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  1. 3401
    “…BACKGROUND: Senescence-accelerated mice (SAM) are a series of mouse strains originally derived from unexpected crosses between AKR/J and unknown mice, from which phenotypically distinct senescence-prone (SAMP) and -resistant (SAMR) inbred strains were subsequently established. …”
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    Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
  2. 3402
    por Acharyya, Swarnali
    Publicado 2013
    “…In a second study on HER2-driven breast cancer, Angelini and colleagues investigate how the constitutively active, truncated carboxy-terminal fragment of HER2, p95HER2, promotes metastatic progression through non-cellautonomous secretion of factors from senescent cells. These new findings advance our understanding of HER2 biology in the context of HER2 activation as well as offer new insights into our understanding of drug sensitivity and metastatic progression.…”
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    Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression
  3. 3403
    “…Oxidative stress is a determining factor of cellular senescence and aging and a potent inducer of the tumour-suppressor p53. …”
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    Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
  4. 3404
    “…Cellular senescence is post-mitotic or oncogene-induced events combined with nuclear remodeling. …”
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    The Transcriptional Cofactor MCAF1/ATF7IP Is Involved in Histone Gene Expression and Cellular Senescence
  5. 3405
    “…AAD inactivation impaired cell proliferation, promoted premature senescence and compromised Chk1 signalling following UV irradiation. …”
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    An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence
  6. 3406
    “…Upon senescence, both subtelomeres were characterized by a decrease in markers of constitutive heterochromatin, suggesting relative chromatin relaxation. …”
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    Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: Commonalities and differences between chromosomes
  7. 3407
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    MicroRNA profile comparison of the corneal endothelia of young and old mice: implications for senescence of the corneal endothelium
  8. 3408
    “…It has also been reported that miR-34c-5p may be involved in senescence-related mechanisms. We propose that miR-34c-5p may play a crucial role in senescence of normal human primary dermal fibroblasts. …”
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    Elevated miR-34c-5p Mediates Dermal Fibroblast Senescence by Ultraviolet Irradiation
  9. 3409
    “…DNA damage can lead to the induction of cellular senescence. In particular, we showed that exposure to ionizing radiation (IR) leads to the senescence of bone marrow-derived multipotent stromal cells (MSC) and osteoblast-like stromal cells (OB–SC), a phenotype associated with bone loss. …”
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    Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53
  10. 3410
    “…Of note, senescent hMESCs exhibited high resistance to apoptosis. …”
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    Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium
  11. 3411
    “…In this study, t-BHP-induced premature senescence model in human fibroblasts was chosen to explore the protective effects of a curcuminoid, bisdemethoxycurcumin (BDMC), on cellular senescence. …”
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    Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
  12. 3412
    “…Cellular senescence was induced using a stress-induced premature senescence protocol consisting of three successive once-daily exposure of cells to 1×10(−8) mol/L angiotensin II and was dependent upon the type-1 angiotensin II receptor. …”
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    A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells()
  13. 3413
    “…Because the mRNA level of the senescence (aging)-related gene was significantly elevated in samples from VIM(SA/SA), the lens phenotype suggests a possible causal relationship between chromosomal instability and premature aging.…”
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    Defect of Mitotic Vimentin Phosphorylation Causes Microophthalmia and Cataract via Aneuploidy and Senescence in Lens Epithelial Cells
  14. 3414
    “…BACKGROUND: Senescence marker protein 30 (SMP30), which was originally identified as an aging marker protein, is assumed to act as a novel anti-aging factor in the liver, lungs and brain. …”
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    Senescence Marker Protein 30 Has a Cardio-Protective Role in Doxorubicin-Induced Cardiac Dysfunction
  15. 3415
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    Correction: Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence
  16. 3416
    Publicado 2014
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    Correction: Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence
  17. 3417
    por Manukyan, Maria, Singh, Prim B.
    Publicado 2014
    “…Introduction of “reprogramming factors”, Oct4, Sox2, Klf4, cMyc and Lin28, into senescent fibroblasts and measuring the changes in HP1β mobility as reprogramming proceeds shows that the mobility of HP1β in senescent cells increases and by day 9 is the same as that found in young fibroblasts. …”
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    Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states
  18. 3418
    “…BACKGROUND: Tracking of replicative senescence is of fundamental relevance in cellular therapy. …”
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    Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes
  19. 3419
    “…BACKGROUND: Cellular senescence can be induced by a variety of extrinsic stimuli, and sustained exposure to sunlight is a key factor in photoaging of the skin. …”
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    Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts
  20. 3420
    “…Here, we describe the effects of SIRT1, a NAD(+)-dependent deacetylase, on age-related MSCs senescence. Knockdown of SIRT1 in young MSCs induced cellular senescence and inhibited cell proliferation whereas overexpression of SIRT1 in aged MSCs reversed the senescence phenotype and stimulated cell proliferation. …”
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    SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
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