 µM) or comprehensive cell death (8–10 µM) in a concentration-dependent manner. …”
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    Curcuminoid Binding to Embryonal Carcinoma Cells: Reductive Metabolism, Induction of Apoptosis, Senescence, and Inhibition of Cell Proliferation
  16. 3396
    “…Senescence has been implicated as an important mechanism of tumour suppression in a number of human malignancies, including colorectal cancer (CRC). …”
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    p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
  17. 3397
    “…Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. …”
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    Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence
  18. 3398
    “…H-RasV12 expressing cells also show premature senescence followed by cell death, induced by autophagy and apoptosis. …”
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    Cellular Redox Imbalance and Changes of Protein S-glutathionylation Patterns Are Associated with Senescence Induced by Oncogenic H-Ras
  19. 3399
    “…The link between senescence and tumor suppression supports the hypothesis that a loss-of-function screen measuring bona fide senescence marker activation should identify candidate tumor suppressors. …”
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    A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3
  20. 3400
    “…This suggests that stress-induced premature cellular senescence via p38 activation is restricted to a small subset of progeroid syndromes. …”
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    p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes
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