“…In this study, curcumin promoted the expression of senescence marker Hmga1 in rat fibrotic liver. In addition, curcumin increased the number of senescence-associated β-galactosidase-positive HSCs in vitro. …”
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“…Both mutants showed earlier and stronger senescence than the wildtype indicating the importance of a functioning ascorbate and glutathione cycle in the induction and regulation of senescence. …”
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“…Conversely, downregulation of XAF1 in premature senescent cells partially overcame endothelial cell senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by XAF1 induction. …”
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“…We demonstrate that PLL provides favourable microenvironment for MSC culture by reversing the replicative senescence. This method will significantly contribute to effective preparation of MSCs for cellular therapy.…”
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“…A novel NAC1‐type transcription factor (hereafter TaNAC‐S) was identified in wheat, with gene expression located primarily in leaf/sheath tissues, which decreased during post‐anthesis leaf senescence. Expression of TaNAC‐S in the second leaf correlated with delayed senescence in two doubled‐haploid lines of an Avalon × Cadenza population (lines 112 and 181), which were distinct for leaf senescence. …”
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“…OBJECTIVES: Cellular senescence is a state of irreversible growth arrest induced either by telomere shortening (replicative senescence) or stress. …”
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“…Phosphate and its allocation mediated by PHT4;6 is critical to prevent onset of dark-induced senescence.…”
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“…However, a decline in cell growth was observed at passage 4 onwards and it was further deciphered through apoptosis, cell cycle, and senescence assays. Despite the enhanced cell viability at later passages (P4-5), the expression of senescence marker, β-galactosidase, was significantly increased at passage 5. …”
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“…Drought inhibits plant growth and can also induce premature senescence. Here we identify a transcription factor, ABA INSENSITIVE GROWTH 1 (ABIG1) required for abscisic acid (ABA) mediated growth inhibition, but not for stomatal closure. …”
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“…The observed deficiencies in DNA repair factors in senescent cells could contribute to the genomic instability that allows senescence bypass and tumorigenesis.…”
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“…Here, we show that the expression of the main H(2)S producing enzyme, CBS, and production of H(2)S are coordinately diminished in replicative senescent adult human dermal fibroblasts. The reduced production of H(2)S falls within the same time-frame that the hallmarks of replicative senescence appear including accumulation of SA–β-Gal, enhanced expression of p16, p21, and RRM2B while the expression of RRM2, hTERT, SIRT1, NAMPT, and NAD/NADH ratio all fall. …”
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“…Overexpression of Ghd2 resulted in significantly reduced drought resistance, while its knockout mutant showed the opposite phenotype. The earlier senescence symptoms and the transcript up-regulation of many senescence-associated genes (SAGs) in Ghd2-overexpressing transgenic rice plants under drought stress conditions indicate that Ghd2 plays essential roles in accelerating drought-induced leaf senescence in rice. …”
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“…In addition, SIRT6 silencing significantly prevented the growth of HCC cell lines by inducing cellular senescence in the p16/Rb- and p53/p21-pathway independent manners. …”
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“…However, the role of SIRT6 in cellular senescence has not been fully understood. Here, we show that SIRT6 repressed the expression of p27(Kip1) (p27) in cellular senescence. …”
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“…Therefore, this study concludes that miR-23a-regulated autophagy is a novel and important regulator of ultraviolet-induced premature senescence and AMBRA1 is a rate-limiting miRNA target in this pathway.…”
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“…Senescence is the final stage of leaf growth and development. …”
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“…Additionally, enhanced cellular senescence, determined by senescence-associated beta-galactosidase staining, was obviously attenuated by p38-MAPK inhibitor SB203580. …”
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“…Senescence marker protein 30 (SMP30) has been identified as a tumor-related molecule of hepatocellular carcinoma (HCC). …”
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