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  1. 3481
    “…In this study, we sought to explore the role of lncRNAs in cellular senescence. Here, we report that the lncRNA AK156230 was downregulated during replicative senescence in mouse embryonic fibroblasts (MEFs), and knockdown of AK156230 promotes a robust senescence phenotype, including increase in the numbers of the senescence-associated β-galactosidase-positive cells, decrease of cell proliferation, accumulation of cells in the G2/M phase and reduction of autophagic activity. …”
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    Identification of the lncRNA, AK156230, as a novel regulator of cellular senescence in mouse embryonic fibroblasts
  2. 3482
    “…These results show that non-fibrogenic, SMA-positive myofibroblasts can be directly generated through induction of fibroblast senescence and suggest that senescence and myofibroblast differentiation are closely linked processes.…”
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    Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
  3. 3483
    “…Nevertheless, numerous findings suggest that senescent cells may conversely promote tumor progression through the development of the senescence-associated secretome they produce. …”
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    Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes
  4. 3484
    “…Moreover, RabF1 is highly expressed during senescence and RabF1(OE) lines were more tolerant of dark-induced senescence (DIS) than wild-type and rabF1.…”
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    Arabidopsis RabF1 (ARA6) Is Involved in Salt Stress and Dark-Induced Senescence (DIS)
  5. 3485
    “…Anticancer therapies that induce DNA damage tend to trigger senescence in cancer cells, a process known as therapy-induced senescence (TIS). …”
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    Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice
  6. 3486
    “…Increased oxidative stress, pro-inflammatory and pro-senescence responses (DNA damage and HDAC2 reduction) can result in dysregulated repair due to proinflammatory and pro-senescence responses in periodontal cells. …”
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    E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts
  7. 3487
    “…Age-associated, chronic low-grade inflammation augments the susceptibility and severity of pneumonia in the elderly. Cellular senescence, one of the hallmarks of aging, has its own characteristics, cell growth arrest and senescence-associated secretory phenotype (SASP). …”
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    The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections
  8. 3488
    “…In particular, we reveal that the expression level of BRG1 is inversely correlated with p21, one of the classic senescence regulators, and is decreased in senescent CRC cells. …”
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    Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
  9. 3489
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    Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment
  10. 3490
    “…Experiments using cell cycle analysis, real-time PCR and western blot were performed on genes involved in the senescence phenotype. RESULTS: To shed light on the physiological role of ABCC6, we focused on the phenotype of HepG2 cells that lack ABCC6 activity. …”
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    ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype
  11. 3491
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    Abstract 53: Discrepancies in Senescence and Protein Expression from Cells in Nerve Autografts Compared to Injured Nerve
  12. 3492
    “…Remobilization of leaf nitrogen takes place during senescence, a process known to strongly modify cell and tissue structure. …”
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    Nitrogen deficiency impacts on leaf cell and tissue structure with consequences for senescence associated processes in Brassica napus
  13. 3493
    “…The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. …”
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    Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
  14. 3494
    “…Mcl-1, a Bcl-2 family member, is highly expressed in a variety of human cancers and is believed to enhance tumorigenic potential and chemotherapy resistance through the inhibition of apoptosis and senescence. We previously reported that Mcl-1′s regulation of chemotherapy-induced senescence (CIS) is dependent on its ability to prevent reactive oxygen species (ROS) generation. …”
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    Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence
  15. 3495
    “…Together, these data suggest that GPR1 functions as a negative regulator of pollen germination, pollen tube growth, and gametophyte senescence to fine-tune the fertilization process.…”
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    The Arabidopsis GPR1 Gene Negatively Affects Pollen Germination, Pollen Tube Growth, and Gametophyte Senescence
  16. 3496
    “…YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. …”
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    Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer
  17. 3497
    “…Patients with more severe clinical complications demonstrated a senescent T-cell phenotype whereas patients with lower clinical score had undetectable changes relative to controls. …”
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    Acquired Senescent T-Cell Phenotype Correlates with Clinical Severity in GATA Binding Protein 2-Deficient Patients
  18. 3498
    “…Human kallistatin significantly decreased TNF‐α‐induced cellular senescence in EPCs, as indicated by reduced senescence‐associated β‐galactosidase activity and plasminogen activator inhibitor‐1 expression, and elevated telomerase activity. …”
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    Kallistatin reduces vascular senescence and aging by regulating microRNA‐34a‐SIRT1 pathway
  19. 3499
    “…Leaves of deciduous tree species start senescence in late season, but whether the senescent leaves still retain capacity of carbon assimilation remains a question. …”
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    Photosynthetic capacity of senescent leaves for a subtropical broadleaf deciduous tree species Liquidambar formosana Hance
  20. 3500
    “…Cellular senescence is a complex biological process that leads to irreversible cell-cycle arrest. …”
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    Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases
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