“…Cellular senescence is a stress response of human cells that removes potentially harmful cells by initiating cell cycle arrest. …”
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“…Our results showed that the OM(SSA) was highly correlated with this unique index, suggesting that the OM(SSA) was closely linked with senescent algal cells and/or cell lysis. Furthermore, the hygroscopicity parameters κ derived from water-extracted SSA samples implied a reduction in the SSA hygroscopicity with increasing senescent status of phytoplankton. …”
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“…There is a relation between aged dental pulp and the senescence of dental pulp stem cells (DPSCs). Therefore, it is important to investigate the molecular processes underlying the senescence of DPSCs to elucidate the dental pulp aging mechanisms. p-Cresol (PC), a uremic toxin, is strongly related to cellular senescence. …”
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“…A fine-mapping population was developed from an introgression line cross—RSG04008-6 (stay-green) × J2614-11 (moderately senescent). The fine-mapping population with 1894 F(2) was genotyped with eight SSRs and a set of 152 recombinants was identified, advanced to the F(4) generation, field evaluated with three replications over 2 seasons, and genotyped with the GBS approach. …”
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“…OBJECTIVE(S): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. …”
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“…The present study aimed to identify lncRNAs implicated in IVD degeneration via the regulation of cellular senescence. In the present study, nucleus pulposus (NP) cells isolated from moderately degenerated IVD tissues exhibited a senescent phenotype with increased senescence rates, detected by senescence-associated β-galactosidase (SA-β-gal) staining, and reduced growth and migratory abilities. …”
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“…Taken together, current data demonstrated that A. taiwanensis could suppress cellular senescence in HDFs, and might be used for health care.…”
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“…Leaf senescence is the final stage of leaf development. It is accompanied by the remobilization of nutrients from senescent leaves to developing organs. …”
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“…Empagliflozin counteracts the pro‐senescence effect of HG and of hyperosmolar stress on CSC, and improves cardiac function via decreasing cardiac fibrosis and senescence in diabetic mice, possibly through SGLT2 off‐target effects. …”
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“…It activates cellular senescence by increasing SA‐β‐gal activity. BRD4 knockdown by shRNA recapitulates cellular senescence. …”
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“…By contrast, human fibroblasts exhibit limited senescence as their cellular NAD + /NADH balance is comparatively stable during expansion. …”
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“…Additionally, vaccination reduced the proportion of flu-specific FoxP3+ T regulatory cells (Tregs) and decreased levels of TGF-β in aged lungs following infection. Accumulation of senescent cells, another hallmark of aging, can contribute to the inflammatory environment via their senescent associated secretory phenotype (SASP). …”
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“…Endothelial cell (EC) senescence is an important risk factor for CVDs, and recent evidence suggests that FD-induced premature EC senescence increases oxidative stress levels. …”
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“…One of the possible outcomes of anticancer therapy, which has recently gained much interest, is cancer cell senescence. The induction of senescence leads to prolonged inhibition of proliferation and contributes to tumor growth restriction. …”
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“…PDAT1 overexpression prolonged Arabidopsis lifespan in comparison to wild-type plants, whereas knocking out pdat1 accelerated the plant’s senescence. After subjecting the 3-week old seedlings of the studied lines (grown in vitro) to 2-h heat stress (40°C) and then growing them for one more week in standard conditions, the difference in weight between wild-type and PDAT1-overexpressing lines increased in comparison to the difference between plants grown only in optimal conditions. …”
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“…Idiopathic pulmonary fibrosis is an aging-associated disease, satisfactory therapies are not yet available. Accelerated senescence of alveolar epithelial cells plays an important part in Idiopathic pulmonary fibrosis pathogenesis. …”
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“…Cellular senescence is a cell fate implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). …”
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“…In fact, the expression of senescence and senescence-associated secretory phenotype (SASP) markers in 4-5-month-old Ercc1(-/Δ) mice, along with other measurements of senescence, were equivalent and never exceeded the extent of that found in naturally aged mice. …”
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“…CONCLUSION: Roflumilast might attenuate Doxorubicin-induced inflammation and cellular senescence in cardiomyocytes by upregulating SIRT1.…”
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