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  1. 3581
    “…Among the many factors that promote cellular senescence, reactive oxygen species (ROS) are a focus of intense research because of their critical role in accelerating cellular senescence and initiating senescence-related diseases that can be fatal. …”
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    Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions
  2. 3582
    “…Here, we have demonstrated that aged ECs are larger than young ECs and that age-dependent increases in EC size control EC proliferation and senescence through CDC42-Yes-associated protein (YAP1) signaling. …”
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    Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1
  3. 3583
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    Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging
  4. 3584
    “…Whether and how D-galactose induces senescence by elevated levels of reactive metabolite MG remain unclear. …”
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    Brain Senescence Caused by Elevated Levels of Reactive Metabolite Methylglyoxal on D-Galactose-Induced Aging Mice
  5. 3585
    “…Moreover, the activated GCS helps to cleave excess glycine and prevents methylglyoxal accumulation, which stimulates senescence in stem cells and during reprogramming. Collectively, our results demonstrate a novel mechanism whereby GCS activation controls stem cell pluripotency by promoting H3K4me3 modification and preventing cellular senescence.…”
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    Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
  6. 3586
    “…Cellular senescence and natural killer (NK) cells play an important role in liver diseases. …”
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    Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis
  7. 3587
    “…The early senescence phenotype was not observed when senescence was induced by darkness. …”
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    Negative Regulation of Age-Related Developmental Leaf Senescence by the IAOx Pathway, PEN1, and PEN3
  8. 3588
    “…Osteoarthritis (OA) is an age-related disorder that is strongly associated with chondrocyte senescence. The causal link between disruptive PTEN/Akt signaling and chondrocyte senescence and the underlying mechanism are unclear. …”
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    Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice
  9. 3589
    “…BACKGROUND: Ginsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. …”
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    Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle
  10. 3590
    “…Senescent fibroblasts that accumulate in tissues secondary to aging and oxidative stress have been shown to promote cancer formation via a senescence‐associated secretory phenotype (SASP). …”
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    Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
  11. 3591
    “…Atrial endothelial senescence was induced by thrombin at clinically relevant concentrations. …”
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    Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns
  12. 3592
    “…Tissue accumulation of p16(INK4a)-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). …”
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    Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development
  13. 3593
    “…As the last stage of plant development, leaf senescence has a great impact on plant’s life cycle. …”
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    Characterization and Mapping of a Novel Premature Leaf Senescence Mutant in Common Tobacco (Nicotiana tabacum L.)
  14. 3594
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    Correction: miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1
  15. 3595
    “…Here we show that reduced autophagy is a central molecular mechanism underlying immune senescence. Autophagy levels are specifically reduced in mature lymphocytes, leading to compromised memory B cell responses in old individuals. …”
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    Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
  16. 3596
    “…Senescence of cardiomyocytes is considered a key factor for the occurrence of doxorubicin (Dox)-associated cardiomyopathy. …”
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    Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation
  17. 3597
    “…In this spontaneous senescence model, NF cells had impaired survival and died by ferroptosis. …”
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    Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging
  18. 3598
    “…Here, we reconstructed the decidual pathway at single-cell level in vitro and demonstrate that stromal cells first mount an acute stress response before emerging as DC or senescent DC (snDC). In the absence of immune cell-mediated clearance of snDC, secondary senescence transforms DC into progesterone-resistant cells that abundantly express extracellular matrix remodelling factors. …”
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    Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window
  19. 3599
    “…RNA-sequencing and bioinformatics analysis indicated senescent phenotype of endometriosis GCs and aggravated endoplasmic reticulum (ER) stress in endometriosis GCs. …”
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    Excessive oxidative stress in cumulus granulosa cells induced cell senescence contributes to endometriosis-associated infertility
  20. 3600
    “…In the present study, we isolated rice senescence-induced receptor-like kinase (OsSRLK), whose transcription was upregulated in senescing rice leaves. …”
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    Rice Senescence-Induced Receptor-Like Kinase (OsSRLK) Is Involved in Phytohormone-Mediated Chlorophyll Degradation
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